The relationship between age and pelvic organ prolapse bother

Kinman, Casey L.; Lemieux, Courtney A.; Agrawal, Anubhav; Gaskins, Jeremy; Meriwether, Kate V.; Francis, Sean L.

doi:10.1007/s00192-016-3175-5

Cited by 26 publications

(21 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The findings of this study showed that the expression of klotho was significantly down-regulated in the pelvic tissue fibroblasts collected from patients with pelvic organ prolapse (POP), at both the mRNA and protein expression levels. There is increasing evidence for the relationship between the expression of klotho proteins and POP, as both of them are associated with the aging process [16–19]. POP is more common in elderly women [16].…”

Section: Discussionmentioning

confidence: 99%

“…There is increasing evidence for the relationship between the expression of klotho proteins and POP, as both of them are associated with the aging process [16–19]. POP is more common in elderly women [16]. Klotho protein expression has been shown to have a role in the suppression of several aging phenotypes, including muscle atrophy [9].…”

Section: Discussionmentioning

confidence: 99%

“…However, it is possible that a relationship exists between the expression of klotho protein and POP as both are associated with the aging process [16–19]. Older women are at an increased risk from weakening of the muscles of the pelvic floor [16]. Recent preclinical studies using KL (−/−) knockout mice demonstrated muscle and connective tissue atrophy [9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Klotho Protein Reduced the Expression of Matrix Metalloproteinase-1 (MMP-1) and Matrix Metalloproteinase-3 (MMP-3) in Fibroblasts from Patients with Pelvic Organ Prolapse (POP) by Down-Regulating the Phosphorylation of ERK1/2

et al. 2019

View full text Add to dashboard Cite

Background Pelvic organ prolapse (POP) is due to age-related atrophy and the weakening of the tissues of the pelvic floor, with degradation of collagen and extracellular matrix (ECM) by metalloproteinases (MMPs). This study aimed to investigates the role of the age-related enzyme klotho, encoded by the KL gene, in cultured fibroblasts obtained from patients with POP and the levels of reactive oxygen species (ROS), interleukin-6 (IL-6), and MMPs. Material/Methods Pelvic floor fibroblasts were obtained from connective tissue from three patients with POP and three normal subjects. Cell proliferation and ROS production were measured using a cell counting kit-8 (CCK-8) assay and flow cytometry. Levels of interleukin-6 (IL-6), klotho, metalloproteinase-1 (MMP-1), MMP-3, extracellular signal-regulated kinases 1/2 (ERK1/2), and p-ERK1/2 were measured by enzyme-linked immunoassay (ELISA), quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot. Results In cultured pelvic floor fibroblasts from patients with POP, the expression of klotho protein and klotho mRNA were significantly down-regulated in fibroblasts from patients with POP compared with normal fibroblasts. Klotho supplementation in cultured fibroblasts for patients with POP included increased cell growth, reduced expression of ROS reduction, and reduced the secretion of IL-6. Using qRT-PCR and Western blot, klotho supplementation of fibroblasts from patients with POP increased cell growth and reduced the levels of IL-6 and ROS in a dose-dependent way. Conclusions Klotho protein reduced the expression of MMP-1 and MMP-3 in fibroblasts from patients with POP by down-regulating the phosphorylation of ERK1/2.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Klotho Protein Reduced the Expression of Matrix Metalloproteinase-1 (MMP-1) and Matrix Metalloproteinase-3 (MMP-3) in Fibroblasts from Patients with Pelvic Organ Prolapse (POP) by Down-Regulating the Phosphorylation of ERK1/2

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It is ubiquitous that the increase by weight contributes harmful influence on health of females and it also contributes to POP pathogenesis. The studies of Bradley and Kudish suggested that obesity was risky for POP and increase of BMI bring higher morbidity [36,37]. Another important risk factor is vaginal delivery.…”

Section: Plos Onementioning

confidence: 99%

COL3A1 rs1800255 polymorphism is associated with pelvic organ prolapse susceptibility in Caucasian individuals: Evidence from a meta-analysis

Ning

2021

PLoS ONE

View full text Add to dashboard Cite

Background The collagen 3 alpha 1 (COL3A1) rs1800255 polymorphism has been reported to be associated with women pelvic organ prolapse (POP) susceptibility, but the results of these previous studies have been contradictory. The objective of current study is to explore whether COL3A1 rs1800255 polymorphism confers risk to POP. Methods Relevant literatures were searched by searching databases including Pubmed, Embase, Google academic, the Cochrane library, China National Knowledge Infrastructure (CNKI). Search time is from database foundation to March 2021. Results A total of seven literatures were enrolled in the present meta-analysis, including 1642 participants. Overall, no significant association was found by any genetic models. In subgroup analysis based on ethnicity, significant associations were demonstrated in Caucasians by allele contrast (A vs. G: OR = 1.34, 95%CI = 1.03–1.74,), homozygote comparison (AA vs. GG: OR = 3.25, 95%CI = 1.39–7.59), and recessive genetic model (AA vs. GG/GA: OR = 3.22, 95%CI = 1.40–7.42). Conclusions The present meta-analysis suggests that the COL3A1 is a candidate gene for POP susceptibility. Caucasian individuals with A allele and AA genotype have a higher risk of POP. The COL3A1 rs1800255 polymorphism may be risk factor for POP in Caucasian population.

show abstract

“…The risk of POP increases with age, reaching a peak in individuals aged 60–69 years ( 3 ). A sample study previously revealed that women in the 60–70 years age group experience higher levels of distress from POP compared with those in younger women regardless of the stage of prolapse ( 4 ). Pelvic organs are connected and are supported by the levator ani muscle complex, cardinal and uterosacral ligament (USL), endopelvic fascia and the pelvis itself ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)

et al. 2020

View full text Add to dashboard Cite

Pelvic organ prolapse (PoP) is a common symptom of pelvic floor disorders which is characterized by the descent of the uterus, bladder or bowel from their normal anatomical position towards or through the vagina. Among the older population, the incidence of POP increases with age. It is becoming necessary to recognize that POP is a degenerative disease that is correlated with age. In recent years, studies have been performed to improve understanding of the cellular and molecular mechanisms concerning senescent fibroblasts in pelvic tissues, which contribute to the loss of structure supporting the pelvic organs. These mechanisms can be classified into gene and mitochondrial dysfunctions, intrinsic senescence processes, protein imbalance and alterations in stem cells. The present review provides an integrated overview of the current research and concepts regarding POP, in addition to discussing how fibroblasts can be targeted to evade the negative impact of senescence on POP. However, it is probable that other mechanisms that can also cause POP exist during cell senescence, which necessitates further research and provides new directions in the development of novel medical treatment, stem cell therapy and non-surgical interventions for POP.

show abstract

The relationship between age and pelvic organ prolapse bother

Abstract: Women in the 6th and 7th decades of life experience higher levels of bother from POP than older or younger women with the same stage of prolapse. This suggests that women in these decades of life might be at a higher risk for impairment of quality of life from POP.

Cited by 26 publications

References 13 publications

Klotho Protein Reduced the Expression of Matrix Metalloproteinase-1 (MMP-1) and Matrix Metalloproteinase-3 (MMP-3) in Fibroblasts from Patients with Pelvic Organ Prolapse (POP) by Down-Regulating the Phosphorylation of ERK1/2

Klotho Protein Reduced the Expression of Matrix Metalloproteinase-1 (MMP-1) and Matrix Metalloproteinase-3 (MMP-3) in Fibroblasts from Patients with Pelvic Organ Prolapse (POP) by Down-Regulating the Phosphorylation of ERK1/2

COL3A1 rs1800255 polymorphism is associated with pelvic organ prolapse susceptibility in Caucasian individuals: Evidence from a meta-analysis

Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)

Contact Info

Product

Resources

About