2003
DOI: 10.1079/bjn2003920
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The rat as a model for pigs: comparative values for the digestibility of NSP and other macronutrients

Abstract: The present investigation was undertaken to study whether conventional male Wistar rats could be used as a model for pigs with regard to total tract digestibilities of NSP and macronutrients and whether nebacitin-treated rats could be used as a model for small intestinal digestibility in pigs. Nineteen experimental diets prepared from different fractions of wheat and oats, and which all had been evaluated in experiments with ileal cannulated pigs, were used for the present study. There was a close relationship… Show more

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Cited by 15 publications
(7 citation statements)
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“…The NSP of the diets that mainly originates from ingredients wheat and oats in CONT were not completely fermented after passing the rat intestine. Fecal digestibility of total NSP in CONT diet were comparable to those reported for diets based on wheat and oats . Fermentation of cereal NSP present in CONT led to a high proportion of butyrate, which could be attributed to the stimulating effect of AXs on the production of butyrate, as reported before .…”
Section: Discussionsupporting
confidence: 84%
“…The NSP of the diets that mainly originates from ingredients wheat and oats in CONT were not completely fermented after passing the rat intestine. Fecal digestibility of total NSP in CONT diet were comparable to those reported for diets based on wheat and oats . Fermentation of cereal NSP present in CONT led to a high proportion of butyrate, which could be attributed to the stimulating effect of AXs on the production of butyrate, as reported before .…”
Section: Discussionsupporting
confidence: 84%
“…Alternative methods involving animal models that allow such differentiation are needed. The laboratory rat is a suitable choice for an animal model for humans owing to its low cost and ease of use . The upper gastrointestinal tracts of rats and humans are similar anatomically and both species are omnivorous.…”
Section: Introductionmentioning
confidence: 99%
“…We did not observe in this species the low true protein digestibility of RPI that we [4] and others [8,19,20] had previously evidenced in humans or other monogastric species. Rats may benefit from more efficient enzymatic equipment to digest hydrolysis-resistant rapeseed proteins than humans or pigs, and as such, are probably not a good model to study dietary protein digestibility in humans, unlike the pig [9,21], at least for dietary proteins with relatively slight differences in digestibility. In addition, RPI also did not differ from MPI in terms of postprandial metabolic losses of dietary N resulting from the deamination of dietary AA and excretion in urine.…”
Section: Discussionmentioning
confidence: 99%