The relation of PON1-L55M gene polymorphism and clinical manifestation of Behcet's disease.

Abstract

Purpose: Behçet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Paraoxonase is believed to play an important role in protection of LDL and HDL particles from oxidation, in antioxidant effect against lipid peroxidation on cellular membranes, and in anti-inflammatory process. Lipid peroxidation and free oxygen radicals have been thought to play a role in pathogenesis of BD. The association of paraoxonase gene polymorphisms with Behçet's Disease in a group of Turkish patients with clinical manifestations and healthy controls has been investigated. Patients and Methods: Paraoxonase (PON-1-L55M) gene polymorphism was investigated in 50 Behcet patients and 50 healthy individuals with a PCR/RFLP method. Results: There were significant differences between patients and the control group in allele frequencies of the PON1 L55M polymorphism (p=0.04). Also, when patients were compared with the control group according to clinical manifestations, this statistical significance was getting sharper. Compared with the PON55 L allele, the M allele was associated with greater than 3.5 fold (OR 3.5, 95% CI 1.3-8.9) increased risk of ocular (OR 2.4, 95% CI 1.1-5.3), 2.4 fold joint and 3.1 fold (OR 3.1, 95% CI 1.1-8.4) central nervous system manifestations of BD. Conclusion The PON L55M gene polymorphism seemed to play a role in the pathogenesis of BD.

Association of PON2 and PON3 polymorphism with risk of developing cataract

“…Both enzymes are capable to restrain LDL oxidation 34 and trigger antioxidant properties along with cholesterol efflux of HDL [35], [36]. Association of PON2 and PON3 polymorphism with various disorders has sparingly been studied [14], [15], [16], [17], [18], [19], [20], [21]. Present study was conducted to explore association between senile cataract and PON2 and PON3 polymorphism.…”

“…Paraoxonases are calcium dependent antioxidant enzymes constituting three isoforms PON1, PON2 and PON3 10 . PON1 polymorphism has been studied in different disorders including cataract,[11], [12] diabetes, 13 age related macular degeneration, 14 Alzheimer’s disease, 15 Behcet’s disease, 16 and atherosclerosis 17 . Data for PON2 and PON3, however, is limited.…”

Investigation of Paraoxanase Enzyme Polymorphism in Patients with Alopecia Areata

“…Asefi et al (24) asserted that PON1 55 M allele is a risk factor for the psoriasis. Dursun et al (25) reported that there was a relation between PON1 55 M allele polymorphism and Behçet disease. Although there were no significant differences between the groups with respect to PON1 L55M polymorphism, Gürel et al 9 presence of increased frequency in AA group makes us think, there may be a weak relation between PON1 L 55 M polymorphism and AA.…”