The psychosocial context of chronic pain in people living with HIV

Scott, Whitney

doi:10.1097/pr9.0000000000000721

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Other components of the HIV virus may also be involved in addition to gp120, including viral Transactivator of Transcription (Tat) (Wodarski et al, 2018). The biological mechanisms underlying pain in HIV neuropathy have been poorly elucidated, but various psychosocial factors have been identified (Scott et al, 2018;Scott, 2019).…”

Section: Introductionmentioning

confidence: 99%

Peripheral Nerve Imaging

2022

Frontiers Research Topics

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Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers Journal SeriesThe Frontiers Journal Series is a multi-tier and interdisciplinary set of open-access, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers Journal Series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to QualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation.

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Section: Introductionmentioning

confidence: 99%

Peripheral Nerve Imaging

2022

Frontiers Research Topics

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“…Other components of the HIV virus may also be involved in addition to gp120, including viral Transactivator of Transcription (Tat) (Wodarski et al, 2018 ). The biological mechanisms underlying pain in HIV neuropathy have been poorly elucidated, but various psychosocial factors have been identified (Scott et al, 2018 ; Scott, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging as a Biomarker in Diabetic and HIV-Associated Peripheral Neuropathy: A Systematic Review-Based Narrative

et al. 2021

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Background: Peripheral neuropathy can be caused by diabetes mellitus and HIV infection, and often leaves patients with treatment-resistant neuropathic pain. To better treat this condition, we need greater understanding of the pathogenesis, as well as objective biomarkers to predict treatment response. Magnetic resonance imaging (MRI) has a firm place as a biomarker for diseases of the central nervous system (CNS), but until recently has had little role for disease of the peripheral nervous system.Objectives: To review the current state-of-the-art of peripheral nerve MRI in diabetic and HIV symmetrical polyneuropathy. We used systematic literature search methods to identify all studies currently published, using this as a basis for a narrative review to discuss major findings in the literature. We also assessed risk of bias, as well as technical aspects of MRI and statistical analysis.Methods: Protocol was pre-registered on NIHR PROSPERO database. MEDLINE, Web of Science and EMBASE databases were searched from 1946 to 15th August 2020 for all studies investigating either diabetic or HIV neuropathy and MRI, focusing exclusively on studies investigating symmetrical polyneuropathy. The NIH quality assessment tool for observational and cross-sectional cohort studies was used for risk of bias assessment.Results: The search resulted in 18 papers eligible for review, 18 for diabetic neuropathy and 0 for HIV neuropathy. Risk of bias assessment demonstrated that studies generally lacked explicit sample size justifications, and some may be underpowered. Whilst most studies made efforts to balance groups for confounding variables (age, gender, BMI, disease duration), there was lack of consistency between studies. Overall, the literature provides convincing evidence that DPN is associated with larger nerve cross sectional area, T2-weighted hyperintense and hypointense lesions, evidence of nerve oedema on Dixon imaging, decreased fractional anisotropy and increased apparent diffusion coefficient compared with controls. Analysis to date is largely restricted to the sciatic nerve or its branches.Conclusions: There is emerging evidence that various structural MR metrics may be useful as biomarkers in diabetic polyneuropathy, and areas for future direction are discussed. Expanding this technique to other forms of peripheral neuropathy, including HIV neuropathy, would be of value.Systematic Review Registration: (identifier: CRD 42020167322) https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=167322.

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“…Despite this, there has been a to be as high as 85% [6][7][8][9]. The etiology of chronic pain for PWH is multifactorial resulting from HIVrelated causes (virally-mediated nerve damage, chronic inflammation, side effects from antiretroviral therapy (ART)), psychological exacerbators (depression, anxiety, post-traumatic stress disorder), and other factors such as socioeconomic stressors or musculoskeletal injuries [10][11][12][13][14]. Among PWH, chronic pain has been associated with psychological and functional morbidity, decreased use of ART, and reduced retention in HIV primary care [15,16].…”

Section: Introductionmentioning

confidence: 99%

From Silos to Solidarity: Case Study of a Patient-Centered, Integrative Approach to Opioid Tapering and Chronic Pain Mitigation in a Multidisciplinary AIDS Clinic

et al. 2021

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concurrent 25% increase in reports of adults with chronic pain over the last two decades, indicating that increased opioid use does not correlate with decreased pain [5]. In fact, the use of opioids for chronic pain-while pervasive remains controversial, as there are not data to support the effectiveness of opioids in the mitigation of non-malignant chronic pain [4,5].Compared to the estimated 8-20% of the general US population that reported chronic pain, the prevalence of chronic pain in people with HIV (PWH) is estimated

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The psychosocial context of chronic pain in people living with HIV

Cited by 7 publications

References 31 publications

Peripheral Nerve Imaging

Peripheral Nerve Imaging

Magnetic Resonance Imaging as a Biomarker in Diabetic and HIV-Associated Peripheral Neuropathy: A Systematic Review-Based Narrative

From Silos to Solidarity: Case Study of a Patient-Centered, Integrative Approach to Opioid Tapering and Chronic Pain Mitigation in a Multidisciplinary AIDS Clinic

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