The question about the topical antibiotic therapy of acute rhinosinusitis

Krivopalov, A. A.; Ryazansev, S. V.; Еремин, С. А.; Zakharova, G. P.; Шабалин, В. В.; Шамкина, П. А.; Чернушевич, И. И.

doi:10.17116/otorino20198402150

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…В это понятие входит группа всех патологий воспалительной этиологии полости носа и околоносовых пазух. Данный термин получил широкое признание, так как доказано, что воспаление затрагивает не только слизистую оболочку полости носа, но и обязательно захватывает слизистые оболочки околоносовых пазух [5,6].…”

Section: оториноларингология/Otorhinolaryngologyunclassified

“…В результате многих исследований установлено, что лидерами в этиологии острого бактериального риносинусита являются Streptococcus pneumoniae, Haemophilus influenzae и Moraxella catarrhalis, которые встречаются у взрослого населения в 20-43%, 22-35% и 2-10% случаев соответственно [5].…”

Section: оториноларингология/Otorhinolaryngologyunclassified

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Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx

Овчинников¹,

Мирошниченко²,

Nikolaeva³

2020

Russian Medical Inquiry

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Inflammatory diseases of the nasal cavity and paranasal sinuses are identified as the leading cause of upper respiratory disorders. Nose breathing is of crucial importance to provide the entry for air to get into the respiratory system. In addition to oxygen saturation, nose breathing provides the exchange of air in the paranasal sinuses. This process is required to maintain normal microflora of the nasal cavity. In contrast, mouth breathing occurring during the inflammatory diseases of the nasal cavity is associated with discomfort and poor health-related quality of life and results in inflammation. Viral inflammatory disorders often exacerbate a patient’s condition and provoke bacterial inflammation. Recent widespread occurrence of antimicrobial resistance forced to change the paradigm in the treatment of inflammatory disorders and to refocus on time-proved topical therapies. Systemic antibiotics are now used only for strict indications. Other treatment options are widely applied. Thus, silver preparations characterized by antiseptic and bactericidal properties allow to avoid complications and to aid the recovery. They are the best choice of topical agents for treating acute rhinosinusitis. KEYWORDS: acute rhinitis, acute rhinosinusitis, acute respiratory viral infections, antibacterial drugs, topical treatment, argentum proteinate. FOR CITATION: Ovchinnikov A.Yu., Miroshnichenko N.A., Nikolaeva Yu.O. Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx. Russian Medical Inquiry. 2020;4(4):238–242. DOI: 10.32364/2587-6821-2020-4-4-238-242.

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Section: оториноларингология/Otorhinolaryngologyunclassified

Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx

Овчинников¹,

Мирошниченко²,

Nikolaeva³

2020

Russian Medical Inquiry

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Phage therapy in overcoming antibiotic resistance in chronic rhinosinusitis

Krivopalov,

Moroz,

Belicheva

et al. 2023

Vestn. otorinolaringol.

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Features of the use of topical preparations of framycetin sulfate in the treatment of rhinosinusitis

2021

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Introduction. Acute rhinosinusitis is one of the most common infectious diseases in the world. But despite their predominantly viral nature, the activation of their own microflora occurring during the disease, the addition of pathogenic and the associated risks of rhinogenic complications lead to the widespread use of antibacterial therapy for this pathology. Local antiseptics, such as framycetin sulfate in the form of nasal spray, play an important role in the multicomponent structure of rhinosinusitis therapy.The aim of the study was to evaluate the effect of an aerosol preparation of framycetin sulfate of domestic and imported production on the activity of the atrial fibrillation of the nasal cavity as topical antibacterial therapy in acute rhinosinusitis.Materials and methods. The study included 30 adult patients diagnosed with acute rhinosinusitis. The patients were randomized into 2 equal groups and received standard therapy for this disease, according to clinical recommendations. The differences in the groups concerned only topical antibacterial therapy. The 1st experimental group used a drug of domestic production, the 2nd group - a control group, used an imported framycetin spray.Results. Data were obtained not only comparing the clinical picture depending on the treatment, but also information about the effect of the drug on the activity of the atrial epithelium of the nasal cavity, the distribution of the substance in the nasal cavity, and even considered the structural differences of the vials that affect the distribution of the drug during injection. Conclusion. Topical antibacterial therapy with framycetin sulphate is an effective method in complex treatment of acute rhinosinusitis. Innovative technologies for the creation of an aerosol of framicetin solution allow to achieve stable dosage of the drug during use.

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The question about the topical antibiotic therapy of acute rhinosinusitis

Cited by 10 publications

References 7 publications

Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx

Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx

Phage therapy in overcoming antibiotic resistance in chronic rhinosinusitis

Features of the use of topical preparations of framycetin sulfate in the treatment of rhinosinusitis

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