The Rationale for Prostaglandin E1 in Erectile Failure: A Survey of Worldwide Experience

Porst, Hartmut

doi:10.1016/s0022-5347(01)66315-8

Cited by 305 publications

(205 citation statements)

References 80 publications

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“…The gold standard among intracavernous drugs for the treatment of ED is PGE l . 36 When the erection is inadequate, it can be combined with other drugs such as papaverine, phentolamine, and chlorpromazine. These combinations (PGE l þ phentolamine, PGE l þ papaverine, PGE l þ papaverine þ phentolamine, PGE l þ chlorpromazine) are used to treat patients who do not respond to a single drug or to reduce the side effects of the drug (pain in the case of PGE 1 , and fibrosis and prolonged erection in the case of papaverine).…”

Section: S22mentioning

confidence: 99%

“…37 The most common side effects include prolonged erections or priapism, penile pain, and fibrosis. 36,37 In the case of priapism, the patient should contact his physician if the erection is maintained for more than 4 h after injection so that measures can be taken to reverse it. Aspiration of blood and irrigation of the corpora cavernosa with saline, in addition to injection of adrenergic drugs, restore detumescence to the penis in virtually all cases, if the measures are not delayed for more than 6 h. ICI of phenylephrine at a dose of 0.2 mg every 5 min (maximum of three doses) may also be given.…”

Section: S22mentioning

confidence: 99%

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Specific aspects of erectile function in urology/andrology

et al. 2004

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The urologist/andrologist is the specialist responsible for diagnosis and treatment of health problems related to the genitourinary tract, and his or her participation in comprehensive care for a patient with erectile dysfunction (ED) is fundamental and often indispensable. The urologists/ andrologists should characterize the origin of ED because of their knowledge and familiarity of all diagnostic tests and second-and third-line therapy. The origin of ED is important to determine for various reasons, such as young people suitable for etiologic treatment, medicolegal reasons, or patients' wishes for a better understanding of their condition. A review of the diagnostic tests available as well as indications for second-and third-line therapy is presented. The close relationship between ED and urological disorders, such as benign prostatic hyperplasia, prostate cancer and their treatments, and renal failure, in association with penile conditions like Peyronie's disease, priapism, and possible androgen deficiency in men older than 50 years, places the urologist at the center of integrated treatment of male ED.

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Section: S22mentioning

confidence: 99%

Section: S22mentioning

confidence: 99%

Specific aspects of erectile function in urology/andrology

et al. 2004

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“…I1 est actuellement consid4r6 dans la plupart des pays comme le produit de r6f6rence pour le traitement par injections intracaverneuses, ayant 6galement re~u l'autorisation de mise sur le march6 dans plusieurs pays (CEDEX| et CAVERJECT| en France). I1 a 6t6 montr6 que tant le Moxisylyte que l'Alprostadil diminuaient l'incidence des complications typiquement associ6es ~ l'usage de la papav6rine et de l'association papav6rine-phentolamine, soit les 6rections prolong6es et la fibrose des corps caverneux [3,4,5,13,15]. L'Alprostadil-Alfadex (PGEla-cd) est une formulation originale de Prostaglandine E1 (PGE1) constitu4e par un complexe de PGE1 et d'alphacyclodextrine (Alfadex), un oligom6re de glucose cyclique.…”

Section: R 4 S U L T a T S : 56 S U J E T S D U G R O U P E A L P R Ounclassified

“…Score analogique visuel de 0 ~ 100 mn, off 0 6quivaut h ,,ce traitement ne me convient pas du touts) et 100 6qui-vaut h ,,ce traitement me convient parfaitement~). I1 a 6t6 rapport6 que l'Alprostadil induit une rigidit4 compl6te chez environ 70 % des sujets avec dysfonction 6rectile de routes origines lorsqu'on l'injecte au cabinet dans les corps caverneux [11,13,15]. Comme pour le Moxisylyte, la stimulation sexuelle ~ domicile augmente le taux des r4ponses positives.…”

Section: 9unclassified

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Comparaison randomisee en double insu d’injections intracaverneuses d’alprostadil-alfadex et de chlorhydrate de moxisylyte dans 156 cas de dysfonction erectile chronique

Buvat¹,

Amar

Cambau³

et al. 1998

Androl.

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RESUME B u t s : C o m p a r e r l'efficacit4 et la t o l 4 r a n c e de l ' A l p r o s t a d i l -A l f a d e x et d u c h l o r h y d r a t e d e M o x i s y l y t e p o u r r i n d u c t i o n d ' 4 r e c t i o n s com-p a t i b l e s a v e c u n r a p p o r t s e x u e l d a n s le c a d r e d ' u n e 4 t u d e p r o s p e c t i v e , r a n d o m i s 4 e , e n d o u b l e i n s u , a v e c g r o u p e s p a r a l l~l e s , c h e z des s u j e t s a v e c d y s f o n c t i o n 4rectile.M 4 t h o d e : 156 sujets a v e c d y s f o n c t i o n 4recti-le d ' o r i g i n e o r g a n i q u e , n o n -o r g a n i q u e , o u m i x t e , o n t 4ta r 4 p a r t i s d e f a g o n r a n d o m i s 4 e e n 2 g r o u p e s p a r a l l~l e s c h e z l e s q u e l s la q u e le t e s t 4 t a i t p o s i t i f e n c a s d ' 6 r e c t i o n d o n t la r i g i d i t 4 a x i a l e n e se d~f o r m a i t p a s (ne p l i a i t pas)sous r e f f e t d ' u n e c h a r g e de u n k i l o g r a m m e . Le ,,buckling t e s tf u t r 4 p~t 4 t o u t e s les 10 m i n u t e s p e n d a n t j u s q u e 60 m i n u t e s lorsqu'il 6tait positif. Les sujets p u r e n t e n s u i t e f a i r e 6 a u t o -i n j e c t i o n s domicile. Les invest i g a t e u r s j u g~r e n t les 6 r e c t i o n s i n d u i t e s comp a t i b l e s a v e c u n r a p p o r t s e x u e l c h e z 61 s u j e t s d u g r o u p e A l p r o s t a d i l -A l f a d e x ( 8 1 % ) c o n t r e 37 s u j e t s d u g r o u p e c h l o r h y d r a t e d e M o x i s y l y t e (46 %). Tous les p a r a m~t r e s 4va-l u a n t r e f f i c a c i t 4 a u c a b i n e t a t t e i g n i r e n t u n e s i g n i f i c a t i o n s t a t i s t i q u e a ve c u n p < 0.001 e n f a v e u r d e l ' A l p r o s t a d i l -A l f a d e x . P e n d a n t la p h a s e d ' a u t o -i n j e c t i o n h d o m i c i l e , 58 s u j e t s d u g r o u p e A l p r o s t a d i l -A l f a d e x (85 %) r a p p o rt b r e n t a v o i r e u a u m o i n s u n e 4 r e c t i o n rigide, p a r c o m p a r a i s o n h 37 sujets d u g r o u p e chlorh y d r a t e d e M o x i s y l y t e (61%). T a n t l ' o p i n i o n d e s p a t i e n t s q u e c e l l e d e l e u r s p a r t e n a i r e s s u r l ' i n t 4 r~t d u t r a i t e m e n t a t t e i g n i r e n t d e s s c o r e s s i g n i f i c a t i v e m e n t s u p 4 r i e u r s d a n s le g r o u p e Alprostadil-Alfadex, p a r c o m p a r a i s o n a u g r o u p e c h l o r h y d r a t e d e Moxisylyte. * Liste des investigateurs ayant particip4 h l'6tude : E. Amar, L. Boccon-Gibbod, Paris ; D. Morlier, G. Arvis, Paris ; J. Buvat, A. Lemaire, Lille ; O. Cambau, A. Leriche, Saint Genis Laval ; D. Chevallier, Nice ; P. Costa, H. Navratil, Nimes ; P. Desvaux, Clichy ; J. Hermabessi~re, Clermont-Ferrand ; F. Giuliano, A. Jardin, Le Kremlin Bic~tre, P. Lansiaux, Paris ; B. Dufour, Paris ; M. Schouman, Neuilly ; A. Gout, H. Zerbib, R. Debr6, Paris * Ce texte est la version franqaise de : Double-blind multicenter study comparing Alprostadil Alfadex with moxysylyte chlor...

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Quantitative determination of ?-cyclodextrin in human plasma by liquid chromatography/positive ion electrospray mass spectrometry

Hammes¹,

Bourscheidt²,

Büchsler³

et al. 2000

J. Mass Spectrom.

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A sensitive and selective method for the determination of α‐cyclodextrin in human plasma is described using β‐cyclodextrin as an internal standard. After protein precipitation with perchloric acid, the analytes were isolated from human plasma by solid‐phase extraction on Bond Elut C18 cartridges. The compounds were chromatographed on a narrow‐bore aminopropyl column (125 × 2 mm i.d., 5 µm) and analyzed by electrospray ionization mass spectrometry in the positive selected‐ion mode using the [M + NH4]+ ion. The lower limit of quantitation was 5 ng ml−1 of human plasma. Linear calibration curves were obtained over the concentration range 5–1000 ng ml−1 of human plasma. The intra‐ and inter‐assay precisions were <18% and the accuracy was <10.5% over the entire concentration range. During the method development, the ionization efficiencies of the analytes in plasma samples originating from different sources were examined to overcome the matrix effect problems caused by co‐eluting endogenous compounds. The method was successfully applied to pharmacokinetic studies in human volunteers. Copyright © 2000 John Wiley & Sons, Ltd.

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The Rationale for Prostaglandin E1 in Erectile Failure: A Survey of Worldwide Experience

Abstract: For self-injection therapy, PGE1 presently represents the most efficacious and safest drug. Ongoing trials with topical and especially intraurethral PGE1 are promising and may offer less invasive therapies in the near future.

Cited by 305 publications

References 80 publications

Specific aspects of erectile function in urology/andrology

Specific aspects of erectile function in urology/andrology

Comparaison randomisee en double insu d’injections intracaverneuses d’alprostadil-alfadex et de chlorhydrate de moxisylyte dans 156 cas de dysfonction erectile chronique

Quantitative determination of ?-cyclodextrin in human plasma by liquid chromatography/positive ion electrospray mass spectrometry

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