The prognostic value and pathobiological significance of Glasgow microenvironment score in gastric cancer

Zhou, Zhihua; Ji, Chao; Zhu, Jiang; Xiao, Hualiang; Zhao, Haibin; Cui, You‐Hong; Bian, Xiu‐Wu

doi:10.1007/s00432-017-2346-1

Cited by 22 publications

(32 citation statements)

References 38 publications

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“…GMS is a combination of TSP and KM grade and a few studies have reported a prognostic role of GMS in some subsets of cancer, including colorectal and gastric cancers. In this study, as TSP was not significantly correlated with survival in patient with high KM grade, the high KM grade, irrespective of TSP, can be classified into GMS 0, as in the previous studies . Lower GMS correlated with favorable clinicopathologic factors and clinical outcome.…”

Section: Discussionsupporting

confidence: 51%

“…High TSP significantly correlated with low KM grade and there were only 7 cases (3.6%) showing high TSP with high KM grade. This finding suggests that tumor stroma may act as a suppressant of host inflammatory reaction to tumor cells , and the inflammatory responses may hinder the formation of tumor stroma . Some studies illustrated that cancer‐associated fibroblasts, which is one of the components of tumor stroma, could interact with host immune cells inducing immune tolerance .…”

Section: Discussionmentioning

confidence: 99%

“…Lower GMS was an independent good prognostic factor in gastric cancer and may improve prognosis evaluation in gastric cancer patients. In addition, GMS represents characteristics of tumor microenvironments . Lower GMS is indicative of an inflammatory environment, while higher GMS represents a desmoplastic microenvironment .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, GMS represents characteristics of tumor microenvironments . Lower GMS is indicative of an inflammatory environment, while higher GMS represents a desmoplastic microenvironment . According to the GMS, the patients may have different biologic features, prognosis, and potential treatment options .…”

Section: Discussionmentioning

confidence: 99%

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Tumor microenvironmental factors have prognostic significances in advanced gastric cancer

Ahn

Chae

Kim

et al. 2018

APMIS

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Ahn B, Chae Y-S, Kim CH, Lee Y, Lee JH, Kim JY. Tumor microenvironmental factors have prognostic significances in advanced gastric cancer. APMIS 2018; 126: 814-821.Tumor microenvironment is important in the progression and survival of cancer cells. We evaluated the prognostic significance of tumor stroma percentage (TSP), Klintrup-M€ akinen (KM) grade, which reflects the density of inflammatory cells of the tumor, and Glasgow microenvironment score (GMS), a combination of TSP and KM grade, in advanced gastric cancers. A total of 196 pT3 and pT4 gastric cancers were histologically evaluated using TSP, KM grade, and GMS. These were correlated with other clinicopathologic factors including patients' survival. High TSP (78 cases), low KM grade (124 cases), and higher GMS (score 0, 72 cases; 1, 53 cases; and 2, 71 cases) were correlated with poor differentiation, diffuse type, presence of lymphovascular invasion, perineural invasion, and lymph node metastasis. High TSP was significantly correlated with low KM grade (p < 0.001). High TSP (HR, 3.079, 95% CI, 1.612-5.883, p = 0.001), low KM grade (3.201, 1.774-5.776, p < 0.001), and higher GMS (12.274,, p < 0.001) were independent poor prognostic factors. TSP, KM grade, and GMS are significantly associated with clinicopathologic behavior and patients' survival. Assessing these factors is a feasible and cost-effective way to identify tumor microenvironment with different biological features and prognosis of gastric cancer patients.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Tumor microenvironmental factors have prognostic significances in advanced gastric cancer

Ahn

Chae

Kim

et al. 2018

APMIS

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“…A number of studies have also found similar results for the prognostic role CAR or GPS in various types of cancers. [7][8][9][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] This highlighted the general prognostic role of these two inflammation-based scores in malignancies.…”

Section: Discussionmentioning

confidence: 99%

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

Chen

Liu

Feng

et al. 2020

CMAR

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The prognostic significance of inflammation-based biomarkers for neuroblastoma (NB) has not been investigated before. The aim of this study was to evaluate the prognostic value of pre-treatment inflammation biomarkers in children patients with NB. Patients and Methods: Patients diagnosed with NB from 2008 to 2016 in our institution were enrolled in this study. The clinical data and survival outcomes were retrospectively reviewed. Inflammation biomarkers or scores including C-reactive protein (CRP), albumin (ALB), Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), high-sensitivity modified Glasgow Prognostic Score (Hs-mGPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and system inflammation index (SII) were tested in this study. Univariate and multivariate survival analyses were performed to assess the prognostic value of these inflammation indicators for overall survival (OS) of children with NB. Kaplan-Meier survival curves were also conducted. Results: A total of 70 children diagnosed with neuroblastoma were enrolled in this study. NLR, PLR, LMR and SII were found to be not predictive of OS for NB patients. However, CRP, ALB, GPS and CAR were significantly associated with OS of NB patients. Multivariate analysis adjusting for age, sex, histology, tumor size, tumor stage and metastasis revealed that ALB, CAR, GPS and Hs-mGPS were significantly associated with OS of NB patients. Receiver operating characteristic (ROC) curves and Akaike Information Criterion (AIC) analyses revealed that Hs-mGPS is superior to other inflammation biomarkers in predicting OS of NB patients. Subgroup survival analysis for immature NB patients revealed similar results. Conclusion: Hs-mGPS is an effective prognostic factor for OS of patients with NB and is promising to be used as a factor for risk stratification and an indicator for more aggressive therapy.

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A new practical method of estimating tumoral microenvironment parameters of possible prognostic significance in patients with invasive breast carcinoma: Combined microenvironment score

Öztürk

Okçu

Öztürk

et al. 2023

Annals of Diagnostic Pathology

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The prognostic value and pathobiological significance of Glasgow microenvironment score in gastric cancer

Abstract: GMS can serve as a useful prognostic factor for gastric cancer, and according to GMS, the tumor microenvironment in this cancer type may be partially classified as inflammatory or desmoplastic microenvironment that possesses different pathobiological features.

Cited by 22 publications

References 38 publications

Tumor microenvironmental factors have prognostic significances in advanced gastric cancer

Tumor microenvironmental factors have prognostic significances in advanced gastric cancer

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

A new practical method of estimating tumoral microenvironment parameters of possible prognostic significance in patients with invasive breast carcinoma: Combined microenvironment score

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