The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice

Investigation of the Biochemical and Histological Changes Induced by Zearalenone Mycotoxin on Liver in Male Mice and the Protective Role of Crude Venom Extracted from Jellyfish <i>Cassiopea Andromeda</i>

“…The γ globulin fraction was decreased by ZEN after 48 hours and two weeks. This finding is in agreement with Abbès et al [37], who found a decrease in both IgA and IgG immunoglobulin concentrations in mice administered ZEN. In general, the present data confirmed that ZEN and its metabolites have may a direct effect on protein synthesis in the liver.…”

“…Similar association between increased level of hepatic enzymes and cell necrosis were described by many investigators especially with mycotoxin hepatotoxicity [37]. Bi-nucleated hepatocytes were also observed after ZEN administration and more frequently after one week.…”

Adverse Haemato-Biochemical Effects of Chlorinated Insecticide in Adult Male Rats.

“…In addition, decreased WBC and PLT counts observed in the present study were probably due to harmful effects of DDT on bone marrow and hematopoietic organs. Moreover, the decline in PLT counts suggested a possible effect on blood coagulation and haemostasis blood system damage (Abbes et al, 2006). In view of these points, it is considered that adverse actions of DDT targeting immune and haematopoietic systems might also be responsible for thymic atrophy and hypocellularity in the bone marrow and decreased levels of PLT in the present study.…”

Broiler Tavuklarda Aflatoksin ile Kontamine Diyette Ticari Toksin Bağlayıcı, Doğal Probiyotik Türleri, Maya Hücre Duvarı ve Aluminosilikatın GOT2 ve CYP450 1A5 Gen Ekspresyonları İle Karaciğer Enzimlerinin Serum Konsantrasyonları Üzerine Etkisi

“…Aflatoxins are the reason of a wide range of metabolic damages, including, liver lesions, changes in genes expression especially liver enzymes and genes involved in the metabolism of this toxin [28] . Measuring the amount of serum concentrations of liver enzymes is a good way to assess liver damages [29] . Some researchers showed that consuming aflatoxin will increase the concentration of liver enzymes especially AST, ALT and LDH [10] .…”