The prognostic value of histological typing in nasopharyngeal carcinoma

Cheung, Florence; Chan, Oscar S.H.; Ng, Wai Tong; Chan, Lucy; Lee, Anne; Pang, Siu-Wah

doi:10.1016/j.oraloncology.2011.11.017

Cited by 40 publications

(32 citation statements)

References 8 publications

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“…(21) Non-keratinizing histology, which has a known association with EBV-positivity and improved survival outcomes, constitutes a smaller proportion of cases in the United States compared to endemic areas, where it is the predominant histologic subtype. (22) Our cohort contained relatively few patients with keratinizing histology (8% among those with known histology) compared to older non-endemic series. Twenty-four percent of patients in the Intergroup 0099 cohort, for example, had keratinizing disease.…”

Section: Discussionmentioning

confidence: 99%

Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma

et al. 2016

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Background We report treatment outcomes for a large non-endemic cohort of patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) and chemotherapy. Methods We identified 177 consecutive patients with newly diagnosed, non-metastatic nasopharyngeal cancer treated with definitive IMRT between 1998 and 2011. Endpoints included local, regional, distant control, and overall survival. Results Median follow-up was 52 months. The 3-/5-year actuarial rates of local control, regional control, distant control, and overall survival were 92%/83%, 93%/91%, 86%/83%, and 87%/74%, respectively. The median time to local recurrence was 30 months; the annual hazard of local recurrence did not diminish until the 6th year of follow-up. Conclusion s. Overall, we observed excellent rates of disease control and survival consistent with initially reported results from our institution. Attaining locoregional control in patients with extensive primary tumors remains a significant clinical challenge. With mature follow-up we observed that more than half of observed local relapses occurred after 2 years, a pattern distinct from that of carcinomas arising from other head and neck sites. These findings raise the possibility that patients with NPC may benefit from close follow-up during post-treatment years 3–5.

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Section: Discussionmentioning

confidence: 99%

Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma

et al. 2016

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“…From type I to III, NPC becomes less differentiated, more strongly associated with Epstein-Barr virus (EBV) infection and more sensitive to radiotherapy 6-8. Correct histological classification plays a vital role in guiding treatment and improving prognosis of NPC.…”

Section: Introductionmentioning

confidence: 99%

Proteomic Characterization Reveals a Molecular Portrait of Nasopharyngeal Carcinoma Differentiation

Xiao

et al. 2017

J. Cancer

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Nasopharyngeal carcinoma (NPC) is categorized into three different differentiated subtypes by World Health Organization (WHO). Based on an earlier comparative proteomic database of the three histological subtypes, the study was to deepen our understanding of molecular mechanisms associated with NPC differentiation through bio-information mining. Among the three subtypes were 194 differentially expressed proteins (DEPs) of 725 identified proteins. Two DEPs, heat shock protein family B (small) member 1 (HSPB1) and keratin 5 (KRT5), were validated in a series of NPC tissue samples by using immunohistochemistry. Quantified protein families including keratins, S100 proteins (S100s) and heat shock proteins exhibited characteristic expression alterations. Comparisons of predicted bio-function activation states among different subtypes, including formation of cellular protrusion, metastasis, cell death, and viral infections, were conducted. Canonical pathway analysis inferred that Rho GTPases related signaling pathways regulated the motility and invasion of dedifferentiated NPC. In conclusion, the study explored the proteomic characteristics of NPC differentiation, which could deepen our knowledge of NPC tumorigenesis and allow the development of novel targets of therapeutic and prognostic value in NPC.

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“…This subclassifi cation is generally considered unnecessary, because it lacks clinical signifi cance and lesions may show heterogeneity in different areas in the same biopsy or in different biopsies taken at different time intervals [ 20 , 21 ]. However, a recent study showed worse prognosis with differentiated histology [ 22 ].…”

Section: Nasal Tumors Nasopharyngeal Carcinomamentioning

confidence: 95%

“…7.1f ). High-level expression of ERCC1 may be associated with more aggressive clinical behavior [ 22 ].…”

Section: Nasal Tumors Nasopharyngeal Carcinomamentioning

confidence: 99%

Pediatric Cancer in the Head and Neck

Parham

Kukreja

2014

Pediatric Malignancies: Pathology and Imaging

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The prognostic value of histological typing in nasopharyngeal carcinoma

Cited by 40 publications

References 8 publications

Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma

Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma

Proteomic Characterization Reveals a Molecular Portrait of Nasopharyngeal Carcinoma Differentiation

Pediatric Cancer in the Head and Neck

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