The reciprocal interaction between polyphenols and other dietary compounds: Impact on bioavailability, antioxidant capacity and other physico-chemical and nutritional parameters

Cianciosi, Danila; Forbes‐Hernández, Tamara Y.; Regolo, Lucia; Álvarez-Suárez, José M.; Navarro-Hortal, María D.; Xiao, Jianbo; Quiles, José L.; Battino, Maurizio; Giampieri, Francesca

doi:10.1016/j.foodchem.2021.131904

Cited by 74 publications

(36 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fraction 2 showed the highest antioxidant activity in almost all the assays performed ( Table 2 ), which could be ascribed to the presence of highly antioxidant compounds such as polyphenols and carotenoids, as previously mentioned [ 47 , 48 ]. The values were much higher than those obtained for the crude extract, indicating that the main antioxidative molecules were concentrated in the second fraction.…”

Section: Resultssupporting

confidence: 65%

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Calvo

Martín-Diana

Rico

et al. 2022

Foods

View full text Add to dashboard Cite

This study aims to determine the potential antioxidant, antihypertensive, hypoglycaemic and nootropic activity of a purified polyphenolic extract from the halophyte ice plant (Mesembryanthemum crystallinum). The ice plant extract showed good antioxidant activity measured by DPPH, ORAC, TEAC, FRAP and ferrous ion chelating activity. Moreover, the extract showed potent ACE, DPP-IV and PEP-inhibitory activity (90.5%, 98.6 % and 73.1%, respectively, at a final concentration of 1 mg/mL). The extract was fractionated and the fraction with the highest content of total phenolic compounds showed the highest bioactivity, suggesting that polyphenols could be mainly responsible for the abovementioned activities. The tentative polyphenol identification by HPLC-ESI-QTOF-MS in this fraction revealed that flavones (>65%) are the major group, with apigenin (38%) predominating, followed by diosmin (17.7%) and luteolin (11.9%). They could presumably be the main elements responsible for the enzymatic inhibition activity. Additionally, 4-hydroxybenzoic acid, p-coumaric acid and a hydroxycinnamic acid derivative (2-O-(p-cumaroyl)-l-malic acid) were found in the extract. To our knowledge, this is the first time that some of these activities have been reported for halophyte extracts.

show abstract

Section: Resultssupporting

confidence: 65%

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Calvo

Martín-Diana

Rico

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

“…The major tea catechins, including epigallocatechin‐3‐gallate, (‐)‐epicatechin 3‐ O ‐caffeoate, as well as etc‐pyrrolidinone C and D, possessed strong inhibitory effects toward 3CL pro 188–192 . In addition, some flavonoids, such as kaempferol, luteolin, genkwanin, and isorhamnetin, displayed various degrees of inhibitory activities toward 3CL pro 192,193 …”

Section: Naturally Derived Sars‐cov‐2 3clpro Inhibitorsmentioning

confidence: 99%

“…However, the bioavailability of naturally occurring flavonoids is generally poor, which are easily glycosylated by UDP‐glucuronosyltransferases in vivo 194 . The metabolites (glycosyl flavonoids) have better solubility, stability, and bioavailability properties than their aglycones 193,195,196 . Some molecular docking and simulation studies found that glycosyl flavonoids calculated a high‐affinity score for binding to 3CL pro 197–200 .…”

Section: Naturally Derived Sars‐cov‐2 3clpro Inhibitorsmentioning

confidence: 99%

The SARS‐CoV‐2 main protease (M^pro): Structure, function, and emerging therapies for COVID‐19

Xiong

Zhu

et al. 2022

MedComm

129

View full text Add to dashboard Cite

The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has demonstrated that 3CLpros play an indispensable role in viral replication and have been recognized as key targets for preventing and treating coronavirus‐caused infectious diseases, including COVID‐19. This review is focused on the structural features and biological function of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) main protease Mpro (also known as 3CLpro), as well as recent advances in discovering and developing SARS‐CoV‐2 3CLpro inhibitors. To better understand the characteristics of SARS‐CoV‐2 3CLpro inhibitors, the inhibition activities, inhibitory mechanisms, and key structural features of various 3CLpro inhibitors (including marketed drugs, peptidomimetic, and non‐peptidomimetic synthetic compounds, as well as natural compounds and their derivatives) are summarized comprehensively. Meanwhile, the challenges in this field are highlighted, while future directions for designing and developing efficacious 3CLpro inhibitors as novel anti‐coronavirus therapies are also proposed. Collectively, all information and knowledge presented here are very helpful for understanding the structural features and inhibitory mechanisms of SARS‐CoV‐2 3CLpro inhibitors, which offers new insights or inspiration to medicinal chemists for designing and developing more efficacious 3CLpro inhibitors as novel anti‐coronavirus agents.

show abstract

“…Plant polyphenols have been intensively investigated due to their potential positive health effects and the possibility of using them in animal nutrition and health [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. The biological activity of polyphenols is highly structure-dependent, and in biological applications, the bioavailability and bioaccessibility of polyphenols and their interactions with other compounds present in the plant matrices play an important role [ 2 , 11 , 12 ].…”

Section: Introduction To Polyphenol–lipid Interactionsmentioning

confidence: 99%

“…The interactions of polyphenols with the other macromolecules have not been studied as comprehensively, but for example, polyphenols do interact with the various cell components such as pectin, cellulose and fibers [ 11 , 14 , 15 , 16 ] and also with the nucleic acids [ 17 ]. These interactions between polyphenols and macromolecules are complex and also affected by micronutrients such as minerals, vitamins and organic pigments as well as environmental factors such as pH and temperature [ 12 , 18 ]. The affinity of polyphenols for lipid bilayers partially determines their biological activity in vitro [ 19 ] and is also important from the medical and dietary points of view [ 20 ].…”

Section: Introduction To Polyphenol–lipid Interactionsmentioning

confidence: 99%

Insights into Polyphenol–Lipid Interactions: Chemical Methods, Molecular Aspects and Their Effects on Membrane Structures

Karonen

2022

Plants

View full text Add to dashboard Cite

Plant polyphenols have many potential applications, for example, in the fields of chemical ecology and human and animal health and nutrition. These biological benefits are related to their bioavailability, bioaccessibility and interactions with other biomolecules, such as proteins, lipids, fibers and amino acids. Polyphenol–protein interactions are well-studied, but less is known about their interactions with lipids and cell membranes. However, the affinity of polyphenols for lipid bilayers partially determines their biological activity and is also important from the usability perspective. The polyphenol–lipid interactions can be studied with several chemical tools including, among others, partition coefficient measurements, calorimetric methods, spectroscopic techniques and molecular dynamics simulation. Polyphenols can variably interact with and penetrate lipid bilayers depending on the structures and concentrations of the polyphenols, the compositions of the lipids and the ambient conditions and factors. Polyphenol penetrating the lipid bilayer can perturb and cause changes in its structure and biophysical properties. The current studies have used structurally different polyphenols, diverse model lipids and various measuring techniques. This approach provides detailed information on polyphenol–lipid interactions, but there is much variability, and the results may even be contradictory, for example, in relation to the locations and orientations of the polyphenols in the lipid bilayers. Nevertheless, by using well-characterized model polyphenols and lipids systematically and combining the results obtained with several techniques within a study, it is possible to create a good overall picture of these fascinating interactions.

show abstract

The reciprocal interaction between polyphenols and other dietary compounds: Impact on bioavailability, antioxidant capacity and other physico-chemical and nutritional parameters

Cited by 74 publications

References 121 publications

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

The SARS‐CoV‐2 main protease (M^pro): Structure, function, and emerging therapies for COVID‐19

Insights into Polyphenol–Lipid Interactions: Chemical Methods, Molecular Aspects and Their Effects on Membrane Structures

Contact Info

Product

Resources

About

The reciprocal interaction between polyphenols and other dietary compounds: Impact on bioavailability, antioxidant capacity and other physico-chemical and nutritional parameters

Cited by 74 publications

References 121 publications

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19

Insights into Polyphenol–Lipid Interactions: Chemical Methods, Molecular Aspects and Their Effects on Membrane Structures

Contact Info

Product

Resources

About

The SARS‐CoV‐2 main protease (M^pro): Structure, function, and emerging therapies for COVID‐19