The Prophylactic Effect of Probiotic Enterococcus lactis IW5 against Different Human Cancer Cells

Nami, Yousef; Haghshenas, Babak; Haghshenas, Minoo; Abdullah, Norhafizah; Khosroushahi, Ahmad Yari

doi:10.3389/fmicb.2015.01317

Cited by 71 publications

(45 citation statements)

References 40 publications

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“…The carbohydrate fermentation profile and enzymatic activities of the B. amyloliquefaciens US573 strain were investigated by using API‐ZYM and API 50CHB kits. The US573 isolate exhibited no harmful enzymatic activities such as α‐chymotrypsin, β‐glucuronidase, β‐glucosidase and N ‐acetyl‐β‐glucosaminidase, which indicates that this strain is safe for probiotic use . According to the results of carbohydrate metabolism, 14 types of sugar were fermented by the US573 bacterium, as shown in Table .…”

Section: Resultsmentioning

confidence: 90%

“…The US573 isolate exhibited no harmful enzymatic activities such as -chymotrypsin, -glucuronidase, -glucosidase and N-acetyl--glucosaminidase, which indicates that this strain is safe for probiotic use. 55,56 According to the results of carbohydrate metabolism, 14 types of sugar were fermented by the US573 bacterium, as shown in Table 2. Of particular interest, the hydrolysis of oligosaccharides (raffinose) and disaccharides (e.g.…”

Section: Profiles Of Fermentation and Enzymatic Activitiesmentioning

confidence: 99%

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Assessment of the potential of the multi‐enzyme producer Bacillus amyloliquefaciens US573 as alternative feed additive

et al. 2017

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Section: Resultsmentioning

confidence: 90%

Section: Profiles Of Fermentation and Enzymatic Activitiesmentioning

confidence: 99%

Assessment of the potential of the multi‐enzyme producer Bacillus amyloliquefaciens US573 as alternative feed additive

et al. 2017

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“…The health benefits of specific strains of Enterococcus faecalis and Enterococcus faecium were characterized ( Hlivak et al, 2005 ; Franz et al, 2011 ; Cebrián et al, 2012 ; Hanchi et al, 2018 ; Zommiti et al, 2018 ). Some strains of E. faecalis and E. faecium and some others strains belonging to the species Enterococcus durans , Enterococcus hirae , Enterococcus lactis , and Enterococcus munditii had the potential to promote health to their hosts ( Nami et al, 2014 ; Pieniz et al, 2014 ; Nami et al, 2015 ; Gupta and Tiwari, 2015 ; Haghshenas et al, 2016 ; van Zyl et al, 2016 ). However, extensive studies for safety regulation is required upon application.…”

Section: Introductionmentioning

confidence: 99%

Enterococcus faecalis Is a Better Competitor Than Other Lactic Acid Bacteria in the Initial Colonization of Colon of Healthy Newborn Babies at First Week of Their Life

Morsy

2020

Front. Microbiol.

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Initial colonization of human gut by bacteria is an important step in controlling its microbiota and health status. This study followed the initial colonization by lactic acid bacteria (LAB) in colon of new born babies through following its occurrence in their stool at first week of their life. The LAB occurrence in the neonates’ stool was followed on MRS agar medium. The isolated LAB from male and female newborn babies of normal birth and cesarean section surgical delivery were molecular biologically identified by phylogenetic analysis of 16S rRNA gene sequence. From the 24 investigated newborn babies, three LAB taxa, Lactobacillaceae , Enterococcus , and Streptococcus , were detected in their stool at first week of their life. Lactobacillaceae represented 20.8% of total colonized LAB in newborn babies in the culture-dependent approach used in this study and included three species namely Limosilactobacillus reuteri (previously known as Lactobacillus reuteri ), Lacticaseibacillus rhamnosus (previously known as Lactobacillus rhamnosus ) and Ligilactobacillus agilis (previously known as Lactobacillus agilis ). Enterococcus faecalis and E. faecium were detected where E. faecalis was the highest dominant, representing 62.5% of total LAB colonizing newborn babies. This result suggests that this bacterium has high potency for colonization and might be important for controlling the initial settlement of microbiota in healthy newborn babies. Only one species of Streptococcus namely Streptococcus agalactiae was detected in 8.33% total of the investigated newborn babies indicating high competency by other LAB for colonization and that this bacteria, in spite of its pathogenicity, is commensal in its low existence in healthy babies. The explored potency of natural initial colonization of the LAB species E. faecalis , E. faecium , L. reuteri , L. rhamnosus , and L. agilis of which many health beneficial strains were previously reported, would be important for future applications. Despite the controversy in evaluating its health benefits, E. faecalis as a potent competitor to other LAB refers to its importance in initial colonization of healthy babies colon at first week of their life. Further future studies, with more number of samples and characterization, would be of importance for evaluating the potential use of beneficial Enterococcus strains which could improve intestinal ecosystem.

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“…Another study [ 85 ] found that the kefir product containing Lactobacillus kefiri possessed apoptotic effect on myeloid leukaemia cell lines. In addition, Enterococcus lactis IW5 which was obtained from human gut strongly inhibited the growth of several pathogenic bacteria and decreased the viability of different cancer cells, such as HeLa, MCF-7, AGS, HT-29, and Caco2, representing the potential therapeutic effect of probiotic on cancer patients [ 86 ].…”

Section: Probiotic and Cancermentioning

confidence: 99%

Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases

Nazir

Hussain

Hamid

et al. 2018

BioMed Research International

126

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The potential health benefits of probiotics have long been elucidated since Metchnikoff and his coworkers postulated the association of probiotic consumption on human's health and longevity. Since then, many scientific findings and research have further established the correlation of probiotic and gut-associated diseases such as irritable bowel disease and chronic and antibiotic-associated diarrhea. However, the beneficial impact of probiotic is not limited to the gut-associated diseases alone, but also in different acute and chronic infectious diseases. This is due to the fact that probiotics are able to modify the intestinal microbial ecosystem, enhance the gut barrier function, provide competitive adherence to the mucosa and epithelium, produce antimicrobial substances, and modulate the immune activity by enhancing the innate and adaptive immune response. Nevertheless, the current literature with respect to the association of probiotic and cancer, high serum cholesterol, and allergic and HIV diseases are still scarce and controversial. Therefore, in the present work, we reviewed the potential preventive and therapeutic role of probiotics for cancer, high serum cholesterol, and allergic and HIV diseases as well as providing its possible mechanism of actions.

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The Prophylactic Effect of Probiotic Enterococcus lactis IW5 against Different Human Cancer Cells

Cited by 71 publications

References 40 publications

Assessment of the potential of the multi‐enzyme producer Bacillus amyloliquefaciens US573 as alternative feed additive

Assessment of the potential of the multi‐enzyme producer Bacillus amyloliquefaciens US573 as alternative feed additive

Enterococcus faecalis Is a Better Competitor Than Other Lactic Acid Bacteria in the Initial Colonization of Colon of Healthy Newborn Babies at First Week of Their Life

Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases

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