The prognostic implications and tumor-suppressive functions of CYR61 in estrogen receptor-positive breast cancer
Cheng Zhang,
Zhihua Li,
Kaiheng Hu
et al.
Abstract:Due to the therapeutic resistance of endocrine therapy and the limited efficacy of immune checkpoint inhibitors in estrogen receptor (ER)-positive breast cancer (BRCA), there is an urgent need to develop novel prognostic markers and understand the regulation of the tumor immune microenvironment (TIME). As a matricellular protein, CYR61 has been shown to either promote or suppress cancer progression depending on cancer types. However, how CYR61 functions in ER-positive BRCA remains elusive. In this study, we co… Show more
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