The Recent Impact of Solid-Phase Synthesis on Medicinally Relevant Benzoannelated Oxygen Heterocycles

Structure–activity relationships and mechanism of action of antitumor bis 8-hydroxyquinoline substituted benzylamines

“…Privileged substructures from bioactive natural products have played and continue to play an invaluable role in the drug discovery process [1][2][3] The diversification of these heterocyclic compounds using diversity-oriented synthesis (DOS) has been proven to be an essential tool to rapidly discover biologically active small molecules [4][5][6]. Therefore, the development of a concise and efficient strategy leading to skeletal and stereo chemical diversity has gained much attention in scientific communities involved in drug discovery and biomedical research [7].…”

Synthesis of 2-Phenylbenzofuran Derivatives and Selective Binding Activities on Estrogen Receptor

“…Due to their effective pharmacological activities, these compounds have been extensively studied. [1][2][3][4][5] A literature survey revealed that most 2-phenylbenzofurans with hydroxy and methoxy groups demonstrated multi-bioactivities, including antitumor, 6,7) anti-microbial, [8][9][10] antivirus, 11) adenosine A 1 receptor antagonists 12,13) and immunosuppressant properties. 14) In recent years, it is found that 2-phenylbenzofurans have significant binding affinity and selectivity on estrogen receptor (ER)β.…”

Transition Metal‐Catalyzed Synthesis of Fused Five‐Membered Aromatic Heterocycles

“…The benzo[b]furan moiety bearing different functional groups represents one of the most important heterocyclic pharmacophores and is often incorporated in many biologically active compounds and pharmaceutical agents as a core structural motif [61][62][63]. Furthermore, the benzo[b]furan skeleton is found in a variety of artificial materials with highly valuable properties and can be employed in the synthesis of diverse important synthons and final products [6,9,61,[64][65][66].…”

“…As a result, this heterocyclic unit continues to attract extensive synthetic efforts aimed at the development of selective and general methodologies for the facile assembly of the benzo [b] furan core. In particular, among a variety of synthetic protocols, recent research has been focused on the establishment of catalytic approaches from easily accessible precursors under mild reaction conditions [61,62,65,[67][68][69][70][71][72][73][74]. Special attention was given to transformations leading to the benzofuran heterocycle catalyzed by transition metals.…”