The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies

Li, Yong; Zhu, Senbo; Luo, Junchao; Tong, Yu; Zheng, Yanfang; Ji, Lichen; He, Zeju; Jing, Qiangan; Huang, Jiaqing; Zhang, Yinjun; Bi, Qing

doi:10.2147/dddt.s407122

Cited by 7 publications

(1 citation statement)

References 74 publications

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“…Lipid metabolism is also critical to the occurrence of ferroptosis. Reactive oxygen species are a group of partially reduced oxygen-containing molecules, including superoxide anion (O 2− ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (OH), which are critical for preserving the stability of cells and tissues ( Li Y. et al, 2023 ). The accumulation of lipid ROS is a signature feature of the increased ferritin.…”

Section: Metabolic Mechanisms Of Ferroptosismentioning

confidence: 99%

Ferroptosis: a new regulatory mechanism in neuropathic pain

Li,

Guo,

Gao

et al. 2023

Front. Aging Neurosci.

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Neuropathic pain (NP) is pain caused by damage to the somatosensory system. It is a common progressive neurodegenerative disease that usually presents with clinical features such as spontaneous pain, touch-evoked pain, nociceptive hyperalgesia, and sensory abnormalities. Due to the complexity of the mechanism, NP often persists. In addition to the traditionally recognized mechanisms of peripheral nerve damage and central sensitization, excessive iron accumulation, oxidative stress, neuronal inflammation, and lipid peroxidation damage are distinctive features of NP in pathophysiology. However, the mechanisms linking these pathological features to NP are not fully understood. The complexity of the pathogenesis of NP greatly limits the development of therapeutic approaches for NP. Ferroptosis is a novel form of cell death discovered in recent years, in which cell death is usually accompanied by massive iron accumulation and lipid peroxidation. Ferroptosis-inducing factors can affect glutathione peroxidase directly or indirectly through different pathways, leading to decreased antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. It has been shown that ferroptosis is closely related to the pathophysiological process of many neurological disorders such as NP. Possible mechanisms involved are changes in intracellular iron ion levels, alteration of glutamate excitability, and the onset of oxidative stress. However, the functional changes and specific molecular mechanisms of ferroptosis during this process still need to be further explored. How to intervene in the development of NP by regulating cellular ferroptosis has become a hot issue in etiological research and treatment. In this review, we systematically summarize the recent progress of ferroptosis research in NP, to provide a reference for further understanding of its pathogenesis and propose new targets for treatment.

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Section: Metabolic Mechanisms Of Ferroptosismentioning

confidence: 99%

Ferroptosis: a new regulatory mechanism in neuropathic pain

Li,

Guo,

Gao

et al. 2023

Front. Aging Neurosci.

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Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation

Fan,

Wang,

Zhang

et al. 2024

Pain Ther

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In vivo evaluation of selenium-tellurium based nanoparticles as a novel treatment for bovine mastitis

Kosaristanova,

Bytesnikova,

Fialova

et al. 2024

J Animal Sci Biotechnol

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Background Bovine mastitis is one of the main causes of reduced production in dairy cows. The infection of the mammary gland is mainly caused by the bacterium Staphylococcus aureus, whose resistant strains make the treatment of mastitis with conventional antibiotics very difficult and result in high losses. Therefore, it is important to develop novel therapeutic agents to overcome the resistance of mastitis-causing strains. In this study, novel selenium-tellurium based nanoparticles (SeTeNPs) were synthesized and characterized. Their antibacterial activity and biocompatibility were evaluated both in vitro and in vivo using a bovine model. A total of 10 heifers were divided into experimental and control groups (5 animals each). After intramammary infection with methicillin resistant S. aureus (MRSA) and the development of clinical signs of mastitis, a dose of SeTeNPs was administered to all quarters in the experimental group. Results Based on in vitro tests, the concentration of 149.70 mg/L and 263.95 mg/L of Se and Te, respectively, was used for application into the mammary gland. Three days after SeTeNPs administration, MRSA counts in the experimental group showed a significant reduction (P < 0.01) compared to the control group. The inhibitory effect observed within the in vitro experiments was thus confirmed, resulting in the suppression of infection in animals. Moreover, the superior biocompatibility of SeTeNPs in the organism was demonstrated, as the nanoparticles did not significantly alter the inflammatory response or histopathology at the site of application, i.e., mammary gland, compared to the control group (P > 0.05). Additionally, the metabolic profile of the blood plasma as well as the histology of the main organs remained unaffected, indicating that the nanoparticles had no adverse effects on the organism. Conclusions Our findings suggest that SeTeNPs can be used as a promising treatment for bovine mastitis in the presence of resistant bacteria. However, the current study is limited by its small sample size, making it primarily a proof of the concept for the efficacy of intramammary-applied SeTeNPs. Therefore, further research with a larger sample size is needed to validate these results.

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The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies

Cited by 7 publications

References 74 publications

Ferroptosis: a new regulatory mechanism in neuropathic pain

Ferroptosis: a new regulatory mechanism in neuropathic pain

Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation

In vivo evaluation of selenium-tellurium based nanoparticles as a novel treatment for bovine mastitis

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