The Relation Between Regional Ileitis and Sarcoidosis

The immune competence of patients with inflammatory bowel disease

“…In contrast, patients with Crohn's disease have shown a high incidence of negative Mantoux responses (Blackburn, Hadfield, and Hunt, ,1939;Phear, 1958;Williams, 1965), as well as diminished cutaneous delayed hypersensitivity reactions to dinitrochlorobenzene (Jones, Housley, Ashurst, and Hawkins, 1969). Also the lymphocytes of patients with Crohn's disease have shown low responses to nonspecific mitogens such as phytohaemagglutinin (Walker and Greaves, 1969;Brown, Taub, Present, and Janowitz, 1970;Parent et al, 1971).…”

An attempt to devise a skin test for regional enteritis

“…The Mantoux reaction is 70 %Y negative in sarcoidosis (James, 1956), and the same low response rate has been reported in regional enteritis (Blackburn, Hadfield, and Hunt, 1939;Phear, 1958). These similarities provided the rationale for an attempt to devise a skin test for regional enteritis analogous to the Kveim test for sarcoidosis.…”

A study of Crohn's syndrome using tissue extracts and the Kveim and Mantoux tests.

“…In an earlier series of 24 cases (Williams, 1963), the incidence was 67% and now with an additional 26 cases the incidence is 64%. Blackburn, Hadfield, and Hunt (1939) and Phear (1958) gave an incidence of between 70% and 80%.…”