The Relationship between Anemia and Helicobacter Pylori Infection in Children

Lupu, Ancuța; Miron, Ingrith; Cianga, Anca Lavinia; Cernomaz, Andrei Tudor; Lupu, Vasile Valeriu; Munteanu, Dragos Stefan; Ghica, Dragos Catalin; Fotea, Silvia

doi:10.3390/children9091324

Cited by 18 publications

(11 citation statements)

References 38 publications

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“…Prevention is one of the first steps that must be taken when dealing with a resistant moderate to severe iron deficiency anaemia, particularly when combined with gastrointestinal symptoms, even though the precise nature of their association is still unclear. 13 According to another study patients with unexplained or refractory iron deficiency anaemia had a higher prevalence of H. pylori infection (61.5%). Only the H. pylori infection and mean corpuscular volume were significantly correlated among the several hematological parameters examined (p-value 0.046).…”

Section: Discussionmentioning

confidence: 95%

Frequency of Anemia and Iron Deficiency Anemia in Patients with Helicobacter Pylori Infection: A Cross-Sectional Study

Nohario¹,

Siyal²,

Memon³

et al. 2023

PJMHS

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Objective: To determine the frequency of anemia and iron deficiency anemia in patients with Helicobacter pylori infection. Study design: Cross-sectional study Place and Duration: Department of Medicine, Liaquat University Hospital, Hyderabad from May to November 2019 Methodology: We included a total of 140 patients with anemia, either inpatients or outpatients at Liaquat University Hospital in Hyderabad's department of medicine. We acquired demographic information, such as name, gender, and age. The study involved everyone who meets the inclusion requirement. Anemia's brief history, its duration, the colour of the stools (melena black faeces), and the ferritin level were all noted. The cubital vein of either upper arm was used to collect 10 ml of blood, which was then sent to the lab for analysis of anaemia, ID, and H. Pylori detection. A multiparameter cell counter Sysmex k 1000 hematology analyzer was used to determine the amounts of haemoglobin (Hb) and hematocrit (Hct) in the CBC (Tao electronics, Japan). Serum iron levels were evaluated using a Hitachi 917 biochemistry automated analyzer, and ferritin concentrations were determined using a Cobas e411 hormones auto-analyzer from Roche Diagnostics GmbH in Mannheim, Germany (Roche Diagnostics GmbH, Mannheim, Germany). The researcher himself entered all the data on a proforma that had been previously created. Results: Patients' average ages ranged from 40.44± 14.268 years, and their haemoglobin levels were 8.77 ± 3.14. Patients' serum ferritin levels were 10.5 ±63.21 and their BMI was 24.5 ±3.21 respectively. Of the H. pylori patients, there were 70 (50%) anaemic patients and 70 (50%) with normal Hb levels. In this study, 102 individuals (72.9%) had normal serum profiles while 38 patients (27.1%) had iron deficiency anemia. Conclusion: According to our research, treating H. pylori infection may help IDA patients who are infected with the parasite especially those who have moderate to severe anaemia. Individuals with H. pylori infection had a significant prevalence of anaemia and IDA, and both conditions were linked to patients' ages and several behavioural traits Keywords: H. pylori infection, anemia, iron deficiency anemia

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Section: Discussionmentioning

confidence: 95%

Frequency of Anemia and Iron Deficiency Anemia in Patients with Helicobacter Pylori Infection: A Cross-Sectional Study

Nohario¹,

Siyal²,

Memon³

et al. 2023

PJMHS

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“…The severity of this case with altered mental status and cardiac failure on admission to ICU should be noted. Patient’s altered mental status could be caused by possible cerebral edema [ 24 ], edema that can be explained by tissue hypoxia due to severe anemia [ 25 ] and also by the low level of albumin [ 26 , 27 ]. Clinical research shows that hypoalbuminemia is frequently determined in case of critical patient with systemic inflammatory syndrome [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Esophageal ulcer associated with mild hemophilia A: case report

Nicolescu¹,

Neşiu²,

Uzum³

et al. 2022

Rom J Morphol Embryol

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In this paper, we present the case of a 68-year-old male with personal medical history of coagulopathy issues, who presented to our Emergency Room (Emergency County Hospital, Arad, Romania) with bleeding of the superior tract of the digestive system; the case was difficult to manage, thus warranting the intervention of the Department of Gastroenterology. Endoscopy was performed to localize the site of bleeding and to stop the hemorrhage. This procedure was not successful. The patient was transferred to our Intensive Care Unit where different medications, such as proton pump inhibitor, hemostatic agent and prokinetic drugs were administered. Unfortunately, our attempt to stop bleeding failed; this led us to expand our investigation. We focused on a possible hemophilia as the cause of bleeding, which was confirmed as hemophilia A through the coagulometry test after a period of three days. Patient medical history and coagulation test led us to believe that this is a very rare case of a mild hemophilia A. Finally, the correction of Factor VIII deficiency and repeated endoscopic hemostasis clip was able to stop patients bleeding and ensured a favorable clinical evolution of the patient.

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“…We excluded children who previously received eradication treatment of H. pylori , those who previously had treatment with acetaminophen or antibiotics, children with evidence of bleeding of the gastro-intestinal tract at endoscopy, those who complained of headache or migraine during previous hospitalizations or had a medical past history of headache/migraine, patients with gastrointestinal disorders known to be associated with headache such as inflammatory bowel syndrome, celiac disease, or functional abdominal pain, and patients with a history of drug use, including H2 blockers, antibiotics, or proton pump inhibitors, within 4 weeks [ 27 , 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Helicobacter pylori Infection in Children: A Possible Reason for Headache?

et al. 2023

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(1) Background: The correlation between infection with Helicobacter pylori (H. pylori) and headache has been argued and explored for a long time, but a clear association between the simultaneous presence of the two in children has not been established yet. In this study, we aimed to explore this relationship in children from the Northeast region of Romania. (2) Methods: A retrospective study exploring the correlation between children having H. pylori infection and headache or migraine was conducted on a batch of 1757 children, hospitalized over 3 years in a pediatric gastroenterology department in Northeast Romania. (3) Results: A total of 130 children of both sexes had headache. From 130 children, 54 children (41.5%) also presented H. pylori infection. A significant association between headache and H. pylori infection (χ2; p < 0.01) was noticed. (4) Conclusions: More studies are needed on this relationship, and we emphasize the importance of further analyses, as they present great clinical importance for both prompt diagnosis and treatment.

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The Relationship between Anemia and Helicobacter Pylori Infection in Children

Cited by 18 publications

References 38 publications

Frequency of Anemia and Iron Deficiency Anemia in Patients with Helicobacter Pylori Infection: A Cross-Sectional Study

Frequency of Anemia and Iron Deficiency Anemia in Patients with Helicobacter Pylori Infection: A Cross-Sectional Study

Esophageal ulcer associated with mild hemophilia A: case report

Helicobacter pylori Infection in Children: A Possible Reason for Headache?

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