The protective effect of syringic acid on dextran sulfate sodium‐induced experimental colitis in BALB/c mice

Fang, Wen‐Hui; Zhu, Shihong; Niu, Zhongbao; Yin, Yuti

doi:10.1002/ddr.21524

Cited by 31 publications

(20 citation statements)

References 36 publications

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“…Additionally, symptoms and weight loss present significant amelioration in mice induced by DSS under the treatment with syringic acid (25 mg/ kg) extracted from clove. What's more, its application decreases the expressions of NF-κBp65 and IκB in LPSinduced RAW 264.7 cells, thus reducing the activation and nuclear accumulation of p-STAT-3Y705, which contributes to inhibitions of IκB degradation and the nuclear translocation of NF-κBp65 in colonic tissue [73].…”

Section: Interior-warming and Drying Dampness Medicinementioning

confidence: 98%

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Zhao

2020

Chin Med

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Nuclear factor-kappa B (NF-κB) is a kind of multi-functional nuclear transcription factor involved in regulating gene transcription to influence pathological evolution of inflammatory and immune diseases. Numerous literature evidence that NF-κB pathway plays an essential role in pathogenic development of ulcerative colitis (UC). UC is a chronic non-specific inflammatory bowel disease, and until now, therapeutic agents for UC including aminosalicylates, corticosteroids and immune inhibitors still cannot exert satisfied effects on patients. In recent years, Chinese medicines suggest the advantages of alleviating symptoms and signs, decreasing side-effects and recurrence, whose one of mechanisms is related to regulation of NF-κB pathway. In this review, we categorize Chinese medicines according to their traditional therapeutic functions, and summarize the characteristics of Chinese medicines targeting NF-κB pathway in UC treatment. It indicates that 85 kinds of Chinese medicines' compounds and formulae can directly act on NF-κBp65; while 58 Chinese medicines' ingredients and formulae indirectly suppress NF-κBp65 by regulation of its upstream or other related pathways. Moreover, by the analysis of Chinese medicines' category based on their traditional functions, we conclude the category of dampness-drying and detoxificating medicine targeting NF-κB pathway accounts for primary status for amelioration of UC. Simultaneously, this review also contributes to the choices of Chinese medicine category and provides curative potential of Chinese medicines for clinical UC treatment.

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Section: Interior-warming and Drying Dampness Medicinementioning

confidence: 98%

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Zhao

2020

Chin Med

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“… 2018 ) and induces the expression of TNF-α, IL-1β, and IL-6 (Fang et al. 2019 ). NF-κB inhibitors significantly reduce the infiltration of inflammatory cells and repress the expression of TNF-α, IL-6, and other inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…NF-jB regulates target gene transcription and promotes the generation of numerous inflammatory cytokines, growth factors, and acute phase proteins including TNF-a and IL-1b. NF-jB is highly expressed in IBD, where it plays an important role (Colombo et al 2018) and induces the expression of TNF-a, IL-1b, and IL-6 (Fang et al 2019). NF-jB inhibitors significantly reduce the infiltration of inflammatory cells and repress the expression of TNF-a, IL-6, and other inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Effects of Jian Pi Qing Chang Hua Shi decoction on mucosal injuries in a 2,4,6-trinitrobenzene sulphonic acid-induced inflammatory bowel disease rat model

Zhang

Ta²,

Shen

et al. 2021

Pharmaceutical Biology

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Context Jian Pi Qing Chang Hua Shi decoction (JPQCHSD) has been considered as an effective remedy for the treatment of inflammatory bowel disease (IBD) in Chinese traditional medicine. Objective We evaluated the efficacy of JPQCHSD on 2-4-6-trinitrobenzene sulphonic acid (TNBS)-induced IBD rats and the responsible mechanisms. Materials and methods Except the rats of the control group (50% ethanol), Sprague–Dawley rats (180 ± 20 g) induced by TNBS (150 mg/kg in 50% ethanol), received water extract of JPQCHSD daily at 0, 9.5, 19, or 38 g/kg for 12 days. The rats were sacrificed, and their colons were removed to evaluate the disease activity index. Malondialdehyde (MDA), superoxide dismutase (SOD), myeloperoxidase (MPO), immunoglobulin A (IgA), tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and nuclear factor-κB were evaluated. Results JPQCHSD extract significantly reduced the disease activity index of TNBS-induced colitis with a median effective dose (ED 50 ) of 26.93 g/kg. MPO and MDA were significantly reduced in the 19 and 38 g/kg groups (ED 50 values 37.38 and 53.2 g/kg, respectively). The ED 50 values for the increased SOD and IgA were 48.98 and 56.3 g/kg. ED 50 values for inhibition of TNF-α, IL-1β, and IL-6 were 32.66, 75.72, and 162.06 g/kg, respectively. Discussion JPQCHSD promoted mucosal healing in IBD rats via its anti-inflammation, immune regulation, and antioxidation properties. Conclusions JPQCHSD has healing function on IBD. Further clinical trials are needed to demonstrate its efficacy and tolerance to IBD.

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“…Syringic acid has anti-oxidant, anti-endotoxin, and anti-bacterial, anti-cancer and also has cardio protective effect [66,67].…”

Section: Various Effects Of Phenolic Substancesmentioning

confidence: 99%

Aspergillus alliaceus infection fatally shifts Orobanche hormones and phenolic metabolism

Aybeke

2020

Braz J Microbiol

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In this study, the physio pathological effects of Aspergillus alliaceus (Aa, fungi, biocontrol agent) on Orobanche (parasitic plant) were investigated by hormone and phenolic substance tests. In experimental group, Orobanches were treated with the fungi, considering control group was fungus-free. Based on the hormonal tests, in the experimental group, salicylic acid (SA), jasmonic acid (JA), abscisic acid (ABA) and gibberellic acid (GA) levels significantly decreased, and only indole acetic acid (IAA) hormone levels were fairly higher than the control group. According to phenolic substance tests, it was found that only gallic acid, syringic acid and caffeic acid values significantly increased compared with control, and catechin and p-coumaric acid values were significantly lower. Consequently, it was determined that Aa pathogenesis (1) considerably reduces the effects of all defence hormones (JA, ABA, SA), (2) operates an inadequate defence based solely on the IAA hormone and several phenolic substances (gallic acid, syringic acid and caffeic acid), (3) and inevitably the fungi lead the Orobanche to a slow and continuous death. The results were evaluated in detail in the light of similar recent article and current literature in terms of biocontrol and pathology.

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The protective effect of syringic acid on dextran sulfate sodium‐induced experimental colitis in BALB/c mice

Cited by 31 publications

References 36 publications

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Effects of Jian Pi Qing Chang Hua Shi decoction on mucosal injuries in a 2,4,6-trinitrobenzene sulphonic acid-induced inflammatory bowel disease rat model

Aspergillus alliaceus infection fatally shifts Orobanche hormones and phenolic metabolism

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