The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran

Fayazi, Haniye Sadat; Yaseri, Maryam; Mortazavi, Seyyede Sahere; Sharifhassan, Zahra; Assadinia, Ali-Sina

doi:10.1186/s12902-022-00952-5

Cited by 12 publications

(17 citation statements)

References 25 publications

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“…Hyperuricemia was reported to be related to endothelial dysfunction and oxidative stress [ 31 , 32 ]. Our study showed that hyperuricemia was connected to an increased DPN risk, consistent with other studies [ 26 , 33 ]. Nevertheless, another cross-sectional study described a contrary relationship between large-nerve fiber dysfunction and UA levels in diabetic patients [ 34 ].…”

Section: Discussionsupporting

confidence: 93%

“…A higher cumulative incidence of DPN was observed in male than female patients in young adults [ 25 ]. However, another study with Iranian participants came to an opposite conclusion [ 26 ]. Numerous studies, including our research, indicated that T2DM patients with longer disease duration were more likely to develop DPN [ 9 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

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A Nomogram for Predicting the Possibility of Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus

Zhang

Chen

2022

Brain Sciences

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Background and Purpose: Diabetic peripheral neuropathy (DPN) leads to ulceration, noninvasive amputation, and long-term disability. This study aimed to develop and validate a nomogram for forecasting the probability of DPN in type 2 diabetes mellitus patients. Methods: From February 2017 to May 2021, 778 patients with type 2 diabetes mellitus were included in this study. We confirmed the diagnosis of DPN according to the Toronto Expert Consensus. Patients were randomly divided into a training cohort (n = 519) and a validation cohort (n = 259). In the training cohort, univariate and multivariate logistic regression analyses were performed, and a simple nomogram was built using the stepwise method. The receiver operating characteristic (ROC), calibration curve, and decision curve analysis were computed in order to validate the discrimination and clinical value of the nomogram model. Results: About 65.7% and 72.2% of patients were diagnosed with DPN in the training and validation cohorts. We developed a novel nomogram to predict the probability of DPN based on the parameters of age, gender, duration of diabetes, body mass index, uric acid, hemoglobin A1c, and free triiodothyronine. The areas under the curves (AUCs) of the nomogram model were 0.763 in the training cohort and 0.755 in the validation cohort. The calibration plots revealed well-fitted accuracy between the predicted and actual probability in the training and validation cohorts. Decision curve analysis confirmed the clinical value of the nomogram. In subgroup analysis, the predictive ability of the nomogram model was strong. Conclusions: The nomogram of age, gender, duration of diabetes, body mass index, uric acid, hemoglobin A1c, and free triiodothyronine may assist clinicians with the early identification of DPN in patients with type 2 diabetes mellitus.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

A Nomogram for Predicting the Possibility of Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus

Zhang

Chen

2022

Brain Sciences

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“…In study by Fayazi et al (17) , a total of 230 patients with type 2 diabetes were examined. The mean SUA level in the DPN group was significantly higher compared to DM without neuropathy (6.72 ± 1.75 vs. 4.57 ± 1.49 mg/dL).…”

Section: Discussionmentioning

confidence: 99%

“…The correlation between DPN and SUA was mediated by several mechanisms which were reported by several studies. SUA serves as an antioxidant during the vascular passage, and on the contrary it has a reverse action in vascular smooth myocytes as it promotes the release and production of NO forming vascular impairment and DPN progression (17) . Some researchers have suggested that UA is closely related to DN that occurs shortly after hyperuricemia in patients with type 1 diabetes mellitus (T1DM), which can independently predict its occurrence (16) .…”

Section: Discussionmentioning

confidence: 99%

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Study of Serum Uric Acid in Relation to Diabetic Neuropathy in Type 2 Diabetic Patients

Awad¹,

Elsayed²,

Samy³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Diabetic peripheral neuropathy (DPN) considered a potential complication correlated with diabetes type 1 and type 2 (T2DM). Objective: The present study was aimed for better control of T2DM complications such as diabetic DPN and to assess the relationship between serum uric acid (SUA) level and DPN. Patients and Methods: This cross-sectional study was carried out in Internal Medicine Outpatient Clinics, Zagazig University Hospital and El Ahrar Teaching Hospital. The study included 50 patients; aged between 42 and 78 years, divided into two groups, diabetic group without neuropathy (DM) and diabetic group with peripheral neuropathy. Results: The findings revealed that there was a statistically insignificant difference between DM, and DPN groups and gender, age, weight, height, BMI. There was a significant difference between the two studied groups and duration of diabetes and SUA. There was a statistically insignificant difference between DM and DPN groups and type of medication, systolic BP, diastolic BP, Hemoglobin A1c, and fasting blood glucose. Conclusion: It could be concluded that elevated SUA level increased the chance of developing peripheral neuropathy in a person with type 2 diabetes (T2DM). Many animal experiments and large-scale clinical observations and experiments are needed to confirm this observation.

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Vitamin D Reduces the Activity of Adenosine Deaminase and Oxidative Stress in Patients with Type Two Diabetes Mellitus

Alfaqih,

Ababneh,

Mhedat

et al. 2024

Molecular Nutrition Food Res

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ScopePatients with Type 2 diabetes mellitus (T2DM) have lower levels of vitamin D. An elevation in uric acid (UA) contributes to T2DM via an increase in oxidative stress. Adenosine deaminase (ADA) is an enzyme of the purine degradation pathway. It is hypothesized that a reduction of ADA activity via vitamin D supplementation reduces UA and oxidative stress.Methods and resultsA total of 162 participants (81 with T2DM and 81 controls) are enrolled in a case–control study. A follow‐up interventional study is performed on 30 patients with vitamin D deficiency. These patients receive 50 000 IU (international units) of vitamin D3 on a weekly basis for 12 weeks. This intervention is followed by the measurement of several markers. T2DM patients has higher ADA activity, UA, and lipid peroxidation but lower 25‐hydroxy‐vitamin D (25 (OH) vitamin D) and GSH/GSSG ratio (p < 0.05). Vitamin D supplementation results in a reduction of ADA activity and UA levels (p < 0.05) along with an increase in GSH/GSSG ratio (p < 0.05).ConclusionThe results highlight the presence of an axis in T2DM patients between ADA, UA, and oxidative stress. Modulation of this axis can be achieved by clinically approved vitamin D supplementation protocols.

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The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran

Cited by 12 publications

References 25 publications

A Nomogram for Predicting the Possibility of Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus

A Nomogram for Predicting the Possibility of Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus

Study of Serum Uric Acid in Relation to Diabetic Neuropathy in Type 2 Diabetic Patients

Vitamin D Reduces the Activity of Adenosine Deaminase and Oxidative Stress in Patients with Type Two Diabetes Mellitus

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