The recipient CXCL10 +1642C&gt;G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation

Nakata, Katsuya; Takami, Akiyoshi; Espinoza, J. Luis; Matsuo, Keitaro; Morishima, Yasuo; Onizuka, Makoto; Fukuda, Takahiro; Kodera, Yoshihisa; Akiyama, Hideki; Miyamura, Koichi; Mori, Takehiko; Nakao, Shinji

doi:10.1016/j.clim.2012.11.009

Cited by 15 publications

(9 citation statements)

References 27 publications

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“…The carriers of C/G or G/G genotypes had a significantly better 5-year survival rate and lower transplant-related mortality than the C/C genotype carriers. [18] In agreement with the findings of Pineda-Tenor et al, we found strong linkage disequilibrium between the CXCL9 and CXCL10 genotypes. [16]…”

Section: Discussionsupporting

confidence: 93%

Association between CXCL9/10 polymorphisms and acute rejection of liver allograft

et al. 2019

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Section: Discussionsupporting

confidence: 93%

Association between CXCL9/10 polymorphisms and acute rejection of liver allograft

et al. 2019

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“…Underlined and bold results represent P b 0.05. To the best of our knowledge, this is the first report identifying the same genotype of a single nucleotide variation in both the recipients and donors as having similar impacts on transplant outcomes among single nucleotide variations previously known to be significant [25][26][27][28][29][30]. This could result from the inherent nature of TLR1, which is ubiquitously expressed in various tissues such as white blood cells, lymph nodes, endothelium, lung, gut, skin, and liver, and plays critical roles in antimicrobial immunity [1,2].…”

Section: Discussionmentioning

confidence: 86%

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies

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et al. 2016

Transplant Immunology

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“…In detail, rs8878-derived allele was found to significantly enhance CXCL10 translation by increasing its mRNA half-life [ 18 ]. CXCL10 overexpression was demonstrated to be mediated also by rs3921-derived allele in patients affected by multiple sclerosis [ 58 ], invasive asperigillosis [ 59 ], and hematological malignancies [ 60 ]. Derived allele at rs3921 and CXCL9 rs10336 also turned out to boost CXCR3 expression, in addition to that of the respective genes, in patients with severe progression of Chagas cardiomyopathy [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Ancient pathogen-driven adaptation triggers increased susceptibility to non-celiac wheat sensitivity in present-day European populations

et al. 2016

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BackgroundNon-celiac wheat sensitivity is an emerging wheat-related syndrome showing peak prevalence in Western populations. Recent studies hypothesize that new gliadin alleles introduced in the human diet by replacement of ancient wheat with modern varieties can prompt immune responses mediated by the CXCR3-chemokine axis potentially underlying such pathogenic inflammation. This cultural shift may also explain disease epidemiology, having turned European-specific adaptive alleles previously targeted by natural selection into disadvantageous ones.MethodsTo explore this evolutionary scenario, we performed ultra-deep sequencing of genes pivotal in the CXCR3-inflammatory pathway on individuals diagnosed for non-celiac wheat sensitivity and we applied anthropological evolutionary genetics methods to sequence data from worldwide populations to investigate the genetic legacy of natural selection on these loci.ResultsOur results indicate that balancing selection has maintained two divergent CXCL10/CXCL11 haplotypes in Europeans, one responsible for boosting inflammatory reactions and another for encoding moderate chemokine expression.ConclusionsThis led to considerably higher occurrence of the former haplotype in Western people than in Africans and East Asians, suggesting that they might be more prone to side effects related to the consumption of modern wheat varieties. Accordingly, this study contributed to shed new light on some of the mechanisms potentially involved in the disease etiology and on the evolutionary bases of its present-day epidemiological patterns. Moreover, overrepresentation of disease homozygotes for the dis-adaptive haplotype plausibly accounts for their even more enhanced CXCR3-axis expression and for their further increase in disease risk, representing a promising finding to be validated by larger follow-up studies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12263-016-0532-4) contains supplementary material, which is available to authorized users.

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The recipient CXCL10 +1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation

Cited by 15 publications

References 27 publications

Association between CXCL9/10 polymorphisms and acute rejection of liver allograft

Association between CXCL9/10 polymorphisms and acute rejection of liver allograft

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies

Ancient pathogen-driven adaptation triggers increased susceptibility to non-celiac wheat sensitivity in present-day European populations

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