The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris.

Gobel, Fredarick L.; Norstrom, L A; Nelson, Richard R.; Jorgensen, Charles R.; Wang, Y

doi:10.1161/01.cir.57.3.549

Cited by 767 publications

(407 citation statements)

References 57 publications

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“…These two indices showed a decrement following yogic practices due to decrease myocardial oxygen consumption and load on the heart. RPP is derived from SBP multiplied by HR, and DoP is derived from MBP multiplied by HR (Gobel et al 1978). Findings of this study show that HR and BP is positively correlated with age and may increase RPP and DoP.…”

Section: Discussionmentioning

confidence: 74%

“…RPP is an index of myocardial oxygen consumption, and DoP indicates load on heart (Gobel et al 1978). RPP and DoP were higher in the higher age group.…”

Section: Discussionmentioning

confidence: 99%

“…Mean blood pressure (MBP) was calculated as DP+1/3 PP. Double product (DoP) is an easily measurable index of load in the heart, and rate pressure product (RPP) is an easily measurable index of myocardial oxygen consumption, which were measured using heart rate and blood pressure (Gobel et al 1978). RPP was calculated as SBP×HR.…”

Section: Resting Physiological Parametersmentioning

confidence: 99%

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Age-related changes in cardiovascular system, autonomic functions, and levels of BDNF of healthy active males: role of yogic practice

Pal

Singh

Chatterjee

et al. 2014

AGE

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Aging is associated with decline in cardiovascular, autonomic function, and brain-derived neurotropic factor (BDNF). Reports are scanty regarding whether yoga can improve age-related degenerative changes in healthy active men. This study is designed to appraise the role of yoga in improving age-related degenerative changes in cardiometabolic risk profile, autonomic function, stress, and BDNF. Healthy active males of three age groups (20-29, 30-39, and 40-49 years) were randomly assigned to practice yoga daily 1 h for 3 months. Significantly higher values of heart rate (HR), blood pressure (BP), load in heart (DoP), myocardial oxygen consumption (RPP), and total cholesterol (TC) were noted in senior age group. HR, BP, DoP, RPP, and TC decreased significantly following yogic practice. High frequency (HF), total power (TP), all time domain variables of heart rate variability (HRV), and skin conductance (SC) were significantly decreased with advancement of age. HF, TP, and time domain parameters of HRV and SC increased significantly following yogic practice. Higher levels of catecholamines and low frequency (LF) power of HRV was noted with advancement of age. Levels of catecholamines and LF significantly decreased following yogic practice. Cortisol and adrenocorticotropic hormone (ACTH) level raised in senior age group. BDNF, serotonin, and dopamine were low in higher age group. Significant decrement of cortisol; ACTH; and increment in serotonin, dopamine, and BDNF was noted following yogic practice. This study revealed that yogic practices might help in the prevention of age-related degeneration by changing cardiometabolic risk factors, autonomic function, and BDNF in healthy male.

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Section: Discussionmentioning

confidence: 74%

“…RPP is an index of myocardial oxygen consumption, and DoP indicates load on heart (Gobel et al 1978). RPP and DoP were higher in the higher age group.…”

Section: Discussionmentioning

confidence: 99%

Section: Resting Physiological Parametersmentioning

confidence: 99%

See 1 more Smart Citation

Age-related changes in cardiovascular system, autonomic functions, and levels of BDNF of healthy active males: role of yogic practice

Pal

Singh

Chatterjee

et al. 2014

AGE

View full text Add to dashboard Cite

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“…24 The SEVR gives information about the balance between oxygen demands and endocardial blood flow. 25 The PRP, which refers to the product of SBP and HR during exercise, is a good measure of myocardial oxygen uptake 26 and it depends on exercise intensity. 27 To test for the intra-observer reproducibility of the method, the same operator (CL) performed measurements of AI in duplicate (within a time interval of 1 week) in a group of 16 different subjects.…”

Section: Pulse Wave Analysismentioning

confidence: 99%

Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise

et al. 2008

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Chronic dynamic (aerobic) exercise decreases central arterial stiffness, whereas chronic resistance exercise evokes the opposite effect. Nevertheless, there is little information available on the effects of acute bouts of exercise. Also, there is limited data showing an increase of central arterial stiffness during acute mental stress. This study aimed to determine the effect of acute mental and physical (static and dynamic exercise) stress on indices of central arterial stiffness. Fifteen young healthy volunteers were studied. The following paradigms were performed: (1) 2 min of mental arithmetic, (2) short bouts (20 s) of static handgrip at 20 and 70% of maximal voluntary contraction (MVC), (3) fatiguing handgrip at 40% MVC and (4) incremental dynamic knee extensor exercise. Central aortic waveforms were assessed using SphygmoCor software. As compared to baseline, pulse wave transit time decreased significantly for all four interventions indicating that central arterial stiffness increased. During fatiguing handgrip there was a fall in the ratio of peripheral to central pulse pressure from 1.69 ± 0.02 at baseline to 1.56±0.05 (Po0.05). In the knee extensor protocol a nonsignificant trend for the opposite effect was noted. The augmentation index increased significantly during the arithmetic, short static and fatiguing handgrip protocols, whereas there was no change in the knee extensor protocol. We conclude that (1) during all types of acute stress tested in this study (including dynamic exercise) estimated central stiffness increased, (2) during static exercise the workload posed on the left ventricle (expressed as change in central pulse pressure) is relatively higher than that posed during dynamic exercise (given the same pulse pressure change in the periphery).

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“…The DP has long been used as a non-invasive measure of myocardial oxygen consumption during exercise (Gobel et al 1978;Jorgensen et al 1973;Kitamura et al 1972). The DP has been a useful index in cardiac rehabilitation settings to identify specific workloads at which signs and symptoms of ischemia occur, and improvements in functional capacity relative to the onset of symptomatic ischemia (Arya et al 2005;Durstine and Tanaka and colleagues were the first to identify that the DP increases more rapidly above the LT than below it, and were the first to identify a breakpoint in the double product (DPBP) with incremental exercise in healthy subjects Tanaka and Shindo 1992).…”

Section: Introductionmentioning

confidence: 99%

The influence of aerobic exercise training on the double product break point in low-to-moderate risk adults

et al. 2010

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The double product (DP) is the product of the heart rate (HR) and systolic blood pressure (SBP). The double product break point (DPBP) is a physiologic threshold that occurs at similar exercise intensities to that of the ventilatory threshold (VT). The influence of aerobic exercise training on the DPBP has not yet been examined. The purpose of this study was to examine whether aerobic exercise training (ET) increases the exercise intensity at which the DPBP occurs, and whether it increases in a similar fashion to the VT. Seven males and 11 females, all sedentary (mean ± SD: age = 29.9 ± 10.5 yr) underwent supervised cardiopulmonary exercise testing using a cycle ergometer ramp protocol at baseline and after eight weeks of vigorous ET on a cycle ergometer. The VT was determined by gas analysis and the V-slope method. Experienced observers using standardized instructions visually determined the DPBP. Following ET, VO 2peak , maximal workload, and body composition variables all showed significant positive changes. The VO 2 at which the DPBP and VT occurred increased significantly from baseline to follow-up (p <.001). At baseline and at follow-up, the DPBP and VT did not differ. The DPBP and VT were significantly correlated to each other at both time points. Results suggest that the DPBP responds to ET in a similar fashion to that of the VT, and may be an easier and more useful marker of the VT for exercise training purposes.

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The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris.

Cited by 767 publications

References 57 publications

Age-related changes in cardiovascular system, autonomic functions, and levels of BDNF of healthy active males: role of yogic practice

Age-related changes in cardiovascular system, autonomic functions, and levels of BDNF of healthy active males: role of yogic practice

Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise

The influence of aerobic exercise training on the double product break point in low-to-moderate risk adults

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