The Radiobiological Basis for Tissue Reactions in the Oral Cavity Following Therapeutic X-Irradiation: A Review

Baker, Donald G.

doi:10.1001/archotol.1982.00790490023005

Cited by 91 publications

(52 citation statements)

References 21 publications

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“…Less severe mucositis is noted in programs with daily fractions lower than 200 cGy, however in accelerated radiotherapy programs mucositis peaks within 3 weeks.The effects of radiotherapy upon epithelial cells are further enhanced by connective tissue damage. 33 In immunocompetent hosts, radiotherapy-induced oral lesions usually heal within 3 weeks after cessation of radiotherapy. Mucositis caused by interstitial radioactive implants usually appears in 7 to 10 days and peaks after 2 weeks.…”

Section: Introductionmentioning

confidence: 99%

Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment

Köstler

Hejna

Wenzel

et al. 2001

CA: A Cancer Journal for Clinicians

294

252

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The incidence and severity of oral mucositis is influenced by the type of antineoplastic treatment administered and by patient-related factors. Severe courses of oral mucositis are observed during simultaneous radiochemotherapy, which Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and TreatmentWolfgang J. Köstler, MD; Michael Hejna, MD; Catharina Wenzel, MD; and Christoph C. Zielinski, MD 290 CA A Cancer Journal for Clinicians ABSTRACT Chemotherapy-and radiotherapy-induced oral mucositis represents a therapeutic challenge frequently encountered in cancer patients. This side effect causes significant morbidity and may delay the treatment plan, as well as increase therapeutic expenses.The pathogenesis of this debilitating side effect can be attributed to the direct mucosal toxicity of cytotoxic agents and ionizing radiation and to indirect mucosal damage caused by a concomitant inflammatory reaction exacerbated in the presence of neutropenia, and the emergence of bacterial, mycotic, and viral infections. affects virtually all patients with head and neck cancer who receive this therapeutic modality. 8 However, up to 40% of patients treated with conventional chemotherapy and the more than 70% of patients undergoing conditioning therapy for bone marrow transplantation also experience oral treatment-related complications. 9,10The pathogenesis of oral mucositis is not fully understood, yet it is thought to involve direct and indirect mechanisms. Direct mucosal injury by radiation and chemotherapy interfere with the average 5-to 14-day turnover time of the oral epithelium 11 and induce apoptosis. Indirect stomatotoxic effects that result from the release of inflammatory mediators, loss of protective salivary constituents, and therapyinduced neutropenia have been postulated to contribute to the development of oral mucositis and also promote the emergence of bacteria, fungi, and viruses on damaged mucosa.12 Although a linear relationship among the occurrence of oral mucositis, oral and systemic granulocyte counts, and a coincidence of resolution of mucositis with neutrophil recovery, has been demonstrated, 10,[13][14][15] significant mucositis can occur in the absence of myelotoxicity. 16,17 In addition, the prophylactic or therapeutic elimination of the pathogenic mucosal flora frequently observed in patients developing oral mucositis by various antiseptic and antimicrobial agents can at most alleviate the course of oral mucositis (see Antimicrobal Agents p. 302).Based upon these considerations, newer pathophysiologic concepts have emerged characterizing oral mucositis as having an initial inflammatory/vascular phase, an epithelial phase, a (pseudomembraneous) ulcerative/bacteriological phase and a healing phase.18 During the inflammatory phase, tissue injury induces release of free radicals, modified proteins and proinflammatory cytokines including interleukin-1β, prostaglandins and tumor necrosis factor-α (TNF-α) by epithelial, endothelial, and connective tissue cells. These ...

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Section: Introductionmentioning

confidence: 99%

Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment

Köstler

Hejna

Wenzel

et al. 2001

CA: A Cancer Journal for Clinicians

294

252

View full text Add to dashboard Cite

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“…Es un hueso compacto con un alto contenido mineral, lo cual le confiere gran capacidad de absorción de la radiación 12 . Mientras que el cóndilo y la rama mandibular son relativamente resistentes a la isquemia inducida por radiación, las regiones mandibulares cuya irrigación depende fundamentalmente de la arteria dentaria inferior (el cuerpo, la sínfisis y la parasínfi-sis) son zonas con gran riesgo de sufrirla 5 , tal es el caso de la paciente que se presenta.…”

Section: Discussionunclassified

“…Un cierre primario hermético resulta crucial para evitar infecciones postoperatorias y fístulas crónicas. Por ello, el uso de injertos libres microvascularizados con componente óseo y de partes blandas es muy apropiado 3,6,[12][13][14] .…”

Section: Discussionunclassified

Doble injerto microvascularizado de peroné para reconstrucción bilateral mandibular por osteorradionecrosis

Martín

Gallo

Pons

et al. 2010

Rev Esp Cirug Oral y Maxilofac

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“…17 The reactive OH and H ions that form water molecules are known to be initiators of radiation damage in organic material, particularly, in interprismatic enamel. 18 Hence, with the greater proportion of organic material in deciduous teeth, it is logical that radiation will have a greater effect in these teeth, especially because, as described above, radiation has little effect on hydroxyapatite. Although deciduous teeth have more organic matrix and lower mineral content than permanent teeth, radiation did not cause any significant difference (p = 0.194) in µTBS between enamel and compomer.…”

Section: Collagen Which Is Affected By Radiation Is Found At Much Lmentioning

confidence: 99%

Microtensile Bond Strength of Polyacid-modified Composite Resin to Irradiated Primary Molars

Keleş

Yılmaz²,

Sezen

2018

The Journal of Contemporary Dental Practice

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Aim: This study evaluated the influence of various doses of radiotherapy on the microtensile bond strength (µTBS) of compomer resin to dentin and enamel in primary molars. Materials and methods:Thirty-five intact primary molars were collected and divided into seven groups. Teeth were irradiated with doses from 10 to 60 Gy, except for the control group. Compomer restorations were performed, and enamelcompomer resin beams and dentin-compomer resin beams were tested at a crosshead speed of 1 mm/min.

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The Radiobiological Basis for Tissue Reactions in the Oral Cavity Following Therapeutic X-Irradiation: A Review

Cited by 91 publications

References 21 publications

Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment

Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment

Doble injerto microvascularizado de peroné para reconstrucción bilateral mandibular por osteorradionecrosis

Microtensile Bond Strength of Polyacid-modified Composite Resin to Irradiated Primary Molars

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