The Protective Effect of Curcumin on Hepatotoxicity and Ultrastructural Damage Induced by Cisplatin

Wang, Ying; Hu, Peng-Chao; Gao, Fangfang; Xu, Shuai; Kuang, Changchun; Wei, Lei; Zhang, Jingwei

doi:10.3109/01913123.2014.933289

Cited by 20 publications

(19 citation statements)

References 17 publications

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“…They also found that pretreatment of curcumin prior to cisplatin could prevent cisplatin-induced hepatotoxicity in rat model ( Waseem et al, 2014 ). Wang et al (2014) investigated the effect of curcumin on cisplatin-induced hepatotoxicity and ultrastructural damage. Their results showed that cisplatin had significant liver damage with vacuolated cytoplasm and blurred trabecular structure after cisplatin (50 mg/kg/day) was injected via i.p to Kunming mice for 10 days, and curcumin treatment (200 mg/kg/day) for 10 days could prevent cisplatin-induced liver damage ( Wang et al, 2014 ).…”

Section: The Preventive Effects Of Curcumin Against Chemotherapy-indumentioning

confidence: 99%

Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects

et al. 2018

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Cancer is still a severe threat to the health of people worldwide. Chemotherapy is one of main therapeutic approaches to combat cancer. However, chemotherapy only has a limited success with severe side effects, especially causing damage to normal tissues such as bone marrow, gastrointestine, heart, liver, renal, neuron, and auditory tissues, etc. The side-effects limit clinical outcome of chemotherapy and lower patients’ quality of life, and even make many patients discontinue the chemotherapy. Thus, there is a need to explore effective adjuvant strategies to prevent and reduce the chemotherapy-induced side effects. Naturally occurring products provide a rich source for exploring effective adjuvant agents to prevent and reduce the side effects in anticancer chemotherapy. Curcumin is an active compound from natural plant Curcuma longa L., which is widely used as a coloring and flavoring agent in food industry and a herbal medicine in Asian countries for thousands of years to treat vomiting, headache, diarrhea, etc. Modern pharmacological studies have revealed that curcumin has strong antioxidative, anti-microbial, anti-inflammatory and anticancer activities. Growing evidence shows that curcumin is able to prevent carcinogenesis, sensitize cancer cells to chemotherapy, and protect normal cells from chemotherapy-induced damages. In the present article, we review the preventive effect of curcumin against chemotherapy-induced myelosuppression, gastrointestinal toxicity, cardiotoxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, ototoxicity, and genotoxicity, and discuss its action mechanisms.

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Section: The Preventive Effects Of Curcumin Against Chemotherapy-indumentioning

confidence: 99%

Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects

et al. 2018

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“…Therefore, we and others have shown that the use of natural molecules such as polyphenols can modulate xenobiotic-metabolizing enzymes as well as the pathways leading to cancer cell death, making it possible to restore sensitization to anticancer agents. For example, resveratrol, curcumin, vitamin E, and gallic acid are able to protect cells from cisplatin-induced genotoxicity [13][14][15]. Very interestingly, some of these natural compounds are able to synergize at the same time with various anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent

Scagliarini

Mathey

Aires

et al. 2020

Cells

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In spite of chemotherapy and systematic screening for people at risk, the mortality rate of colorectal cancer (CRC) remains consistently high, with 600,000 deaths per year. This low success rate in the treatment of CRC results from many failures associated with high resistance and the risk of metastasis. Therefore, in response to these therapeutic failures, new strategies have been under development for several years aimed at increasing the effect of anticancer compounds and/or at reducing their secondary effects on normal cells, thus enabling the host to better withstand chemotherapy. This study highlights that xanthohumol (Xn) concentrations under the IC50 values were able to induce apoptosis and to enhance the DNA-damage response (DDR). We demonstrate for the first time that Xn exerts its anticancer activity in models of colon cancer through activation of the ataxia telangiectasia mutated (ATM) pathway. Subsequently, the ability of Xn to restore DNA damage in CRC cells can sensitize them to anticancer agents such as SN38 (7-ethyl-10-hydroxycamptothecin) used in chemotherapy.

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“…The tumor sections were collected and fixed in 4% paraformaldehyde. Paraffin-embedded tissue sections (5 mm) were stained with H&E, according to standard techniques (35). Images were captured using a Nikon Eclipse Ci light microscope (Nikon Instruments, Inc., Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

“…Samples were dehydrated in a graded ethanol series, embedded in Epon 812 (SPI Supplies/Structure Probe, Inc., West Chester, PA, USA). The sections were examined under by transmission electron microscopy (35).…”

Section: Methodsmentioning

confidence: 99%

TNF‑α inhibits xenograft tumor formation by A549 lung cancer cells in nude mice via the HIF‑1α/VASP signaling pathway

Chen

et al. 2019

Oncol Rep

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Lung cancer is the leading cause of cancer-associated mortality worldwide. Tumor necrosis factor α (TNF-α) is an important cytokine in the tumor microenvironment that serves a function in the balance of cell survival and cell death pathways. Our previous studies indicated that hypoxia-inducible factor 1α (HIF-1α) acts downstream of TNF-α in MCF-7 luminal breast cancer cells. However, whether vasodilator-stimulated phosphoprotein (VASP) is implicated in the direct regulation of HIF-1α in response to TNF-α in lung cancer remains unknown. In vitro studies were performed using A549 and H226 lung carcinoma cells and in vivo studies of tumor xenograft models were performed to investigate the effects of TNF-α. The results demonstrated that TNF-α decreased VASP expression by upregulating the expression of HIF-1α to inhibit A549 cell proliferation and adhesion. Inhibition of transplanted tumor growth was associated with downregulation of VASP expression in nude mice. Bioinformatics analysis indicated that expression levels of VASP or HIF-1α lead to differential outcomes of overall survival in lung carcinoma. These results suggest that the HIF-1α/VASP signaling pathway serves an important function in the regulation of TNF-α-induced suppression of A549 cell proliferation and xenograft growth. This may improve our understanding of the antitumor effect of TNF-α.

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The Protective Effect of Curcumin on Hepatotoxicity and Ultrastructural Damage Induced by Cisplatin

Cited by 20 publications

References 17 publications

Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects

Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects

Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent

TNF‑α inhibits xenograft tumor formation by A549 lung cancer cells in nude mice via the HIF‑1α/VASP signaling pathway

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