The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review

Casadevall, David; Kilian, Anaïs Yacine; Bellmunt, Joaquim

doi:10.1016/j.ctrv.2017.10.004

Cited by 24 publications

(21 citation statements)

References 113 publications

(285 reference statements)

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“…As an example, promoter methylation of several targets have been investigated in a liquid biopsy setting for proper monitoring of the disease, including in urine [34][35][36] (for further reading refer to [37]). Many studies have found several biomarkers informative for disease aggressiveness and patient outcome, including microRNAs, gene promoter methylation and specific histone modifications and chromatin alterations [38,39]. These epigenetic players were shown (in vitro and in vivo) to interact and regulate more or less extensively several hallmarks of cancer, including epithelial-to-mesenchymal transition (EMT), proliferation, survival, stemness, resistance to treatments, among others [40,41].…”

Section: Role Of Immunoepigenetics?mentioning

confidence: 99%

Targeting the Immune system and Epigenetic Landscape of Urological Tumors

Lobo

Jerónimo

Henrique

2020

IJMS

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In the last years, we have witnessed remarkable advances in targeted therapies for cancer patients. There is a growing effort to either replace or reduce the dose of unspecific, systemic (chemo)therapies, given the associated short- and long-term side effects, by introducing more specific targeted therapies as single or combination agents. Due to the well-known implications of the immune system and epigenetic landscape in modulating cancer development, both have been explored as potential targets in several malignancies, including those affecting the genitourinary tract. As the immune system function is also epigenetically regulated, there is rationale for combining both strategies. However, this is still rather underexplored, namely in urological tumors. We aim to briefly review the use of immune therapies in prostate, kidney, bladder, and testicular cancer, and further describe studies providing supporting evidence on their combination with epigenetic-based therapies.

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Section: Role Of Immunoepigenetics?mentioning

confidence: 99%

Targeting the Immune system and Epigenetic Landscape of Urological Tumors

Lobo

Jerónimo

Henrique

2020

IJMS

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“…These molecules usually play multiple roles in the malignant behavior of most cancers, including bladder cancer. For example, MMP-9 plays an important role in apoptosis and cell migration, while Wnt signaling plays an important role in cell proliferation, cell cycle regulation, apoptosis, and migration in bladder cancer [ 93 , 94 ]. We propose that identification of detailed molecular mechanisms of anticancer cell effects by GTPs is essential for targeting the key signaling molecules.…”

Section: Bladder Cancer and Green Teamentioning

confidence: 99%

Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer

et al. 2018

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Green tea and green tea polyphenols (GTPs) are reported to inhibit carcinogenesis and malignant behavior in several diseases. Various in vivo and in vitro studies have shown that GTPs suppress the incidence and development of bladder cancer. However, at present, opinions concerning the anticancer effects and preventive role of green tea are conflicting. In addition, the detailed molecular mechanisms underlying the anticancer effects of green tea in bladder cancer remain unclear, as these effects are regulated by several cancer-related factors. A detailed understanding of the pathological roles and regulatory mechanisms at the molecular level is necessary for advancing treatment strategies based on green tea consumption for patients with bladder cancer. In this review, we discuss the anticancer effects of GTPs on the basis of data presented in in vitro studies in bladder cancer cell lines and in vivo studies using animal models, as well as new treatment strategies for patients with bladder cancer, based on green tea consumption. Finally, on the basis of the accumulated data and the main findings, we discuss the potential usefulness of green tea as an antibladder cancer agent and the future direction of green tea-based treatment strategies for these patients.

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“…Histologically distinct bladder cancer subtypes and rare exstrophy of the bladder are shown (upper section). The known genes with altered DNA methylation levels in bladder cancer are classified (lower section, adapted from Casadevall et al [17]). (A higher resolution / colour version of this figure is available in the electronic copy of the article).…”

Section: Introductionmentioning

confidence: 99%

DNA Methylation and Bladder Cancer: Where Genotype does not Predict Phenotype

Sharma

Reutter

Ellinger

2020

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Nearly three decades ago, the association between Bladder cancer (BC) and DNA methylation has initially been reported. Indeed, in the recent years, the mechanism connecting these two has gained deeper insights. Still, the mediocre performance of DNA methylation markers in the clinics raises the major concern. Strikingly, whether it is the inter-individual methylation variations or the paucity of knowledge about methylation fingerprints lying within histologically distinct subtypes of BC requires critical discussion. In the future, besides identifying the initial causative factors, it will be important to illustrate the cascade of events that determines the fraction of the genome to convey altered methylation patterns specific towards each cancer type.

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The prognostic role of epigenetic dysregulation in bladder cancer: A systematic review

Cited by 24 publications

References 113 publications

Targeting the Immune system and Epigenetic Landscape of Urological Tumors

Targeting the Immune system and Epigenetic Landscape of Urological Tumors

Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer

DNA Methylation and Bladder Cancer: Where Genotype does not Predict Phenotype

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