The Production and Function of Endogenous Interleukin-10 in Intestinal Epithelial Cells and Gut Homeostasis

Nguyen, Huong D.; Aljamaei, Hanan M.; Stadnyk, Andrew W.

doi:10.1016/j.jcmgh.2021.07.005

Cited by 38 publications

(28 citation statements)

References 97 publications

(191 reference statements)

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“…Larvae fed with TG and LG diets had signifcantly lower mRNA expression of tnf-α which is an important proinfammatory factor. Moreover, il-10 is an anti-infammatory cytokine produced mainly by macrophages and plays a role in counteracting and controlling excessive infammatory response [47][48][49]. In the present study, the mRNA expression of il-10 signifcantly increased with the larvae fed with TG and LG diets.…”

Section: Discussionsupporting

confidence: 55%

Tragacanth Gum and Linseed Gum as Adhesives Improved the Survival, Digestive Function, Antioxidant Enzyme Activities, and Immunity in Large Yellow Croaker (Larimichthys crocea) Larvae

Liu

Wang

Zhang

et al. 2023

Aquaculture Research

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A 30-day feeding experiment was designed to investigate the effects of different adhesives on survival, growth performance, digestive enzyme activities, antioxidant capacity, and inflammation response of large yellow croaker (Larimichthys crocea) larvae (initial weight 8.40 ± 0.18 mg). Four iso-nitrogenous (55% crude protein) and iso-lipidic (22% crude lipid) microbound diets (MBD) were formulated to contain 2% sodium alginate (SA), 2% tragacanth gum (TG), 2% linseed gum (LG), and 2% poloxamer (PX), respectively. Results showed that larvae fed with TG and LG diets had significantly higher survival rate than the larvae fed with SA and PX ( P < 0.05 ). Larvae fed with the PX diet had lower final weight and specific growth rate than the other groups ( P < 0.05 ). Larvae fed with TG diet had significant higher activities of lipase in pancreatic segments and trypsin in intestinal segments than the larvae fed with the PX ( P < 0.05 ). Meanwhile, the lipase activities of larvae fed with LG was significantly higher in intestinal segments than those fed with SA and PX diets ( P < 0.05 ). Larvae fed with TG and LG diets had significantly higher activities of AKP in brush border membranes than larvae fed with SA and PX diets ( P < 0.05 ). Moreover, the mRNA expression of pcna and zo-1 increased, respectively, in larvae fed TG and LG diets compared with the other groups ( P < 0.05 ). Larvae fed with LG and TG diets had significantly higher activities of SOD and T-AOC than those fed with PX diet ( P < 0.05 ). The content of GSH increased significantly in larvae fed with SA, TG, and LG diets compared with PX treatment ( P < 0.05 ). The activities of iNOS significantly increased in larvae fed with TG and LG diets compared to other groups ( P < 0.05 ). Meanwhile, the mRNA expression of il-10 significantly increased in TG and LG groups ( P < 0.05 ). In conclusion, results of the study demonstrated that TG and LG can be used as feed binders for microdiets with positive effects on survival, activities of digestive enzymes, antioxidant capacity, and inflammatory response. However, PX inhibited the survival and growth, and further study is needed to determine the suitable usage and dosage.

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Section: Discussionsupporting

confidence: 55%

Tragacanth Gum and Linseed Gum as Adhesives Improved the Survival, Digestive Function, Antioxidant Enzyme Activities, and Immunity in Large Yellow Croaker (Larimichthys crocea) Larvae

Liu

Wang

Zhang

et al. 2023

Aquaculture Research

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“…IL10 family cytokines share similar structures, common receptors, and downstream signaling [ 86 ]. Studies have shown that IL10 and IL22 play an important role in maintaining the health of the epithelial barrier of the intestine, and they are often deficient in patients with IBD [ 87 , 88 ]. There are significant differences in the expression patterns of IL10 and IL22 between patients with IBD and healthy individuals [ 89 , 90 ].…”

Section: Scfas Promote Intestinal Barrier Stability By Regulating Cyt...mentioning

confidence: 99%

“…This may be due to the relatively low bioavailability of IL10 to the intestinal mucosa [ 120 ]. To overcome this difficulty, researchers attempted to engineer IL10-producing probiotics to deliver IL10; however, this too has been unsuccessful [ 88 , 121 ]. Moreover, IL10 may promote the development of cancer to some extent.…”

Section: Immunonutrition Therapy Is a Viable Option For Ibdmentioning

confidence: 99%

Regulatory role of short-chain fatty acids in inflammatory bowel disease

et al. 2022

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Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders of the gastrointestinal tract. Accumulating evidence shows that the development of IBD is always accompanied by the dysbiosis of the gut microbiota (GM), causing a decrease in prebiotic levels and an increase in harmful metabolite levels. This leads to persistent immune response and inflammation in the intestine, greatly impairing the physiological function of the gastrointestinal tract. Short-chain fatty acids (SCFAs) are produced by probiotic gut bacteria from a fiber-rich diet that cannot be digested directly. SCFAs with significant anti-inflammatory functions regulate immune function and prevent an excessive immune response, thereby delaying the clinical progression of IBD. In this review, we summarize the generation of SCFAs and their potential therapeutic effects on IBD. Furthermore, we suggest that SCFAs may modulate innate immune recognition and cytokine production to intervene in the progression of IBD. Additional randomized controlled trials and prospective cohort studies should also investigate the clinical impact of SCFA.

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“…TAMs play a pivotal role in impairing the functions of antitumor, cytotoxic CD8 + T cells, and natural killer cells by releasing the anti-inflammatory cytokine IL-10 [ 1 , 4 ]. Multiple distinct signaling pathways were found to be responsible for the transcriptional regulation of IL-10 in immune and non-immune cells [ 35 , 36 ]. The IL-10 promoter was activated by CREB through the ERK1/2 signaling pathway in native THP-1 cells [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Downregulation of IL-8 and IL-10 by the Activation of Ca2+-Activated K+ Channel KCa3.1 in THP-1-Derived M2 Macrophages

Ohya

Matsui

Kajikuri

et al. 2022

IJMS

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THP-1-differentiated macrophages are useful for investigating the physiological significance of tumor-associated macrophages (TAMs). In the tumor microenvironment (TME), TAMs with the M2-like phenotype play a critical role in promoting cancer progression and metastasis by inhibiting the immune surveillance system. We examined the involvement of Ca2+-activated K+ channel KCa3.1 in TAMs in expressing pro-tumorigenic cytokines and angiogenic growth factors. In THP-1-derived M2 macrophages, the expression levels of IL-8 and IL-10 were significantly decreased by treatment with the selective KCa3.1 activator, SKA-121, without changes in those of VEGF and TGF-β1. Furthermore, under in vitro experimental conditions that mimic extracellular K+ levels in the TME, IL-8 and IL-10 levels were both significantly elevated, and these increases were reversed by combined treatment with SKA-121. Among several signaling pathways potentially involved in the transcriptional regulation of IL-8 and IL-10, respective treatments with ERK and JNK inhibitors significantly repressed their transcriptions, and treatment with SKA-121 significantly reduced the phosphorylated ERK, JNK, c-Jun, and CREB levels. These results strongly suggest that the KCa3.1 activator may suppress IL-10-induced tumor immune surveillance escape and IL-8-induced tumorigenicity and metastasis by inhibiting their production from TAMs through ERK-CREB and JNK-c-Jun cascades.

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The Production and Function of Endogenous Interleukin-10 in Intestinal Epithelial Cells and Gut Homeostasis

Cited by 38 publications

References 97 publications

Tragacanth Gum and Linseed Gum as Adhesives Improved the Survival, Digestive Function, Antioxidant Enzyme Activities, and Immunity in Large Yellow Croaker (Larimichthys crocea) Larvae

Tragacanth Gum and Linseed Gum as Adhesives Improved the Survival, Digestive Function, Antioxidant Enzyme Activities, and Immunity in Large Yellow Croaker (Larimichthys crocea) Larvae

Regulatory role of short-chain fatty acids in inflammatory bowel disease

Downregulation of IL-8 and IL-10 by the Activation of Ca2+-Activated K+ Channel KCa3.1 in THP-1-Derived M2 Macrophages

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