The pubertal development mode of Chinese girls with turner syndrome undergoing hormone replacement therapy

Guo, Song; Zhang, Mengjie; Li, Yanhong; Ma, Haitian; Chen, Qiuli; Chen, Hongshan; Du, Mingmei

doi:10.1186/s12902-019-0403-2

Cited by 2 publications

(1 citation statement)

References 20 publications

(24 reference statements)

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“…About one-third of girls with TS have spontaneous menstruation, usually in patients with a mosaic karyotype ( 22 ). Most patients with TS will need HRT to induce puberty and for maintaining female secondary sex characteristics, attaining peak bone mass and normalizing uterine growth ( 1 , 23 ). Studies have shown that having pubertal development at the right age has a positive effect on the psychological well-being of girls with TS ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Psychosomatic Mutual Aid Treatment on Anxiety and Depression in Turner Syndrome

Lin

Lash

et al. 2021

Front. Psychiatry

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Background: Turner syndrome (TS) affects approximately one out of 2,500 females. Previous research indicates that girls with TS experience psychosocial impairment in addition to their physical health issues. However, there is no current data demonstrating whether reducing the clinical symptoms of girls or women with TS through hormone replacement therapy (HRT) combined with psychological interventions, referred to as psychosomatic mutual aid treatment (PMAT), improves physical and psychological self-identification, so that psychological problems such as anxiety, depression, low self-esteem, social loneliness, and psychological resilience are improved. Therefore, the objective of this research was to assess the efficacy of PMAT on anxiety and depression in girls and women with TS.Methods: Twenty-six girls and women with TS aged 11–29 years (17.5 ± 4.2 years) were recruited. Anxiety and depression were assessed using Hamilton Anxiety Rating Scale (HAMA) and Zung Self-Rating Depression Scale (SDS) questionnaires, respectively. The 26 TS patients were surveyed for anxiety and depression before the beginning of PMAT and again in January 2020. In addition, 20 healthy volunteer women aged 16–39 years (23.1 ± 5.7 years) were selected as the control group and filled in the questionnaire.Results: Pre-therapy (pre-HRT and Pre-PMAT) there were significant differences between the TS patients (n = 26) and healthy controls (n = 20). In particular, the TS patients had higher anxiety status (P = 0.04) and severity (P = 0.03) (HAMA score), as well as depression status (P = 0.002) and severity (P < 0.001) (SDS score). Post-therapy there was no longer any difference in depression scores, but TS patients still had higher levels of anxiety post-therapy compared with healthy control women (psychic symptoms score, P = 0.03; anxiety status score, P = 0.04; anxiety severity score, P = 0.04). In the TS patients, there was an improvement in depression scores (SDS score P < 0.001; depression severity score, P = 0.005) after therapy but no change in levels of anxiety.Conclusions: PMAT significantly improves depression status, but not anxiety, in girls and women with TS.Clinical Trial Registration:http://www.chictr.org.cn/showproj.aspx?proj=124736, identifier: ChiCTR2100045230.

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Section: Discussionmentioning

confidence: 99%

Effects of Psychosomatic Mutual Aid Treatment on Anxiety and Depression in Turner Syndrome

Lin

Lash

et al. 2021

Front. Psychiatry

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Current Recommended Estrogen Dosing for Pubertal Induction in Turner Syndrome Results in Normal Uterine Growth

Lindsay Mart,

Gutmark-Little,

Streich-Tilles

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Most individuals with Turner syndrome (TS) require estrogen for pubertal induction. Current estrogen dosing guidelines are based on expert consensus opinion. Objective Evaluate whether current international guidelines for estrogen dosing during pubertal induction of individuals with TS result in normal uterine growth. We hypothesized that uterine size in individuals with TS who reached adult estrogen dosing is smaller than in mature females without TS. Methods Cross-sectional study of patients with TS at the Cincinnati Center for Pediatric and Adult Turner Syndrome Care. Twenty-nine individuals (age 15-26 years) with primary ovarian insufficiency who reached adult estrogen dosing (100 µg of transdermal or 2 mg of oral 17β-estradiol) were included. Comparison of uterine measurements with a published sample of 292 age-appropriate (age 15-20 years) controls without TS. Uterine length, volume, and fundal–cervical ratio (FCR) were measured. Clinical information (karyotype, Tanner staging for breast development, laboratory data) was extracted from an existing institutional patient registry. Results There was no evidence of compromise of the uterine size/configuration in the TS cohort compared with the controls; in fact, uterine length, mean 7.7 cm (±1.3) vs 7.2 cm (±1.0) (P = .03), and volume, mean 60.6 cm3 (±26.6) vs 50.5 cm3 (±20.5) (P = .02), were both larger in individuals with TS. Conclusion Current international guidelines for hormone replacement using 17β-estradiol in individuals with TS appear adequate to allow for normal uterine growth by the end of pubertal induction.

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The pubertal development mode of Chinese girls with turner syndrome undergoing hormone replacement therapy

Cited by 2 publications

References 20 publications

Effects of Psychosomatic Mutual Aid Treatment on Anxiety and Depression in Turner Syndrome

Effects of Psychosomatic Mutual Aid Treatment on Anxiety and Depression in Turner Syndrome

Current Recommended Estrogen Dosing for Pubertal Induction in Turner Syndrome Results in Normal Uterine Growth

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