The Projection From Ventral CA1, Not Prefrontal Cortex, to Nucleus Accumbens Core Mediates Recent Memory Retrieval of Cocaine-Conditioned Place Preference

Zhou, Yiming; Yan, Enhui; Cheng, Deqin; Zhu, Huiwen; Liu, Zhiyuan; Chen, Xi; Ma, Lan; Liu, Xing

doi:10.3389/fnbeh.2020.558074

Cited by 14 publications

(7 citation statements)

References 68 publications

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“…DH and VH differ greatly in development, anatomy, circuitry, molecular characteristics, synaptic plasticity, and function [10,22] . Although both are involved in the memory process of MOR addiction, several studies in recent years have suggested that VH plays an important role in the mechanisms of nicotine [22] , cocaine [23] and opioid addiction [6,7,11,24] . The present study further proved that the change of VH-β and γ band power is directly related to the extinction of opioid addiction and the extinction method.…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Extinction for Morphine-CPP on Hippocampal EEG Power Spectrum in Mice

Gao

WANG

et al. 2022

Wuhan Univ. J. Nat. Sci.

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The relationship between hippocampal electroencephalogram (EEG) power spectrum and the extinction of addiction memory was investigated. Forty KM mice (Kunming mice) that had successfully established morphine (MOR)-conditioned place preference (CPP) were divided into four groups: saline-training extinction (SAL-TE), SAL-natural extinction (SAL-NE), MOR-TE, MOR-NE, for extinction treatment and EEG recording in the dorsal and ventral hippocampus (DH/VH). Results show that the CPP score of MOR-TE significantly decreased and the total, β and γ bands power spectrum of MOR-TE was suppressed. Notably, the total power from the VH was more correlated with the extinction method, and the TE total power was always lower than NE in SAL or MOR group. Naloxone enhanced the EEG total power and all bands (DH) or β and γ bands (VH) power in the SAL group. However, in the MOR-TE group, only β and γ bands power in VH increased (P<0.05). The results suggest that TE can promote the extinction of opiate addictive memory more effectively than NE, and the extinction of MOR-CPP may have a stronger correlation with changes of VH-EEG power spectrum.

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Section: Discussionmentioning

confidence: 99%

Effects of Different Extinction for Morphine-CPP on Hippocampal EEG Power Spectrum in Mice

Gao

WANG

et al. 2022

Wuhan Univ. J. Nat. Sci.

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“…Thus, GRIP1 is involved in both cocaine-associated learning and memory, consistent with the finding that GRIP1 regulates electric shock-related learning and memory in the hippocampus ( Tan et al, 2020 ). Meanwhile, the circuit from the hippocampal CA1 to the NAc mediates cocaine-associated memory ( Zhou et al, 2019 , 2020 ); hence, GRIP1 in the NAc may be involved in this circuit to adjust learning and memory in cocaine-induced CPP behavior.…”

Section: Discussionmentioning

confidence: 99%

Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity

Chen

Chen²,

Zhi-rong³

et al. 2022

Front. Cell. Neurosci.

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BackgroundThe nucleus accumbens (NAc) is involved in the expression of cocaine addictive phenotypes, including acquisition, extinction, and reinstatement. In the NAc, D1-medium spiny neurons (MSNs) encode cocaine reward, whereas D2-MSNs encode aversive responses in drug addiction. Glutamate receptor-interacting protein 1 (GRIP1) is known to be associated with cocaine addiction, but the role of GRIP1 in D1-MSNs and D2-MSNs of the NAc in cocaine acquisition and reinstatement remains unknown.MethodsA conditioned place preference apparatus was used to establish cocaine acquisition, extinction, and reinstatement in mouse models. GRIP1 expression was evaluated using Western blotting. Furthermore, GRIP1-siRNA and GRIP1 overexpression lentivirus were used to interfere with GRIP1 in the NAc. After the behavioral test, green fluorescent protein immunostaining of brain slices was used to detect spine density.ResultsGRIP1 expression decreased during cocaine acquisition and reinstatement. GRIP1-siRNA enhanced cocaine-induced CPP behavior in acquisition and reinstatement and regulated associated spine plasticity. Importantly, the decreased GRIP1 expression that mediated cocaine acquisition and reinstatement was mainly driven by the interference of the GRIP1-GluA2 interaction in D1-MSNs and could be blocked by the interference of the GRIP1-GluA2 interaction in D2-MSNs. Interference with the GRIP1-GluA2 interaction in D1- and D2-MSNs decreased spine density in D1- and D2-MSNs, respectively.ConclusionGRIP1 in D1- and D2-MSNs of the NAc differentially modulates cocaine acquisition and reinstatement. GRIP1 downregulation in D1-MSNs has a positive effect on cocaine acquisition and reinstatement, while GRIP1 downregulation in D2-MSNs has a negative effect. Additionally, GRIP1 downregulation in D1-MSNs plays a leading role in cocaine acquisition and reinstatement.

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“…There is some evidences indicating the role of the NAc shell in the acquisition of CPP [ 31 , 51 ]. However, there are also studies showing the involvement of the NAc Core too [ 31 , 52 – 54 ]. In addition, some studies have shown the role of whole NAc in this issue including our previous studies [ 5 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats

et al. 2021

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Background The nucleus accumbens (NAc) plays a principal role in drug reward. It has been reported that metabotropic glutamate receptors (mGlu receptors) play a key role in the rewarding pathway(s). Previous studies have shown the vast allocation of the different types of mGlu receptors, including mGlu8 receptors, in regions that are associated with opioid rewards, such as the NAc. The aim of the present study was to evaluate the role of mGlu8 receptors within the NAc in the acquisition and expression phases of morphine induced conditioned place preference (CPP). Adult male Wistar rats were bilaterally implanted by two cannulas' in the NAc and were evaluated in a CPP paradigm. Selective mGlu8 receptor allosteric agonist (S-3,4-DCPG) was administered at doses of 0.03, 0.3, and 3 μg/0.5 μL saline per side into the NAc on both sides during the 3 days of morphine (5 mg/kg) conditioning (acquisition) phase, or before place preference test, or post-conditioning (expression) phase of morphine-induced CPP. Results The results revealed that intra-accumbal administration of S-3,4-DCPG (0.3 and 3 μg) markedly decreased the acquisition in a dose-dependent manner but had no effect on expression of morphine-induced CPP. Conclusions The findings suggest that activation of mGlu8 receptors in the NAc dose-dependently blocks the establishment of morphine-induced CPP and reduces the rewarding properties of morphine which may be related to the glutamate activity into the NAc and in reward pathway(s). These data suggest that mGlu8 receptor may be involved in conditioned morphine reward.

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The Projection From Ventral CA1, Not Prefrontal Cortex, to Nucleus Accumbens Core Mediates Recent Memory Retrieval of Cocaine-Conditioned Place Preference

Cited by 14 publications

References 68 publications

Effects of Different Extinction for Morphine-CPP on Hippocampal EEG Power Spectrum in Mice

Effects of Different Extinction for Morphine-CPP on Hippocampal EEG Power Spectrum in Mice

Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity

The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats

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