The Pulmonary Circulation in Men Under 60 Years Old With Myocardial Infarction and Chronic Inflammatory Pulmonary Disease

Abstract

Relevance. Formation of pulmonary hypertension (PH) in myocardial infarction (MI) and chronic inflammatory pulmonary diseases (CIPD) remains poorly understood. Aim. To evaluate changes in pulmonary circulation indicators (PCI) in men under 60 years old (y.o) with CIPD that in acute and subacute MI periods to improve understanding of developmental options and prevention. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with CIPD - 142 patients; II - control, without it - 424 patients. A comparative assessment of PCI in the first 48 hours and the end of the subacute period of MI in these groups was performed. Results. In the first hours of MI, higher values of total pulmonary resistance (TPR) (I: 572.4 ± 276.0; II: 505.3 ± 286.6 (dyn×sec×cm-5)) were noted in the study group. When considering their dynamics at the end of the third week of MI, the mean pressure in the pulmonary artery decreased in both groups (I: 18.3%; p˂0.0001; II: 11.2%; p˂0.0001). TPR decreased in both groups (I: 36.1%; II: 24.4%) and heart rate also decreased (I: 11.0%; II: 5.3%; p˂0,0001 for all indicators). Conclusions. The study group is distinguished by more pronounced disorders of pulmonary circulation in the first hours of MI, which confirms the feasibility of their assessment and study of indicators of the severity of CIPD as additional markers of a negative prognosis of PH.