The pseudomembranous colitis associated with clindamycin therapy--a viral colitis.

Steer, H W

doi:10.1136/gut.16.9.695

Cited by 36 publications

(20 citation statements)

References 21 publications

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“…Minocycline has also been associated with serum sickness-like reactions, drug-induced lupus, and hypersensitivity reactions (66 Clindamycin has been shown to have a similar efficacy as tetracycline in the treatment of inflammatory acne (69). However, its use has been associated with pseudomembranous colitis, affecting between two and 30% of patients (70). Because of this important side effect, clindamycin is rarely used as an acne treatment (9).…”

Section: 62t1 Tetracycune Minocycline and Doxycycljnementioning

confidence: 99%

Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris

Azoulay¹,

Blais²,

Koren³

et al. 2008

J. Clin. Psychiatry

129

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Section: 62t1 Tetracycune Minocycline and Doxycycljnementioning

confidence: 99%

Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris

Azoulay¹,

Blais²,

Koren³

et al. 2008

J. Clin. Psychiatry

129

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“…Published concepts concerning the cause of antibiotic-associated diarrhea and pseudomembranous colitis ranged from a direct effect of the antibiotic or a metabolite of the antibiotic on the intestinal mucosa (213) to changes in the intestinal microflora or a localized Schwartzmann reaction (125,221). In several studies, viruslike particles were visualized by electron microscopy of intestinal biopsy samples from patients with pseudomembranous colitis (111,165,253). However, viruses have never been propagated from patients with the disease.…”

Section: Introductionmentioning

confidence: 99%

Clostridium difficile: clinical disease and diagnosis

1993

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Clostridium difficile is an opportunistic pathogen that causes a spectrum of disease ranging from antibiotic-associated diarrhea to pseudomembranous colitis. Although the disease was first described in 1893, the etiologic agent was not isolated and identified until 1978. Since clinical and pathological features of C. difficile-associated disease are not easily distinguished from those of other gastrointestinal diseases, including ulcerative colitis, chronic inflammatory bowel disease, and Crohn's disease, diagnostic methods have relied on either isolation and identification of the microorganism or direct detection of bacterial antigens or toxins in stool specimens. The current review focuses on the sensitivity, specificity, and practical use of several diagnostic tests, including methods for culture of the etiologic agent, cellular cytotoxicity assays, latex agglutination tests, enzyme immunoassay systems, counterimmunoelectrophoresis, fluorescent-antibody assays, and polymerase chain reactions.

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“…The aetiology is probably multifactorial but in cases associated with broad-spectrum antibiotics an alteration in bowel flora may be responsible. Steer (1975) has recently demonstrated virus particles in colonic mucosal cells and in the pseudomembrane in four patients with clindamycinassociated colitis. He suggests that alteration of the normal colonic bacterial flora makes the colonic mucosa more susceptible to viral infection.…”

Section: Discussionmentioning

confidence: 99%