The Pulmonary Microbiome as a Risk Factor for Lung Cancer Development and Progression. Review

Abstract

Lung cancer, being one of the leading causes of mortality among cancer patients, is a global medical and social problem. The number of studies devoted to the etiology, molecular pathology and methods of early detection of lung neoplasms has been steadily increasing. Recently, the great efforts are made to search for alternative methods of diagnosis, therapy and prevention of neoplasms of the respiratory system. So the study of the influence of the quantitative and qualitative microbiome characteristics on the growth and tumor development has become increasingly relevant. This review is devoted to the association between the composition of the pulmonary microbiome and the development of malignant neoplasms of the lungs. We used the analysis of the available literature data to perform this review.