The Production of Isoantibodies in the Dog by Immunization With Homologous Tissue

Puza, A; Rubinstein, Pablo; Kasakura, S; Vlahović, Š.; Jw, Ferrebee

doi:10.1097/00007890-196411000-00005

Cited by 11 publications

(3 citation statements)

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“…Anti-sera plus complement and mixed leukocyte reactions using dog leukocytes were routinely performed to select appropriate matched or mismatched littermates for HCT studies. [14][15][16][17][18] Using these typing methods, an HCT study comprised of 16 serotype-matched donor and recipient pairs showed that all recipients engrafted after receiving 1500 to 1580 Rads of total body irradiation. Six dogs died of GVHD, three died of pneumonia, and seven survived long-term without GVHD.…”

Section: Dla Typingmentioning

confidence: 99%

“…Initially, MHC typing of littermate pairs for HCT relied upon a battery of anti‐leukocyte sera, obtained by cross‐immunizing littermate pairs with buffy coat blood cells. Anti‐sera plus complement and mixed leukocyte reactions using dog leukocytes were routinely performed to select appropriate matched or mismatched littermates for HCT studies 14‐18 . Using these typing methods, an HCT study comprised of 16 serotype‐matched donor and recipient pairs showed that all recipients engrafted after receiving 1500 to 1580 Rads of total body irradiation.…”

Section: Introductionmentioning

confidence: 99%

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Developments and translational relevance for the canine haematopoietic cell transplantation preclinical model

Graves

Storb

2020

Vet Comparative Oncology

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The development of safe and reliable haematopoietic cell transplantation (HCT) protocols to treat human patients with malignant and non-malignant blood disorders was highly influenced by preclinical studies obtained in random-bred canines. The surmounted barriers included recognizing the crucial importance of histocompatibility matching, establishing long-term donor haematopoietic cell engraftment, preventing graft-vs-host disease and advancing effective conditioning and post-grafting immunosuppression protocols, all of which were evaluated in canines. Recent studies have applied the tolerance inducing potential of HCT to solid organ and vascularized composite tissue transplantation. Several advances in HCT and tolerance induction that were first developed in the canine preclinical model and subsequently applied to human patients are now being recruited into veterinary practice for the treatment of malignant and non-malignant disorders in companion dogs. Here, we review recent HCT advancements attained in the canine model during the past 15 years.

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Section: Dla Typingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Developments and translational relevance for the canine haematopoietic cell transplantation preclinical model

Graves

Storb

2020

Vet Comparative Oncology

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“…In further studies of this question, Kasakura, Thomas, and Ferrebee (29), Puza et al (30), Rubinstein and Ferrebee (31), Cleton, van Es, Ponsen, and van Rood (32), Cohen and Kozari (33), and Epstein, Storb, Ragde, and Thomas (34) observed that immunization of dogs, and particularly of littermatcs (34), with buffy coat cells resulted in the appearance of leukocyte group-specific isoantibodies in the recipients. In an extension of the elegant studies of Epstein et al (34), Rubinstein and associates (35), and Mollen et al (36) produced a battery of typing sera capable of detecting 10 different leukocyte antigen specificities (or sets of specificities) in the Cooperstown colony of beagles.…”

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confidence: 96%

Histocompatibility Studies in a Closely Bred Colony of Dogs

Rapaport

Watanabe

Cannon

et al. 1972

The Journal of Experimental Medicine

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17 Cooperstown beagles of known DL-A genotypes were exposed to supralethal total body irradiation and received a bone marrow allograft from a DL-A-identical donor; 11 littermate and 6 nonlittermate donor-recipient pairs were studied. The recipients are surviving uneventfully for 315, 364, 424, 440, 531, 531, 584, 605, 625, 635, and 649 days in the littermate group and for 211, 279, 280, 368, 479, and 480 days in the nonlittermate group. The radiation chimeras underwent bilateral nephrectomy and received a kidney allograft obtained from their respective marrow donor within 43–120 days after bone marrow transplantation. The renal allografts are surviving for 191, 200, 221, 234, 313, 349, 361, 377, 378, 405, 441, 444, 482, 557, 580, 581, and 586 days, respectively. 12 of 13 skin allografts obtained from the marrow donor are at present surviving in the recipients for 107, 110, 110, 110, 116, 122, 128, 143, 143, 162, 178, and 199 days, respectively; one graft was rejected at 84 days. In contrast, the radiation chimeras rejected 25 skin allografts obtained from DL-A-incompatible donors within 10.5–21 days (MST = 15.2 days). Skin transplants obtained from DL-A-identical siblings of the bone marrow donors were rejected within 20–36 days (MST = 25.8 days) in recipients of bone marrow cells obtained from littermate donors. Recipients of nonlittermate bone marrow transplants accorded such allografts a prolonged survival time of 27–76 days (MST = 56.2 days). Prospective selection of genotypically DL-A-identical donor-recipient pairs results in the regularly reproducible long-term survival of bone marrow allografts. The radiation chimeras produced in this manner have developed a donor-specific state of unresponsiveness to kidney and skin allografts. The results are consistent with the existence in the canine species of at least three closely linked genetic systems relevant to transplantation, including DL-A, MLC, and a possible bone marrow transplantation locus.

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