The Relation of ABO Blood Group to the Severity of Coronavirus Disease: A Cross-Sectional Study From a Tertiary Care Hospital in Karachi

Rehman, Fazal Ur; Omair, Syed Furrukh; Memon, Fatima; Rind, Bakhtawar J; Memon, Danish; Ahmed, Bilal; Ali, Naureen Akber

doi:10.7759/cureus.16598

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…In his detailed analysis, Bhattacharjee further supported this with data indicating a higher frequency of Blood Group-A in patients with severe COVID-19. 24 Our study diverges from the results obtained by Rehman FU et al, 25 Hafiz W et al 26 and Bryce E Pasko et al 27 who found no significant association between blood groups and disease severity. In studies by Barnkob et al 28 and Dite et al 29 Blood Group-O, individuals were less likely to contract the virus, whereas blood Group-A was associated with an increased risk.…”

Section: Abo Has Four Fundamental Phenotypes: O a Bcontrasting

confidence: 91%

Effect of ABO blood group on the severity and clinico-pathological parameters of COVID-19

Asad,

Mirza,

Kumar

et al. 2024

Pak J Med Sci

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Background and Objective: The COVID-19 pandemic has highlighted the need to understand the factors affecting disease severity. Prior research has indicated the potential roles of the ABO blood group system in disease susceptibility and progression. Our objective was to investigate the association between ABO Blood groups and the severity of COVID-19 and clinicopathological parameters. Methods: An analytical cross-sectional study was conducted across three locations of Ziauddin University Hospital, including COVID-19 outpatient departments (OPDs), wards, and intensive care units (ICUs) from May 2020 to December 2020.The study utilized a non-probability convenient sampling technique with a sample size of 120 PCR-positive adult patients, as calculated by OpenEpi with a 95% confidence interval. Patients were excluded if they were under 14, intellectually impaired, post-chemotherapy or radiotherapy, or had a malignant condition. Disease severity was determined based on clinicopathological parameters and associated with blood group data using ANOVA and Chi-square tests in SPSS version 21. Results: A significant association was found between the ABO blood groups and COVID-19 severity. Blood group-A was notably overrepresented in patients with severe COVID-19 and correlated with higher inflammatory markers and coagulation parameters. Conclusion: ABO blood group, particularly Blood Group-A significantly associates with the severity of COVID-19. This finding suggests the potential utility of ABO blood group typing as a predictive marker for disease severity, which could contribute to personalized patient management strategies. Further research is necessary to understand the mechanisms underlying this association. doi: https://doi.org/10.12669/pjms.40.5.9037 How to cite this: Asad L, Mirza T, Kumar S, Khatoon A. Effect of ABO blood group on the severity and clinico-pathological parameters of COVID-19. Pak J Med Sci. 2024;40(5):---------. doi: https://doi.org/10.12669/pjms.40.5.9037 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Abo Has Four Fundamental Phenotypes: O a Bcontrasting

confidence: 91%

Effect of ABO blood group on the severity and clinico-pathological parameters of COVID-19

Asad,

Mirza,

Kumar

et al. 2024

Pak J Med Sci

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“…Fazal et al also added to the literature and showed that the B blood group was the most frequent among covid-19 patients in Karachi, followed by O, A and AB. However, according to this study blood groups have no role in predicting the severity of the disease [64].…”

Section: Association With Heart Diseasesmentioning

confidence: 62%

Prevalence Of Blood Groups And Association With Ailments In Pakistani Population: A Review of The Current Literature

et al. 2023

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The aim of this review is to report studies performed in Pakistan on the prevalence of blood groups among various sections of the population and their association with human diseases. Google Scholar was searched for the last 20 years based on MESH keywords mentioned below. The inclusion criteria were the studies published in the new millennium that reported either prevalence of blood groups or their association with diseases in the Pakistani population. There were 50 studies in Pakistan which fulfill the inclusion criteria. Among them, twenty- six were from Punjab, seven were from Khyber Pakhtunkhwa (KpK), six from Sindh, four from Kashmir, two from Northern areas, one from Baluchistan and 4 are review articles. This review concludes that blood group B is prevalent among Pakistani population followed by O, A and AB. Studies done in Azad Jammu Kashmir (AJK) and Gilgit- Baltistan reveal that B and A is prevalent in these areas respectively. AB is the least found group and Rh+ve is common among all studies. Moreover, this review also shows that blood groups act as a risk factor for many diseases. Therefore, Pakistani researchers are suggested to work on the genetic makeup of these blood groups to find out the cause of association with systemic ailments in the country.

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“…Regarding ABO blood types, there were contradictory findings amongst different studies. A study from Pakistan reported a lower occurrence of anosmia or ageusia with blood group O (30.0%) compared to blood group B (39.5%) and lower chances of showing severe symptoms of COVID-19 overall [ 11 ]. A study conducted in Spain concluded otherwise; they found that group O had an increased susceptibility to more severe symptoms [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Chemosensitive Neurological Disorders of Smell and Taste and Association with Blood Groups in SARS-CoV-2 Patients: Cross-Sectional Study

Al-Shouli,

Meo,

Alafaleq

et al. 2023

Viruses

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The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a highly challenging and threatening situation worldwide. SARS-CoV-2 patients develop various clinical symptoms. The olfactory and taste dysfunctions are potential neurological manifestations among SARS-CoV-2 patients; however, their relationship with blood groups has rarely been investigated. This study aimed to investigate the prevalence of chemosensitive neurological disorders of smell and taste and their association with blood groups in SARS-CoV-2 patients. The present cross-sectional study was performed in the Department of Pathology, and Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. A well-structured, self-administered questionnaire was designed and distributed through social media platforms. A total of 922 Saudi and non-Saudi adults aged 18 years or older participated in the study. Out of 922 participants, the number of people who had anosmia was 309 (33.5%), 211 (22.9%) had hyposmia, and 45 (4.8%) had dysosmia. Moreover, 180 (19.52%) had ageusia, 47 (5.1%) and 293 (31.8%) had hypogeusia and dysgeusia, respectively. Among all the participants, 565 (61.27%) had smell-related disorders and 520 (56.39%) participants had taste-related clinical symptoms. The occurrence of anosmia and ageusia was relatively high among females compared to males (p = 0.024). The prevalence of smell-related disorders was 25.0% (230) and taste-related disorders was 23.21% (214) among the study participants with blood group O compared to all other blood group (A, B, and AB) participants who have smell allied disorders 30.69% (283), and taste allied disorders 27.98% (258). The prevalence of chemosensitive neurological disorders involving impaired smell and taste was higher in SARS-CoV-2 patients. These clinical symptoms were common among the participants with blood group type O compared to all other ABO blood group types. The role of certain demographic characteristics was consistent throughout multiple studies, notably with female gender and young adults.

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The Relation of ABO Blood Group to the Severity of Coronavirus Disease: A Cross-Sectional Study From a Tertiary Care Hospital in Karachi

Cited by 4 publications

References 18 publications

Effect of ABO blood group on the severity and clinico-pathological parameters of COVID-19

Effect of ABO blood group on the severity and clinico-pathological parameters of COVID-19

Prevalence Of Blood Groups And Association With Ailments In Pakistani Population: A Review of The Current Literature

Prevalence of Chemosensitive Neurological Disorders of Smell and Taste and Association with Blood Groups in SARS-CoV-2 Patients: Cross-Sectional Study

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