The Programmed Death-1 Receptor, Programmed Death-1 Ligand (PD-1/PD-L1) and Apoptosis in Breast Cancer Patients: A potential Mechanism of Immune Escape
Abstract:Background: Interaction between programmed cell death ligand-1 (PD-L1) and its receptor PD-1 is a major inhibitory pathway in maintaining an immunosuppressive tumor microenvironment. The expression of PD-L1 in various solid tumors is proposed to function in preventing T-cell mediated tumor killing, and activating tumor -suppressive cell populations through different mechanisms. The B-cell Lymphoma-2 (Bcl-2) is a key anti-apoptotic protein has been described as mediators of cancer progression. The expression of… Show more
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