The prognostic and clinical value of p53 upregulated modulator of apoptosis expression in solid tumors: a meta-analysis and TCGA data review

Gao, Weifeng; Yuan, Zhen; Zhao, Xuanzhu; Wang, Shuyuan; Lai, Sizhen; Zhan, Yixiang; Liu, Zhaoce; Liu, Lina; Ran, Xin; Yin, Xin; Zhou, Xingyu; Liu, Xinyu; Zhang, Qinghuai; Li, Guoxun; Wang, Wenhong; Zhang, Chunze

doi:10.1080/14737159.2022.2125802

Expert Review of Molecular Diagnostics

2022

DOI: 10.1080/14737159.2022.2125802

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The prognostic and clinical value of p53 upregulated modulator of apoptosis expression in solid tumors: a meta-analysis and TCGA data review

Weifeng Gao

Zhen Yuan

Xuanzhu Zhao

et al.

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2024

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Identification of Cuproptosis-Associated Prognostic Gene Expression Signatures from 20 Tumor Types

Ooko,

Ali,

Efferth

2024

Biology

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We investigated the mRNA expression of 124 cuproptosis-associated genes in 7489 biopsies from 20 different tumor types of The Cancer Genome Atlas (TCGA). The KM plotter algorithm has been used to calculate Kaplan–Meier statistics and false discovery rate (FDR) corrections. Interaction networks have been generated using Ingenuity Pathway Analysis (IPA). High mRNA expression of 63 out of 124 genes significantly correlated with shorter survival times of cancer patients across all 20 tumor types. IPA analyses revealed that their gene products were interconnected in canonical pathways (e.g., cancer, cell death, cell cycle, cell signaling). Four tumor entities showed a higher accumulation of genes than the other cancer types, i.e., renal clear cell carcinoma (n = 21), renal papillary carcinoma (n = 13), kidney hepatocellular carcinoma (n = 13), and lung adenocarcinoma (n = 9). These gene clusters may serve as prognostic signatures for patient survival. These signatures were also of prognostic value for tumors with high mutational rates and neoantigen loads. Cuproptosis is of prognostic significance for the survival of cancer patients. The identification of specific gene signatures deserves further exploration for their clinical utility in routine diagnostics.

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Identification of Cuproptosis-Associated Prognostic Gene Expression Signatures from 20 Tumor Types

Ooko,

Ali,

Efferth

2024

Biology

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show abstract

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The prognostic and clinical value of p53 upregulated modulator of apoptosis expression in solid tumors: a meta-analysis and TCGA data review

Cited by 1 publication

References 31 publications

Identification of Cuproptosis-Associated Prognostic Gene Expression Signatures from 20 Tumor Types

Identification of Cuproptosis-Associated Prognostic Gene Expression Signatures from 20 Tumor Types

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