The protective role of honey against cytotoxicity of cadmium chloride in mice

Cadmium (Cd) is a heavy metal belonging to the group of the main chemical pollutants of the natural and occupational environment in economically developed countries. The forecasts indicate that contamination of the environment with this toxic metal, and thus the exposure of the general population, will increase. Food (particularly plant products) is the main source of the general population exposure to this element. Moreover, an important, and often the main, source of intoxication with Cd is habitual tobacco smoking. Recent epidemiological studies have provided numerous evidence that even low-level environmental exposure to this toxic metal, nowadays occurring in numerous economically developed countries, creates a risk for health of the general population. The low-level lifetime exposure to this metal may lead to the damage to the kidneys, liver, skeletal system, and cardiovascular system, as well as to the deterioration of the sight and hearing. Moreover, it has been suggested that environmental exposure to this xenobiotic may contribute to the development of cancer of the lung, breast, prostate, pancreas, urinary bladder, and nasopharynx. Taking the above into account, the aim of this review article is to draw more attention to Cd as an environmental risk factor for the health of the general population and the need to undertake preventive actions allowing to reduce the risk of health damage due to a lifetime exposure to this toxic metal.

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Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies

Mężyńska

Brzóska

2017

Environ Sci Pollut Res

240

129

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Honey Can Obviate Heavy Metal Toxicity: A Review

Bhattacharya

2023

J Environ Pathol Toxicol Oncol

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Toxicity caused by heavy metals inflicts a grave global menace to the habitat and inhabitants. Arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) are the non-essential yet harmful heavy metals commonly associated with pollution and resultant health complications. Typical chelating/complexing agents are not worthy of combating heavy metal-induced sub-chronic and chronic toxicities. It transpires from scientific data mining that, honey obviates investigational heavy metal toxicity. This review aims to collate such investigations conducted against As, Cd, and Pb toxicity. There is a total of 19 pre-clinical works demonstrating the ameliorative effect of honey against empirical As, Cd, and Pb toxicity. Pre-clinical reports against Hg and clinical study against these heavy metals could not found. From the outcome of the current literature investigation, it seems that honey has a marked heavy metal toxicity meliorative effect which is chiefly ascribed to its innate antioxidant effect due to its diverse polyphenol content.

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Review of Antioxidant-rich Natural Dietary Products as Protective and Therapeutic Factors against Cadmium Toxicity in Living Organisms

Quddus¹,

Yimer²,

Basit³

et al. 2021

JTAS

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Advances in civilization processes and industrialization have doubled the release of toxic heavy metals into the environment, consequently elevating their presence in the food chains. Cadmium (Cd) is one of the severe toxic metals widely present in the atmosphere. The major route of animal or human exposure to Cd is through water or food ingestion and inhalation of particles or inhalation of fumes during various industrial processes. Continuous exposure to low levels of Cd results in a gradual deposition in different tissues of the body, causing toxic effects on the liver, kidneys, testes, and other vital organs. The beneficial effect of natural antioxidants against chemical induced toxicity is receiving more attention. Antioxidant-rich dietary products and their function in tempering free radicals produced in the body under different pathological conditions is an active research field. In the current review, we attempted to highlight the current research progress in the field of using antioxidant-rich natural dietary products and their function in mitigating or preventing health issues and tissue damage associated with Cd induced toxicity along with its mechanism.

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The protective role of honey against cytotoxicity of cadmium chloride in mice

Cited by 3 publications

References 43 publications

Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies

Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies

Honey Can Obviate Heavy Metal Toxicity: A Review

Review of Antioxidant-rich Natural Dietary Products as Protective and Therapeutic Factors against Cadmium Toxicity in Living Organisms

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