The prognostic significance of margin width for extremity and trunk sarcoma

Abstract

Margins > or =10 mm independently predicted longer LRFI and are optimal for extremity STS resection. Adjuvant radiotherapy should be considered for all STS resected with margins <10 mm, and margin width should be considered when reporting and interpreting LR outcomes for these patients.

Adult Soft Tissue Sarcoma Local Recurrence After Adjuvant Treatment Without Resection of Core Needle Biopsy Tract

“…This was equal to or lower compared with previous studies (22%-49%) [4,22,25,36,37,43,51,55,56,58,65]. Margin status did not have a statistically negative effect on the rate of metastases; however, given the small number of R1 margins, a conclusion cannot be drawn from this either.…”

“…There were five local recurrences (9%) among our patients, which was lower than numerous studies that evaluated local recurrences in patients with soft tissue sarcomas (13%-39%) [4,22,25,36,37,43,51,55,56,58,65]. Some of these studies included all tumor grades, superficial and deep tumors as well as trunk wall and retroperitoneal tumors.…”

“…Historically reported rates of local recurrence of soft tissue sarcomas range from 13% to 29% and metastases from 22% to 49% [4,22,25,36,37,43,51,55,56,58,65]. The addition of radiation to the wide resection of sarcomas improves local recurrence rates from 19% to 30% in certain studies, even in patients with microscopically positive margins [3,12,16,27,30,52,53,60,62].…”

Extremity Soft Tissue Sarcoma Resections: How Wide Do You Need to Be?

“…Positive resection margins reportedly increase the risk of local recurrence [4,19,[22][23][24][25][26]. Controversy exists as to the amount of the surrounding normal tissue that constitutes an adequate negative margin [2,3,10,11,[13][14][15][16][17] to prevent local recurrence. The issue of what constitutes an adequate margin is complicated by the question of the relative importance of qualitative versus quantitative margin.…”

Clinicopathological Evaluation of Leiomyosarcomas: A Study of Ten Cases

“…Surgical margin of at least 10 mm is required to reduce the risk of local tumour recurrence. 7 Long term follow up is must for all the patients presenting with leiomyosarcomas as late recurrences have also been noted in a number of cases. Local control of leiomyosarcomas is usually achieved with wide surgical resection.…”