The protoapigenone analog WYC0209 targets CD133+ cells: A potential adjuvant agent against cancer stem cells in urothelial cancer therapy

Yeh, Bi-Wen; Yu, Liang; Li, Ching Chia; Yang, Juan; Li, Wei Ming; Wu, Yang Chang; Wei, Yu; Lee, Hsueh Te; Kung, Mei-Lang; Wu, Wen Jeng

doi:10.1016/j.taap.2020.115129

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…In the urothelium, the transition from basal to terminally differentiated superficial cells is reflected in the different protein synthesis for each layer, which leads to the various morphological and antigenic characteristics [11,16]. CD44 is a cell adhesion molecule involved in tumor growth and biological behavior.…”

Section: Discussionmentioning

confidence: 99%

Expression of Basal Compartment and Superficial Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy, a Worldwide Disease

Jankovic Velickovic,

Ristic Petrovic,

Dolicanin

et al. 2024

Biomedicines

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The aim of this study was to determine the association of basal compartment and superficial markers, comprising CK5/6, CD44, CK20, and the pathological characteristics of upper tract urothelial carcinoma (UTUC) associated with Balkan endemic nephropathy (BEN). Comparing the expression of the investigated markers in 54 tumors from the BEN region and 73 control UTUC, no significant difference between them was detected. In regression analysis, CK20 expression was not determined with expression of CK5/6, CD44, and the phenotypic characteristics of BEN and control UTUC. Parameters with predictive influence on the expression of CD44 in BEN UTUC included growth pattern (p = 0.010), necrosis (p = 0.019); differentiation (p = 0.001), and lymphovascular invasion (p = 0.021) in control UTUC. Divergent squamous differentiation in BEN tumors (p = 0.026) and stage in control tumors (p = 0.049) had a predictive influence on the expression of CK5/6. This investigation detected a predictive influence of the phenotypic characteristics of UTUC on the expression of basal compartment and superficial markers, with a significant influence of necrosis in BEN tumors (p = 0.006) and differentiation in control UTUC (p = 0.036).

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Section: Discussionmentioning

confidence: 99%

Expression of Basal Compartment and Superficial Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy, a Worldwide Disease

Jankovic Velickovic,

Ristic Petrovic,

Dolicanin

et al. 2024

Biomedicines

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“…Moreover, the flavonoid derivative WYC0209 is a potential adjuvant agent against CD133-driven urothelial carcinoma (UC) CSCs and could serve as a potent strategy against UC therapeutic resistance; among others, WYC0209 declined EMT-CSCs markers such as MDR-1 or ABCG2 in vitro [ 138 ].…”

Section: Resistance To Anti-cancer Treatmentsmentioning

confidence: 99%

Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles

et al. 2021

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Cost-efficacy of currently applied treatments is an issue in overall cancer management challenging healthcare and causing tremendous economic burden to societies around the world. Consequently, complex treatment models presenting concepts of predictive diagnostics followed by targeted prevention and treatments tailored to the personal patient profiles earn global appreciation as benefiting the patient, healthcare economy, and the society at large. In this context, application of flavonoids as a spectrum of compounds and their nano-technologically created derivatives is extensively under consideration, due to their multi-faceted anti-cancer effects applicable to the overall cost-effective cancer management, primary, secondary, and even tertiary prevention. This article analyzes most recently updated data focused on the potent capacity of flavonoids to promote anti-cancer therapeutic effects and interprets all the collected research achievements in the frame-work of predictive, preventive, and personalized (3P) medicine. Main pillars considered are:- Predictable anti-neoplastic, immune-modulating, drug-sensitizing effects;- Targeted molecular pathways to improve therapeutic outcomes by increasing sensitivity of cancer cells and reversing their resistance towards currently applied therapeutic modalities.

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Exosome-based nanomedicine for cancer treatment by targeting inflammatory pathways: Current status and future perspectives

Ansari

Thiruvengadam

Venkidasamy³

et al. 2022

Seminars in Cancer Biology

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The protoapigenone analog WYC0209 targets CD133+ cells: A potential adjuvant agent against cancer stem cells in urothelial cancer therapy

Cited by 4 publications

References 52 publications

Expression of Basal Compartment and Superficial Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy, a Worldwide Disease

Expression of Basal Compartment and Superficial Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy, a Worldwide Disease

Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles

Exosome-based nanomedicine for cancer treatment by targeting inflammatory pathways: Current status and future perspectives

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