The Protective Effects of Buzui on Acute Alcoholism in Mice

Chen, Chen; Wen, Da-Chao; Gao, Shu-di; Hu, Xiaoyu; Yi, Cheng

doi:10.1155/2016/3539748

Cited by 10 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As showed in Table 3 , there was a significant rise of levels of AST and ALT in serum 6 h after alcohol consumption (control group) when compared with the normal group. In the literature [ 18 , 19 , 20 ], 6 h were usually adopted for evaluation of AST and ALT levels, and some researchers even found that the level of ALT was the highest among 1.5, 3, 6, 12 h [ 21 ]. For treatment groups, ban sha herbal infusion, sprite, and fresh orange juice obviously increased the level of AST, while green tea, honey chrysanthemum tea, jasmine tea, and soda water markedly decreased the level of AST in serum.…”

Section: Resultsmentioning

confidence: 99%

Effects of Beverages on Alcohol Metabolism: Potential Health Benefits and Harmful Impacts

Wang

Zhang

Zhou

et al. 2016

IJMS

View full text Add to dashboard Cite

Nonalcoholic beverages are usually consumed accompanying alcoholic drinks, and their effects on alcohol metabolism are unclear in vivo. In this study, the effects of 20 nonalcoholic beverages on alcohol metabolism and liver injury caused by alcohol were evaluated in mice. Kunming mice were orally fed with alcohol (52%, v/v) and beverages. The concentrations of ethanol and acetaldehyde in blood as well as the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in liver were assessed to indicate alcohol metabolism. The levels of aspartate aminotransferase (AST) and alanine transaminase (ALT) in serum as well as the levels of malonaldehyde (MDA) and superoxide dismutase (SOD) in liver were measured to reflect the alcohol-induced liver injury. The results showed that the treatment of soda water, green tea and honey chrysanthemum tea could accelerate ethanol metabolism and prevent liver injuries caused by alcohol when companied with excessive alcohol drinking. They might be potential dietary supplements for the alleviation of harmful effects from excessive alcohol consumption. On the contrary, some beverages such as fresh orange juice and red bull are not advised to drink when companied with alcohol consumption due to their adverse effects on ethanol induced liver injury.

show abstract

Section: Resultsmentioning

confidence: 99%

Effects of Beverages on Alcohol Metabolism: Potential Health Benefits and Harmful Impacts

Wang

Zhang

Zhou

et al. 2016

IJMS

View full text Add to dashboard Cite

show abstract

“…We measured blood ALT and AST concentration at 1, 3, and 5 h after EtOH administration. Usually, 6 h has been used for evaluation of ALT and AST levels [ 34 , 38 ]. In mice injected intraperitoneally with a single EtOH dose, ALT and AST were increased at 8 h and 12 h after administration, respectively [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models

et al. 2020

View full text Add to dashboard Cite

Accumulative alcohol hangovers cause liver damage through oxidative and inflammatory stress. Numerous antioxidant and anti-inflammatory reagents have been developed to reduce alcohol hangovers, but these reagents are still insignificant and have limitations in that they can cause liver toxicity. Oyster hydrolysate (OH), another reagent that has antioxidant and anti-inflammatory activity, is a product extracted through an enzymatic hydrolysis process from oysters (Crassostrea gigas), which can be easily eaten in meals. This study was aimed at determining the effects of OH on alcohol metabolism, using a single high dose of ethanol (EtOH) administered to rodents, by monitoring alcohol metabolic enzymes, oxidative stress signals, and inflammatory mediators. The effect of tyrosine-alanine (YA) peptide, a main component of OH, on EtOH metabolism was also identified. In vitro experiments showed that OH pretreatment inhibited EtOH-induced cell death, oxidative stress, and inflammation in liver cells and macrophages. In vivo experiments showed that OH and YA pre-administration increased alcohol dehydrogenase, aldehyde dehydrogenase, and catalase activity in EtOH binge treatment. In addition, OH pre-administration alleviated CYP2E1 activity, ROS production, apoptotic signals, and inflammatory mediators in liver tissues. These results showed that OH and YA enhanced EtOH metabolism and had a protective effect against acute alcohol liver damage. Our findings offer new insights into a single high dose of EtOH drinking and suggest that OH and YA could be used as potential marine functional foods to prevent acute alcohol-induced liver damage.

show abstract

“…In the alcoholic liver injury mouse model, the P. mume formula also exhibited hepatoprotective effects (Chen et al, 2016). Khan et al (2017) investigated the molecular mechanism using a metabolic approach.…”

Section: Liver Protectionmentioning

confidence: 99%

Comprehensive Review of Phytochemical Constituents, Pharmacological Properties, and Clinical Applications of Prunus mume

Gong

Tang

Song³

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Prunus mume is one of the most ancient medicinal herbs and health foods commonly used in Asian countries. It is widely used as a constituent of many medicinal preparations and as a food ingredient for its beneficial health effects. In this review, we retrieved reports from PubMed, embase, Scopus, and SciFinder databases, to collect extensive scientific evidence on the phytochemical constituents, pharmacological properties, and clinical applications of Prunus mume. The literature review revealed that approximately 192 compounds have been isolated from different parts of the plant, and their molecular structures have been identified. The pharmacological properties of the plant, including anti-diabetic, liver-protective, antitumor, antimicrobial, antioxidant, and anti-inflammatory activities, as well as their underlying mechanisms, have been clarified by in vitro and in vivo studies. Clinical studies, although very limited, have been highlighted in this review to provide a reference for further exploration on therapeutic applications of the plant.

show abstract

The Protective Effects of Buzui on Acute Alcoholism in Mice

Cited by 10 publications

References 15 publications

Effects of Beverages on Alcohol Metabolism: Potential Health Benefits and Harmful Impacts

Effects of Beverages on Alcohol Metabolism: Potential Health Benefits and Harmful Impacts

Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models

Comprehensive Review of Phytochemical Constituents, Pharmacological Properties, and Clinical Applications of Prunus mume

Contact Info

Product

Resources

About