The prognostic signature based on glycolysis-immune related genes for acute myeloid leukemia patients

Hou, Hui; Wu, Yu; Guo, Junmei; Zhang, Wei; Wang, Runmei; Yang, Hao; Wang, Zhenfei

doi:10.1016/j.imbio.2023.152355

Cited by 1 publication

(2 citation statements)

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“…Later functional studies with purified proteins confirmed that TMT1B’s methyltransferase activity is SAM-dependent ( 13 , 16 , 17 ), while microscopy studies with cultured cells refined its subcellular localisation to the perinuclear face of the ER ( 13 , 17 , 18 ), and the surface of lipid droplets (LD) ( 18 , 19 ), rather than the Golgi body ( 18 , 20 ). Differential expression of TMT1B has been found to occur within several cancer types ( 4 ), including gliomas ( 21 – 25 ), non-small cell lung cancer ( 16 , 23 , 26 – 29 ), and acute myeloid leukemia ( 30 , 31 ). TMT1B has been proposed as a biomarker for many of these cancers since its increased transcription and protein abundance is frequently correlated with an advanced TNM (Tumour, Node, Metastasis) stage of tumour development and poor patient overall survival ( 21 – 27 , 29 , 31 – 36 ), risk of recurrence ( 35 ) and drug resistance ( 16 , 37 ).…”

Section: Introduction: Methyltransferases and The Mettl Familymentioning

confidence: 99%

“…Differential expression of TMT1B has been found to occur within several cancer types ( 4 ), including gliomas ( 21 – 25 ), non-small cell lung cancer ( 16 , 23 , 26 – 29 ), and acute myeloid leukemia ( 30 , 31 ). TMT1B has been proposed as a biomarker for many of these cancers since its increased transcription and protein abundance is frequently correlated with an advanced TNM (Tumour, Node, Metastasis) stage of tumour development and poor patient overall survival ( 21 – 27 , 29 , 31 – 36 ), risk of recurrence ( 35 ) and drug resistance ( 16 , 37 ). Despite these characterizations, the exact substrate of TMT1B, and its role in the various cancers where it is highly expressed, have not yet been defined.…”

Section: Introduction: Methyltransferases and The Mettl Familymentioning

confidence: 99%

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Defining the elusive oncogenic role of the methyltransferase TMT1B

Denford

Wilhelm

2023

Front. Oncol.

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Methyltransferases are enzymes fundamental to a wide range of normal biological activities that can become dysregulated during oncogenesis. For instance, the recent description of the methyltransferase-like (METTL) family of enzymes, has demonstrated the importance of the N6-adenosine-methyltransferase (m6A) modification in transcripts in the context of malignant transformation. Because of their importance, numerous METTL family members have been biochemically characterized to identify their cellular substrates, however some members such as METTL7B, recently renamed TMT1B and which is the subject of this review, remain enigmatic. First identified in the stacked Golgi, TMT1B is also localized to the endoplasmic reticulum as well as lipid droplets and has been reported as being upregulated in a wide range of cancer types including lung cancer, gliomas, and leukemia. Interestingly, despite evidence that TMT1B might act on protein substrates, it has also been shown to act on small molecule alkyl thiol substrates such as hydrogen sulfide, and its loss has been found to affect cellular proliferation and migration. Here we review the current evidence for TMT1B’s activity, localization, and potential biological role in the context of both normal and cancerous cell types.

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