The �Prolactin-Model� in Schizophrenic Patients: Further Studies on the Pharmacodynamics of Neuroleptic Drugs1

Chlorpromazine, Haloperidol, Metoclopramide and Domperidone Release Prolactin Through Dopamine Antagonism at Low Concentrations but Paradoxically Inhibit Prolactin Release at High Concentrations

“…In addition, all 4 drugs act at high concentrations to suppress directly pituitary prolactin secretion by an as yet undefined mechanism. Recent data indicate that haloperidol in vivo may initially increase prolactin secretion, but that there may then be a fall in the serum prolactin if the haloperidol administration continues (Langer, 1979). It is intriguing to speculate that this fall may, at least in part, be due to the intrinsic prolactin-suppressing action of high concentrations of haloperidol.…”

Διερευνηση Των Βιολογικων Και Κλινικων Επιδρασεων Της Βρωμοκρυπτινης Σε Συνδυασμο Με Νευροληπτικα Σε Χρονιους Σχιζοφρενεις

“…1976Naber καί συν. 1980, Meltzer 1979β καί 1980β, Rubin καί Hays 1979, Trimble 1980, Langer 1979). Επίσης ανυψωμένα επίπεδα προλακτίνης έχουν διαπιστωθεί ΰστερα άπό αγωγή μέ ηλεκτροσόκ (Ohman καί συν.…”