The Prognostic and Predictive Value of Expression of P-AKT in Patients with FIGO IIB Locally Advanced Cervical Cancer under Chemotherapy.

Koçak, Mihriban; Barışık, Nagehan Özdemir; Mayadağlı, Alpaslan; Gemici, Cengiz; Eren, Makbule; Naki, Murat; Ozseker, Naciye; Aksu, Atinc

doi:10.4999/uhod.11070

Cited by 1 publication

(3 citation statements)

References 23 publications

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“…Other studies have analyzed pre-treatment tissues of patients with locally advanced cervical cancer and found that 86% (Kocak et al 2013), and 74% (Kim et al 2006), classify as "positive" for Akt. These studies used a different method to analyze the expression of Akt, which classified according to the intensity and quality of staining from Akt inside the cancer cell (Kim et al 2006;Suzuki et al 2010).…”

Section: Discussionmentioning

confidence: 97%

“…Some studies report a positive correlation between Akt expression and prognosis/response, while others have found a negative correlation. In the majority of studies, the expression of Akt is observed qualitatively using immunohistochemistry method (Kim et al 2006;Faried et al 2006;Zhang & Zhang 2008;Kocak et al 2013). The aim of the present research was to detect and evaluate any relationship between the expression of Akt in cervical cancer tissues measured by the IRS (Immno Reactive Score) method and p53 index with cervical cancer chemoradiotherapy response.…”

Section: Introductionmentioning

confidence: 98%

“…Cancer cells with an inactivated, or mutant p53 protein cannot function properly and so replication of abnormal DNA is not prevented. In fact, inactivation of wildtype p53 gene represents the most common genetic mutation implicated in human carcinogenesis (Fei & El Deiry 2003;Brenna et al 2004), and some researchers maintain that its over-expression, as detected by immunohistochemistry, indicates a worse prognosis in some malignancies (Wootipoom et al 2004;Kocak et al 2013;Min et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Correlation Between Akt and p53 Protein Expression and Chemoradiotherapy Response in Cervical Cancer Patients

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HAYATI Journal of Biosciences

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Akt is a protein that is associated with cell proliferation and is expressed at high levels in cancer cells. Some research indicates it may play a role in increasing the resistance of cancer cells to chemotherapy treatment. P53 is a tumor suppressor protein that influences the cell cycle and apoptosis. The purpose of this study was to examine the relationship between the expression of Akt and p53 in cancerous tissue before chemoradiation treatment, and the clinical response to treatment of cervical cancer patients. Twenty microscopic tissue samples were taken from cervical cancer biopsies obtained from patients before cancer treatment. The tissue samples were stained with p53 and Akt antibodies via immunohistochemistry technique, to measure expression of both proteins. After completion of chemoradiotherapy, patients' clinical response to treatment was determined using the pelvic control method. Our results revealed no correlation between expression of Akt and p53 index (P = 0.74) as well as between p53 Index and chemoradiotherapy clinical response (P=0.29). There was significant correlation between expression of Akt and cervical cancer chemoradiotherapy response (P = 0.03). There was no correlation found between p53 index and chemoradiotherapy clinical response (P = 0.29). High expression of Akt may related with high cell proliferation and resistance to chemoradiotherapy.

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