The PTX family of homeodomain transcription factors during pituitary developments

Drouin, Jacques; Lamolet, Bruno; Lamonerie, Thomas; Lanctôt, Christian; Tremblay, Jacques

doi:10.1016/s0303-7207(98)00026-4

Cited by 108 publications

(58 citation statements)

References 15 publications

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“…One interesting possibility is that of relationships between these specific cell-to-cell affinities and ontogeny of these cells. However, we could find no such relationships between our findings and a report by Drouin et al [6], in which they studied development of pituitary cells by analyzing homeodomain transcription factors. This might suggest that the hormone-producing cells in the gland migrate after the differentiation.…”

Section: Discussioncontrasting

confidence: 92%

Topographic Affinities of Hormone-Producing Cells in the Rat Anterior Pituitary Gland.

Noda

Kaidzu

Kikuchi

et al. 2001

Acta Histochem. Cytochem

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We examined the topographic cell affinity of different types of hormone-producing cells in the rat anterior pituitary gland. Pituitaries were removed from 8-10 week-old male SD rats, and were fixed in sublimate-formalin. The 40 mm sections were obtained with a Microslicer, then double-immunolabeled (FITC and TexasRed methods) using antibodies against five types of pituitary hormones. Topographic affinity was examined threedimensionally using a confocal microscope, and was expressed as attachment rate. Statistical analysis revealed that the different types of hormoneproducing cells did not exist at random locations in the gland, but rather showed specific topographic affinities. The following pairs of cell types were observed to have significantly high affinities: LH and PRL cells, ACTH and GH cells, and TSH and GH cells. In contrast, the following pairs of cell types were observed to have no significant affinities: GH and PRL cells, ACTH and LH cells, TSH and LH cells, ACTH and TSH cells, and cells of the same type. These specific topographic affinities between different types of anterior pituitary cells may be intimately related to cell-to-cell interactions in the gland.

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Section: Discussioncontrasting

confidence: 92%

Topographic Affinities of Hormone-Producing Cells in the Rat Anterior Pituitary Gland.

Noda

Kaidzu

Kikuchi

et al. 2001

Acta Histochem. Cytochem

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“…Vertebrate Pitx1 is an early marker of the stomodeum and the foregut endoderm, and its expression persists in the olfactory and adenohypophyseal epithelia into late development (Lanctot et al, 1997). In the pituitary, Pitx1 ultimately acts to regulate transcription of hormone genes, and Pitx2 is important for proper morphogenesis of Rathke's pouch (Drouin et al, 1998;Suh et al, 2002). Larvacean pitx is also expressed in the mouth and rostral foregut, where it overlaps with the expression of six3/6a and six3/6b.…”

Section: The Ciliary Funnel and The Vertebrate Pituitarymentioning

confidence: 99%

The evolutionary history of placodes: a molecular genetic investigation of the larvacean urochordate Oikopleura dioica

Bassham

Postlethwait

2005

Development

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The evolutionary origin of vertebrate placodes remains controversial because divergent morphologies in urochordates, cephalochordates and vertebrates make it difficult to recognize organs that are clearly homologous to placode-derived features, including the olfactory organ, adenohypophysis, lens, inner ear, lateral line and cranial ganglia. The larvacean urochordate Oikopleura dioica possesses organs that morphologically resemble the vertebrate olfactory organ and adenohypophysis. We tested the hypothesis that orthologs of these vertebrate placodes exist in a larvacean urochordate by analyzing the developmental expression of larvacean homologs of the placode-marking gene families Eya, Pitx and Six. We conclude that extant chordates inherited olfactory and adenohypophyseal placodes from their last common ancestor, but additional independent proliferation and perhaps loss of placode types probably occurred among the three subphyla of Chordata.

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“…In this case, however, the elements consist of those that bind early growth response 1 (Egr1) (11)(12)(13)(14)(15)(16), steroidogenic factor 1 (SF-1) (11)(12)(13)(14)(15)(16)(17)(18)(19)(20), Pitx1 (21)(22)(23), and an as yet unidentified Otx-related homeodomain protein (24), as well as proteins that bind elements in the distal domain, such as nuclear factor-Y (NF-Y) and Sp1 (16,(25)(26)(27). Unlike ␣GSU, which is a marker of early pituitary development, expression of the LH␤ gene is one of the last steps that defines a mature gonadotrope.…”

mentioning

confidence: 99%

Embryonic Expression of the Luteinizing Hormone β Gene Appears to Be Coupled to the Transient Appearance of p8, a High Mobility Group-related Transcription Factor

Quirk

Seachrist

Nilson

2003

Journal of Biological Chemistry

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A comparison between two pituitary-derived cell lines (␣T3-1 and L␤T2) that represent gonadotropes at early and late stages of development, respectively, was performed to further elucidate the genomic repertoire required for gonadotrope specification and luteinizing hormone ␤ (LH␤) gene expression. One isolated clone that displayed higher expression levels in L␤T2 cells encodes p8, a high mobility group-like protein with mitogenic potential that is up-regulated in response to proapoptotic stimuli and in some developing tissues. To test the functional significance of this factor in developing gonadotropes, a knockdown of p8 in L␤T2 cells was generated. The loss of p8 mRNA correlated with loss of endogenous LH␤ mRNA and the loss of activity of a transfected LH␤ promoter-driven reporter, even upon treatment with gonadotropin-releasing hormone. In addition, expression of p8 mRNA in developing mouse pituitary glands mirrored its expression in the gonadotrope-derived cell lines and coincided with the first detectable appearance of LH␤ mRNA. In contrast, p8 mRNA was undetectable in the pituitary glands of normal adults. Taken together, our data indicate that p8 is a stage-specific component of the gonadotrope transcriptome that may play a functional role in the initiation of LH␤ gene expression during embryonic cellular differentiation.With its ability to stimulate gonadal steroidogenesis and gametogenesis, luteinizing hormone (LH) 1 is essential for normal reproductive function in mammals (1, 2). Luteinizing hormone is a heterodimeric protein composed of an ␣ glycoprotein hormone subunit (␣GSU) common to all members of the glycoprotein family of hormones that is non-covalently linked to a unique LH␤ subunit that confers its biological specificity (1, 2). Biosynthesis of LH depends on the coordinated expression of both the ␣GSU and LH␤ subunit genes. In humans, the single copy ␣GSU gene resides on chromosome 6q12-q21 (Locus ID 1081) while the LH␤ gene resides amid a cluster of six chorionic gonadotropin-␤ genes on chromosome 19q13.32 (Locus ID 1082). In addition to their different locations within the human genome, the pattern of expression of the genes encoding ␣GSU and LH␤ are temporally and spatially distinct.During development ␣GSU is seen throughout Rathke's pouch as early as embryonic day (e) 9.5 in the mouse (3). By later stages of pituitary development and in adult mammals, ␣GSU expression is limited to thyrotropes and gonadotropes (4). Gonadotrope-specific expression of the ␣GSU gene is controlled by an array of regulatory elements, including the pituitary glycoprotein hormone basal element (5, 6), ␣ basal elements (6), gonadotrope-specific element (7), and tandemly repeated cAMP response elements (8 -10), as well as the intricate interplay between their cognate binding proteins (6).In a fashion similar to the ␣GSU promoter, the LH␤ gene is regulated by a combinatorial array of transcription factors and regulatory elements. In this case, however, the elements consist of those that bind early growth response ...

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The PTX family of homeodomain transcription factors during pituitary developments

Cited by 108 publications

References 15 publications

Topographic Affinities of Hormone-Producing Cells in the Rat Anterior Pituitary Gland.

Topographic Affinities of Hormone-Producing Cells in the Rat Anterior Pituitary Gland.

The evolutionary history of placodes: a molecular genetic investigation of the larvacean urochordate Oikopleura dioica

Embryonic Expression of the Luteinizing Hormone β Gene Appears to Be Coupled to the Transient Appearance of p8, a High Mobility Group-related Transcription Factor

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