The Protective Effect of Bee Venom on Fibrosis Causing Inflammatory Diseases

Osteoarthritis is one of the most common rheumatic disease in the world and one of the leading causes of disability in the elderly. There is still no curative management for the disease, so the search for new therapeutic alternatives continues. Apitherapy is a therapeutic tool based on the use of beehive products used since ancient times and, at present, their mechanism of action begins to be known. Many of the mechanisms of action of the beehive products are useful for chronic articular pathophysiological processes such as those described in osteoarthritis. This article presents a review of the current state of understanding of the mechanisms through which bee venom, propolis, honey, pollen, and royal jelly may act on osteoarthritis. © 2020 S. Karger AG, Basel Apitherapie bei Osteoarthritis: Perspektiven aus der GrundlagenforschungSchlüsselwörter Apitherapie · Osteoarthritis · Bienengift · Bienenprodukte · Komplementär-und Alternativmedizin ZusammenfassungOsteoarthritis ist eine der weltweit häufigsten rheumatischen Erkrankungen und eine der führenden Ursachen für körperliche Beeinträchtigung im Alter. Eine kurative Behandlungsoption steht bis heute nicht zur Verfügung, daher wird weiter nach therapeutischen Alternativen gesucht. Die Apitherapie ist ein therapeutisches Instrument, das auf der Anwendung von Bienenprodukten beruht, die seit dem Altertum verwendet werden und deren Wirkmechanismen wir gerade beginnen zu verstehen. Viele dieser Mechanismen, über die die Bienenprodukte ihre Wirkung entfalten, spielen eine nützliche Rolle in pathophysiologischen Prozessen von chronischen Gelenkerkrankungen wie zum Beispiel der Osteoarthritis. Dieser Artikel gibt einen Überblick über den aktuellen Kenntnisstand der Mechanismen, über die Bienengift, Propolis, Honig, Pollen und Gelée royale bei Osteoarthritis wirken könnten.

show abstract

“…Modulation of Growth Factor Release BV modulates the effect of TGF-B preventing tissue replacement by nonfunctional connective tissue [80].…”

Section: Alteration Of Mitochondrial Functionmentioning

confidence: 99%

Apitherapy for Osteoarthritis: Perspectives from Basic Research

2020

View full text Add to dashboard Cite

show abstract

“…(When used incorrectly it can lead to allergic reactions of different intensities [3,4]). In fact, the target product of this study is used in the pharmaceutical industry, in the treatment of several diseases [4,5], such as cancer [2,6,7], HIV, multiple sclerosis, arthritis, bursitis, tendonitis, dissolution of scar tissue, herpes zoster, joint diseases and rheumatoid arthritis, Lyme disease, and osteoarthritis [8]. Another field of application is the cosmetics market [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Productivity and Economic Analysis of a New Intensive Collector in the Portuguese Market with Implication of Open Innovation Perspective

Serrinha

Correia

Marques

2019

Journal of Open Innovation: Technology, Market, and Complexity

View full text Add to dashboard Cite

Bee venom is a sub-product of the beekeeping activity, and has a wide field of applications in several pivotal markets. Nevertheless, its collection is not an activity disseminated among Portuguese beekeepers, as its production is marginal. There are limited empirical studies on the production and the technical aspects involved in this type of activity. Our study, therefore, contributes to narrowing this knowledge gap, by analyzing and comparing the productivity and profitability of two bee venom collection techniques. The first involves equipment available on the market, and the second involves a new device developed from the aim of the present work. Concerning market knowledge, a questionnaire was given to a sample of beekeepers, to understand and characterize the market's needs and the level of information about bee venom. Because of the growing market interest in this product, a new collector is proposed, based on a set of intensive frame collectors strategically placed inside the beehives. The improvements obtained were increased production, either in terms of quantity or quality, obtaining a positive profitability. To evaluate the productivity of the proposed equipment, a comparison was performed, in an apiary, between existing state-of-the-art equipment and the proposed intensive collector. In a second stage, the profitability of the new proposed equipment was analyzed, using a comparative method between incomes and costs associated with both solutions. The results obtained showed that the new intensive collector enables a profitable collection of bee venom in Portugal, despite its higher initial investment.

show abstract

“…The lethal outcome comes most often from the paralysis of the respiratory center [13,14]. Because of anticoagulant and anti-inflammatory properties, bee venom is mainly used to treat many inflammatory diseases such as arthritis, bursitis, herpes zoster, joint disease and rheumatoid arthritis Lyme disease, multiple sclerosis and osteoarthritis [16,17,18,19,20,21,22], Proceeding from a few studies on the effect of bee venom on the life expectancy of experimental animals exposed to radiation a number of issues remain unexplored and is of great scientific and practical interest. Analyzing the literature data on the degree of study of the venom of honey bees, the aim of the studies was to study the radioprotective effect of the pre-introduced zootoxin Apis mellifera Caucasica with a single gamma irradiation of 60Co mice at doses of 1.3, 5, 7, 10 Gy at irradiation dose rates of 1 Gr / min.…”

Section: Introductionmentioning

confidence: 99%