The Regulatory-T-Cell Memory Phenotype: What We Know

Khantakova, Julia N.; Bulygin, Aleksey S.; Sennikov, Sergey

doi:10.3390/cells11101687

Cited by 23 publications

(16 citation statements)

References 168 publications

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“…The dysregulation of Tregs has been identified in the pathogenesis of autoimmune diseases and cancer. These cells are capable of secreting anti-inflammatory cytokines, such as IL-10 [ 117 ]. The dysregulation of the Th17/Treg balance has been identified in psoriasis.…”

Section: Adiponectinmentioning

confidence: 99%

The Role of Adipokines in the Pathogenesis of Psoriasis

Kiełbowski

Bakinowska

Ostrowski

et al. 2023

IJMS

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Psoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL-17 pathway enhances the disease progression. Human adipose tissue is an endocrine organ, which secretes multiple proteins, known as adipokines, such as adiponectin, leptin, visfatin, or resistin. Current evidence highlights the immunomodulatory roles of adipokines, which may contribute to the progression or suppression of psoriasis. A better understanding of the complexity of psoriasis pathophysiology linked with adipokines could result in developing novel diagnostic or therapeutic strategies. This review aims to present the pathogenesis of psoriasis and the roles of adipokines in this process.

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Section: Adiponectinmentioning

confidence: 99%

The Role of Adipokines in the Pathogenesis of Psoriasis

Kiełbowski

Bakinowska

Ostrowski

et al. 2023

IJMS

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“…Overall, the phenotypic diversity of regulatory T cells allows them to access various tissues, including brain tissue, where they implement immune homeostasis (Tanoue et al, 2016 ; Khantakova et al, 2022b ). In the CNS, regulatory T cells play a major part in the regulation of inflammation.…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

Once induced, it lasts for a long time: the structural and molecular signatures associated with depressive-like behavior after neonatal immune activation

Khantakova

Bondar

Antontseva

et al. 2022

Front. Cell. Neurosci.

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Adverse factors such as stress or inflammation in the neonatal period can affect the development of certain brain structures and have negative delayed effects throughout the lifespan of an individual, by reducing cognitive abilities and increasing the risk of psychopathologies. One possible reason for these delayed effects is the neuroinflammation caused by neonatal immune activation (NIA). Neuroinflammation can lead to disturbances of neurotransmission and to reprogramming of astroglial and microglial brain cells; when combined, the two problems can cause changes in the cytoarchitecture of individual regions of the brain. In addition, neuroinflammation may affect the hypothalamic–pituitary–adrenal (HPA) axis and processes of oxidative stress, thereby resulting in higher stress reactivity. In our review, we tried to answer the questions of whether depressive-like behavior develops after NIA in rodents and what the molecular mechanisms associated with these disorders are. Most studies indicate that NIA does not induce depressive-like behavior in a steady state. Nonetheless, adult males (but not females or adolescents of both sexes) with experience of NIA exhibit marked depressive-like behavior when exposed to aversive conditions. Analyses of molecular changes have shown that NIA leads to an increase in the amount of activated microglia and astroglia in the frontal cortex and hippocampus, an increase in oxidative-stress parameters, a change in stress reactivity of the HPA axis, and an imbalance of cytokines in various regions of the brain, but not in blood plasma, thus confirming the local nature of the inflammation. Therefore, NIA causes depressive-like behavior in adult males under aversive testing conditions, which are accompanied by local inflammation and have sex- and age-specific effects.

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“…CD47 expression on stromal cells contributes not only contribute to angiogenesis and tumor growth but also to immune evasion [7,41,42]. For instance, CD47 on endothelial cells inhibits T cell trafficking into the TME, while CD47 on fibroblasts promotes immunosuppressive functions of Treg [43]. Therefore, CD47 expression on stromal cells significantly impacts tumor growth and progression.…”

Section: Cd47 Function In the Tme And Signaling Pathwaysmentioning

confidence: 99%

Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy

CHEN,

GUO,

2024

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Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy. However, the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely understood. This comprehensive review aims to provide an overview of CD47's multifaced role in TME regulation and immune evasion, elucidating its impact on various types of immunotherapy outcomes, including checkpoint inhibitors and CAR T-cell therapy. Notably, CD47-targeted therapies offer a promising avenue for improving cancer treatment outcomes, especially when combined with other immunotherapeutic approaches. The review also discusses current and potential CD47-targeted therapies being explored for cancer treatment and delves into the associated challenges and opportunities inherent in targeting CD47. Despite the demonstrated effectiveness of CD47-targeted therapies, there are potential problems, including unintended effects on healthy cells, hematological toxicities, and the development if resistance. Consequently, further research efforts are warranted to fully understand the underlying mechanisms of resistance and to optimize CD47-targeted therapies through innovative combination approaches, ultimately improving cancer treatment outcomes. Overall, this comprehensive review highlights the significance of CD47 as a promising target for cancer immunotherapy and provides valuable insight into the challenges and opportunities in developing effective CD47-targeted therapies for cancer treatment.

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The Regulatory-T-Cell Memory Phenotype: What We Know

Cited by 23 publications

References 168 publications

The Role of Adipokines in the Pathogenesis of Psoriasis

The Role of Adipokines in the Pathogenesis of Psoriasis

Once induced, it lasts for a long time: the structural and molecular signatures associated with depressive-like behavior after neonatal immune activation

Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy

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