The prognostic value of elevated neutrophil–lymphocyte ratio for cardiac surgery‐associated acute kidney injury: A systematic review and meta‐analysis

Wheatley, Joseph; Liu, Zhengyang; Loth, Joel; Plummer, Mark P.; Penny-Dimri, Jahan C.; Segal, Reny; Smith, Julian A.; Perry, Luke A

doi:10.1111/aas.14170

Cited by 13 publications

(4 citation statements)

References 85 publications

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“…The importance of renal functions in cardiovascular diseases and patients undergoing open heart surgery has been shown by numerous studies 13 . The relationship between low GFR level and the development of surgical reexploration in our own patient population shows how important preoperative renal function evaluation is.…”

Section: Discussionmentioning

confidence: 99%

Impact of Naples Prognostic Score on the development of surgical reexploration in open heart surgery patients

Karaçalılar,

Dinler,

İnci

et al. 2024

Dicle Tıp Dergisi

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Background: Significant and minor perioperative bleeding is common in patients undergoing open heart surgery. Perioperative bleeding has become an important prognostic indicator. Naples Prognostic Score (NPS); It is an effective tool that can be used to detect malnutrition, calculated according to serum albumin level, total cholesterol amount, neutrophil-lymphocyte ratio (NLR), and lymphocyte-monocyte ratio (LMR). In our study,we were planned to evaluate malnutrition and show its negative effects by using the NPS score in patients undergoing open heart surgery. Methods and Results: For the study, a total of 2071 patients who underwent open heart surgery were examined in detail randomly, sequentially and retrospectively. A total of 1825 patients were examined in detail after the patients covering the exclusion criteria were removed. It was determined that a total of 73 patients underwent surgical reexploration. In 53 (4.3%) of the patients with coronary artery bypass surgery, in 11 (3%) of the patients with heart valve surgery, in 8 (4.7%) of the patients with heart valve surgery combined with coronary artery bypass surgery, It was determined that surgical reexploration was performed in 1 (2.8%) of the other procedures. Multivariate regression model; showed that being in the high NPS score group, increasing age, and female gender were independent determinants of the need for surgical reexploration. It was determined that the need for reexploration was observed in the group with higher NPS score (median 3.18 vs 2.69, p

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Section: Discussionmentioning

confidence: 99%

Impact of Naples Prognostic Score on the development of surgical reexploration in open heart surgery patients

Karaçalılar,

Dinler,

İnci

et al. 2024

Dicle Tıp Dergisi

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“…It has been demonstrated that preoperative NLR elevation is determinative for both postoperative AKI and RRT requirements. [31] However, in patients receiving CABG, a high preoperative NLR was linked to poor baseline renal function. [32] Similar to NLR, preoperative PLR can be used as an independent indicator of AKI following cardiac surgery.…”

Section: Discussionmentioning

confidence: 99%

Systemic immune-inflammation index predicts acute kidney injury after cardiac surgery: a retrospective observational study

Zengin¹

2023

GKDA Derg

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Objectives: Inflammation plays an essential role in the development of postoperative acute kidney injury (AKI) in patients receiving cardiac surgery. The study aims to examine the predictive value of the systemic immune-inflammation index (SII), a new biomarker reflecting systemic inflammation, in the development of AKI following cardiac surgery in patients who had coronary artery bypass grafting (CABG). Methods: Patients who received CABG operation in 2022 were retrospectively examined. The incidence of AKI 7 days postsurgery using Kidney Disease Improving Global Outcomes criteria was the primary outcome. The patients were classified into the AKI (n=160) and non-AKI groups (n=424). Patients were compared in terms of basic clinical features, operative characteristics, postoperative variables, and hematological indices derived from preoperative complete blood count analysis. The ability of SII to predict AKI was assessed using receiver-operating characteristic (ROC) curve analysis. Multivariate logistic regression analysis was used to determine the independent relationship between the development of SII and AKI. Results: In this investigation, the incidence of AKI was 25.6%. eGFR, serum albumin, and hemoglobin were significantly lower in the AKI group, whereas body mass index, hypertension, serum creatinine, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and SII were significantly greater. The preoperative SII cutoff of 651.7 predicted AKI with 65.0% sensitivity and 64.9% specificity. The area under the ROC curve was 0.718 (95% confidence interval 0.676-0.760). Conclusion:Preoperative SII may be a simple, inexpensive, and useful prognostic biomarker in predicting postoperative AKI in patients undergoing CABG.

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“…An emerging field of research aims to inform the diagnosis and prognosis of surgical and inflammatory disease through the investigation of hematological indices [6][7][8][9][10] . The neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are promising biomarkers of systemic inflammation [11][12][13][14] and correlate with disease activity in other inflammatory arthritidies 15 . Furthermore, red cell distribution width (RDW), a measure of heterogeneity in red cell sizes, has also been associated with disease activity in inflammatory arthritis 16 .…”

Section: Introductionmentioning

confidence: 99%

The Significance of Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio, and Red Cell Distribution Width in Osteoarthritis

Raveendran,

Perry,

Bucknill

et al. 2023

JBJS Journal of Orthopaedics for Physician Assistants

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Background: The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW) are routinely available inflammatory biomarkers. Their significance in osteoarthritis (OA) is poorly understood. This is a systematic review, and meta-analysis aimed to determine the association of these biomarkers with the presence and severity of OA. Methods: We searched MEDLINE, EMBASE, and Cochrane library for studies reporting on associations between NLR, PLR, and RDW with OA from October 1, 2022, to November 18, 2022. We generated pooled effect measures using random-effects inverse-variance modeling to compare biomarker levels in patients with OA against healthy controls. We generated pooled effect measures to compare patients with severe OA against mild/moderate OA as defined by the Kellgren-Lawrence grading scale, a classification of OA severity based on radiographic findings. We performed metaregression to explore between-study heterogeneity. Results: We included 20 studies involving 5,109 patients in this review. Both NLR and PLR were significantly elevated in OA. RDW was not significantly elevated with OA presence or severity. Only NLR demonstrated a significant elevation with OA severity. Conclusions: In this systematic review and meta-analysis, both NLR and PLR were associated with the presence of OA, whereas only NLR was associated with the severity of disease.

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The prognostic value of elevated neutrophil–lymphocyte ratio for cardiac surgery‐associated acute kidney injury: A systematic review and meta‐analysis

Cited by 13 publications

References 85 publications

Impact of Naples Prognostic Score on the development of surgical reexploration in open heart surgery patients

Impact of Naples Prognostic Score on the development of surgical reexploration in open heart surgery patients

Systemic immune-inflammation index predicts acute kidney injury after cardiac surgery: a retrospective observational study

The Significance of Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio, and Red Cell Distribution Width in Osteoarthritis

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