The psoriasiform reaction pattern

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00005-x

Cited by 17 publications

(52 citation statements)

References 777 publications

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“…[3] Often, it is associated with collections of neutrophils and/or plasma, called “scale crust.” Mounds of parakeratosis can be present throughout the epidermis in conditions like psoriasis and dermatophytosis, confined to the infundibular ostia (Seborrheic dermatitis) or seen in both locations, like in pityriasis rubra pilaris (PRP). [123] The classic “checkerboard” pattern of PRP i.e., parakeratosis staggered in both vertical and horizontal fronts is often difficult to find, even on multiple sections [Figure 1a]. [1] Confluent parakeratosis is seen in dermatophytosis, syphilis, pityriasis lichenoides chronica and most importantly, in mycosis fungoides (MF).…”

Section: Changes In Stratum Corneummentioning

confidence: 99%

“…[123] The classic “checkerboard” pattern of PRP i.e., parakeratosis staggered in both vertical and horizontal fronts is often difficult to find, even on multiple sections [Figure 1a]. [1] Confluent parakeratosis is seen in dermatophytosis, syphilis, pityriasis lichenoides chronica and most importantly, in mycosis fungoides (MF). Sharply defined, thick zones of parakeratosis alternating with orthokeratosis and mild papillomatosis is a feature of inflammatory linear epidermal nevus (ILVEN).…”

Section: Changes In Stratum Corneummentioning

confidence: 99%

“…Many textbooks give detailed descriptions about individual diseases and this review does not attempt to replicate them. [12] This article outlines the microscopic approach and emphasizes certain important principles and clues that should always be at the back of one's mind when evaluating these cases.…”

Section: Introductionmentioning

confidence: 99%

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Psoriasiform dermatoses: Microscopic approach

Tirumalae

2013

Indian J Dermatol

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Section: Changes In Stratum Corneummentioning

confidence: 99%

Section: Changes In Stratum Corneummentioning

confidence: 99%

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Psoriasiform dermatoses: Microscopic approach

Tirumalae

2013

Indian J Dermatol

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“…15,17,18,23,27 The re fo re ul tra vi o let ra di a ti on type B (UVB)-in du ced apopto sis can be me di a ted by eit her the Fas or the p53 path ways. 24 In duc ti on of apo p to sis in epi der mal kera ti nocy tes ap pe ars to be the mec ha nism res ponsib le for the in vo lu ti on of the pso ri a tic hyperp la si a that fol lows PU VA. 5 Our study rep ro du ced the li te ra tu re da ta abo ut the cytop las mic and nuc le ar re ac ti vity in ba sal ke rati nocy tes and ex pres si on of cytop las mic pro te in thro ug ho ut the epi der mis in pso ri a sis with p53 prote in. A co up le of stu di es disc lo sed an in cre a se in cellu lar pro li fe ra ti on in pso ri a tic le si ons using p53 pro te in ex pres si on.…”

mentioning

confidence: 99%

“…It is pos sib le that dif fe rent eti o logi c factors may ini ti a te pso ri a sis in ge ne ti cally sus cep tib le in di vi du als. 5,8,9 Di sor ders of ke ra tinocy te pro li fe ra ti on, dif fe ren ti a ti on, inf lam ma tion and im mu ne dysre gu la ti on are the ma jor fac tors imp li ca ted in the pat ho ge ne sis of pso ri a sis vul ga ris. [1][2][3][4][5]8 T-cell clo nes obtained from pso ri a tic skin le sions had the se lec ti ve ca pa city of en han cing the pro li fe ra ti on of ke ra ti nocy tes in vit ro.…”

mentioning

confidence: 99%

Mast Cells and p53 Expression in Psoriasis Vulgaris

Barut¹,

Bektaş²,

Gün³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Pso ri a sis vul ga ris is a chro nic inf lam ma tory T-cell me di a ted im mu ne derma to sis cha rac te ri zed by a high epi der mal cell tur no ver, which re sults in a typi cal epi der mal hyperp la si a. The aim of this study is to show the cor re la ti on bet we en p53 pro te in ac cu mu la ti on that pro vi des epi der mal hyper pro li fe ra ti on and mast cell co unt in the pat ho ge ne sis of pso ri a sis vul garis. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In this study, punch bi op si es from 56 pso ri a sis ca ses ha ve be en eva lua ted. The pre sen ce of mast cells in with me tac hro ma tic gra nu les are with 1% to lu i din blu e sta in so lu ti on has be en in ves ti ga ted. In ad di ti on, mast cells that show im mu no re ac ti ons to "mast cell trypta se " an ti body ha ve be en ob ser ved and pro por ti on of p53 sta i ning in epi der mal ke ra ti nocy tes has be en de ter mi ned. R Re e s su ul lt ts s: : In pso ri a sis ca ses, mast cells co unt (me an) and pro por ti on of p53 stai ning (me an) were 69.3 ± 21.5/mm 2 and 602.3 ± 192.1 respectively, in the gro up wit ho ut any treat ment (n: 20); 57.1 ± 27.5/mm 2 and 373.1 ± 193.6 respectively in the gro up tre a ted with pso la ren plus UVA ra di a ti on (n: 36). In the con trol gro up, it was de mons tra ted that mast cells co unt was 74.6 ± 25.9/mm 2 (me an) and pro por ti on of p53 sta i ning was 176.4 ± 109.2 (me an). No cor re la ti on has be en fo und bet we en mast cell co unt and pro por ti on of p53 sta i ning in pso ri a sis gro ups. Ho we ver, a mo de ra te cor re la ti on (r= 0.30 P< 0.05) has be en fo und bet we en mast cell co unt and pro por ti on of p53 sta i ning in the con trol gro up. C Co on nc c l lu u s si i o on n: : Sin ce the cor re la ti on ob ta i ned bet we en mast cell num ber and pro por ti on of p53 sta i ning in the he althy skin was not observed pso ri a sis ca ses, it can be tho ught that the se va ri ab les ta ke part in different pathways of pathogenesis.K Ke ey y W Wo or rd ds s: : Pso ri a sis; mast cells; p53 pro te in (325-355) Ö ÖZ ZE ET T A Am ma aç ç: : Pso ri a zis vul ga ris, yük sek epi der mal hüc re yı kı mı ile ka rak te ri ze, ti pik epi der mal hiperp la zi ile so nuç la nan kro nik inf la ma tu ar T hüc re ba ğım lı bir der ma toz dur. Bu ça lış ma nın ama cı, pso ri a zis vul ga ris pa to ge ne zin de yer alan mast hüc re sa yı sı ile epi der mal hi per pro li fe ras yo nu sağ -la yan p53 pro te in bi ri ki mi ara sın da ki ko re las yo nu gös ter mek tir. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu ça lış mada 56 pso ri a zis vul ga ris va ka sı na ait punch bi yop si ma ter ya li de ğer len di ril miş tir. Yüzde birlik to lu i din ma vi si ile bo ya nan me tak ro ma tik gra nül ler içe ren mast hüc re le rin var lı ğı araş tı rıl mış tır. İla ve ola rak, mast hüc re trip taz an ti ko ru ile re ak si yon ve ren mast hüc re le ri in ce len miş ve epi dermal ke ra ti no sit ler de ki p53 bo yan...

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Eosinophils Among the Histological Features of Psoriasis

Penn

Brinster²

2019

The American Journal of Dermatopathology

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Eosinophils are absent in psoriasis" has been dogma for generations; yet, there is little published to support this statement. Two recent studies examining the presence of eosinophils in psoriasis came to contrasting conclusions. We reviewed skin biopsies from 50 patients with clinically confirmed cases of psoriasis vulgaris to characterize the histologic features, with a focus on the number of eosinophils in the dermis. We noted the presence of eosinophils in nearly half of our study population (n = 23, 46.0%). There was no significant association between the presence of eosinophils and degree of spongiosis (P = 0.405). Eosinophil density ranged from 0 to 8 per tissue section. The mean average eosinophil density was 1.04 (range: 0-8) per tissue section. Among cases with eosinophils, there were 73.9% (n = 17/23) of cases with 1-2 eosinophils, and 26.1% (n = 6) with 3-8 eosinophils. Mild to moderate spongiosis was noted in the majority of cases (n = 48; 96.0%). Eosinophils were only present in psoriasis cases with evidence of spongiosis (n = 23; 47.9%). We conclude that eosinophils are not an uncommon finding in the dermis of psoriasis vulgaris, although the number is often few. The presence of eosinophils should not preclude a diagnosis of psoriasis, particularly if other histologic features are supportive.

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The psoriasiform reaction pattern

Cited by 17 publications

References 777 publications

Psoriasiform dermatoses: Microscopic approach

Psoriasiform dermatoses: Microscopic approach

Mast Cells and p53 Expression in Psoriasis Vulgaris

Eosinophils Among the Histological Features of Psoriasis

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