The prognostic and predictive values of differential expression of exosomal receptor tyrosine kinases and associated with the PI3K/AKT/mTOR signaling in breast cancer patients undergoing neoadjuvant chemotherapy

Eskiler, Gamze Güney; Kazan, Nur; Haciefendi, Ayten; Özkan, Asuman Deveci; Özdemir, Kayhan; Özen, Miraç; Koçer, Havva Belma; Yılmaz, Fahri; Kaleli, Süleyman; Şahin, Elvan; Bilir, Cemil

doi:10.1007/s12094-022-02959-9

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…The downregulation of TSG101 decreases the secretion of WNT5B-containing exosomes from colorectal cancer cells [ 61 ]. Exosomal levels of receptor tyrosine kinases, such as platelet-derived growth factor receptor B, are decreased by chemotherapy in breast cancer patients [ 62 ], and the exosomes released from normal cells and cancer cells are quantitatively and qualitatively different [ 62 ]. These reports suggest that exosomal proteins play important roles in the biogenesis of exosomes, cancer initiation and progression, and the response to chemotherapy.…”

Section: Contents Of Exosomes: Exosomal Proteinsmentioning

confidence: 99%

Exosomes: Diagnostic and Therapeutic Implications in Cancer

Shim

Jeoung

2023

Pharmaceutics

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Exosomes are a subset of extracellular vesicles produced by all cells, and they are present in various body fluids. Exosomes play crucial roles in tumor initiation/progression, immune suppression, immune surveillance, metabolic reprogramming, angiogenesis, and the polarization of macrophages. In this work, we summarize the mechanisms of exosome biogenesis and secretion. Since exosomes may be increased in the cancer cells and body fluids of cancer patients, exosomes and exosomal contents can be used as cancer diagnostic and prognostic markers. Exosomes contain proteins, lipids, and nucleic acids. These exosomal contents can be transferred into recipient cells. Therefore, this work details the roles of exosomes and exosomal contents in intercellular communications. Since exosomes mediate cellular interactions, exosomes can be targeted for developing anticancer therapy. This review summarizes current studies on the effects of exosomal inhibitors on cancer initiation and progression. Since exosomal contents can be transferred, exosomes can be modified to deliver molecular cargo such as anticancer drugs, small interfering RNAs (siRNAs), and micro RNAs (miRNAs). Thus, we also summarize recent advances in developing exosomes as drug delivery platforms. Exosomes display low toxicity, biodegradability, and efficient tissue targeting, which make them reliable delivery vehicles. We discuss the applications and challenges of exosomes as delivery vehicles in tumors, along with the clinical values of exosomes. In this review, we aim to highlight the biogenesis, functions, and diagnostic and therapeutic implications of exosomes in cancer.

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Section: Contents Of Exosomes: Exosomal Proteinsmentioning

confidence: 99%

Exosomes: Diagnostic and Therapeutic Implications in Cancer

Shim

Jeoung

2023

Pharmaceutics

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“…Studies have shown that tumor-derived exosomes (TDEs) can act on target cells to promote cancer angiogenesis ( 35 , 36 ), facilitate the transformation of cancer stromal cells to a pro-cancer phenotype, and change the cancer niche ( 2 , 37 ) to urge cancer initiation and progression. In clinical data statistics, the molecular content of exosomes has an excellent prognostic or predictive value in cancer progression and treatment response of cancer patients ( 38 ). Exosomes also include specific biomarkers of their cellular origin.…”

Section: Introductionmentioning

confidence: 99%

Exosomes and cancer immunotherapy: A review of recent cancer research

Cao

Xu²,

Shen

et al. 2023

Front. Oncol.

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As phospholipid extracellular vesicles (EVs) secreted by various cells, exosomes contain non-coding RNA (ncRNA), mRNA, DNA fragments, lipids, and proteins, which are essential for intercellular communication. Several types of cells can secrete exosomes that contribute to cancer initiation and progression. Cancer cells and the immune microenvironment interact and restrict each other. Tumor-derived exosomes (TDEs) have become essential players in this balance because they carry information from the original cancer cells and express complexes of MHC class I/II epitopes and costimulatory molecules. In the present study, we aimed to identify potential targets for exosome therapy by examining the specific expression and mechanism of exosomes derived from cancer cells. We introduced TDEs and explored their role in different tumor immune microenvironment (TIME), with a particular emphasis on gastrointestinal cancers, before briefly describing the therapeutic strategies of exosomes in cancer immune-related therapy.

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The prognostic and predictive values of differential expression of exosomal receptor tyrosine kinases and associated with the PI3K/AKT/mTOR signaling in breast cancer patients undergoing neoadjuvant chemotherapy

Cited by 2 publications

References 31 publications

Exosomes: Diagnostic and Therapeutic Implications in Cancer

Exosomes: Diagnostic and Therapeutic Implications in Cancer

Exosomes and cancer immunotherapy: A review of recent cancer research

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