The relationship between axonal spike shape and functional modality in cutaneous C-fibres in the pig and rat

Gee, Michelle; Lynn, Bruce; Basile, S; Pierau, Fr.-K.; Cotsell, B.

doi:10.1016/s0306-4522(98)00454-0

Cited by 26 publications

(23 citation statements)

References 29 publications

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“…2 and Table 1, for most subgroups of C-fibre neurones the distributions and medians of CV were similar, as previously reported (Gee et al 1999). However, in contrast to that study (Gee et al 1999) and to a study in the guinea-pig (Djouhri et al 1998), the C-fibre cooling units tended to have a faster median CV than the other subgroups (except C MC units) with a significantly faster median CV than the C HTM units ( Fig. 2 and Table 1).…”

Section: Conduction Velocitysupporting

confidence: 85%

“…An inverse relationship between somatic AP duration and CV has been reported in several species (Harper & Lawson, 1985;Cameron et al 1986;Rose et al 1986;Ritter & Mendell, 1992;Gee et al 1999) for all types of DRG neurone grouped together. Here we show such plots for nociceptive and LTM units separately (Fig.…”

Section: Action Potential Duration Rise Time and Fall Timementioning

confidence: 83%

“…Nociceptive DRG neuronal somata tend to have broader APs than low-threshold mechanoreceptive (LTM) units in the same CV group. This was demonstrated for A-fibre neurones in cat (Koerber et al 1988), rat (Ritter & Mendell, 1992) and guinea-pig (Djouhri et al 1998), for C-fibre neurones in guinea-pig (Djouhri et al 1998), and for afferent C-fibres in pig and rat (Gee et al 1999). In contrast, in cat DRGs, both C-nociceptive and C-LTM neurones were reported to have broad somatic APs (Traub & Mendell, 1988).…”

mentioning

confidence: 94%

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Electrophysiological differences between nociceptive and non‐nociceptive dorsal root ganglion neurones in the rat in vivo

Fang

McMullan

Lawson

et al. 2005

The Journal of Physiology

200

208

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Section: Conduction Velocitysupporting

confidence: 85%

Section: Action Potential Duration Rise Time and Fall Timementioning

confidence: 83%

mentioning

confidence: 94%

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Electrophysiological differences between nociceptive and non‐nociceptive dorsal root ganglion neurones in the rat in vivo

Fang

McMullan

Lawson

et al. 2005

The Journal of Physiology

200

208

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“…As described previously (Obreja et al, 2010), saphenous nerves were exposed at mid-thigh over a length of about 6 cm and the teased fiber technique (Campbell and Meyer, 1983;Gee et al, 1999) was used to extracellularly record action potentials from single nerve fibers. Signals were amplified (Model 5113, Ametek Inc., TN, USA), audio monitored, filtered (Model 3364, Krohn-Hite Corporation, Brockton, MA, USA) and displayed on an oscilloscope.…”

Section: Extracellular Single Fiber Recordingsmentioning

confidence: 99%

TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors

Jonas

Prato

Lechner

et al. 2020

Front. Cell. Neurosci.

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Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, "silent" nociceptors and might be due to high expression of Na V 1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX-r). Nociceptor-class specific differences in action potential characteristics were studied by: (i) in vitro calcium imaging in single porcine nerve growth factor (NGF)-responsive neurites; (ii) in vivo extracellular recordings in functionally identified porcine silent nociceptors; and (iii) in vitro patch-clamp recordings from murine silent nociceptors, genetically defined by nicotinic acetylcholine receptor subunit alpha-3 (CHRNA3) expression. Porcine TTX-r neurites (n = 26) in vitro had more than twice as high calcium transients per action potential as compared to TTX-s neurites (n = 18). In pig skin, silent nociceptors (n = 14) characterized by pronounced activity-dependent slowing of conduction were found to be TTX-r, whereas polymodal nociceptors were TTX-s (n = 12) and had only moderate slowing. Mechano-insensitive cold nociceptors were also TTX-r but showed less activity-dependent slowing than polymodal nociceptors. Action potentials in murine silent nociceptors differed from putative polymodal nociceptors by longer duration and higher peak amplitudes. Longer duration AP in silent murine nociceptors linked to increased sodium load would be compatible with a pronounced activity-dependent slowing in pig silent nociceptors and longer AP durations could be in line with increased calcium transients per action potential observed in vitro in TTX-resistant NGF responsive porcine neurites. Even though there is no direct link between slowing and TTX-resistant channels, the results indicate that axons of silent nociceptors not only differ in their receptive but also in their axonal properties.

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“…Although it has been suggested that differences in AP shape correlates with conduction velocity, evidence suggests a more important correlation with sensory function. Across fiber types, the differences in AP shape correlate less with fiber type than with functional differences such as between different functional classes of Cfiber neurons (Gee et al 1999) or between nociceptors and mechanoreceptors or between subtypes of mechanoreceptors (Djouhri et al 1998).…”

Section: Functional Relationships Associated With Tonic and Phasic Fimentioning

confidence: 99%

Morphological and functional diversity of first-order somatosensory neurons

2017

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First-order somatosensory neurons transduce and convey information about the external or internal environment of the body to the central nervous system. They are pseudo unipolar neurons with cell bodies residing in one of several ganglia located near the central nervous system, with the short branch of the axon connecting to the spinal cord or the brain stem and the long branch extending towards the peripheral organ they innervate. Besides their sensory transducer and conductive role, somatosensory neurons also have trophic functions in the tissue they innervate and participate in local reflexes in the periphery. The cell bodies of these neurons are remarkably diverse in terms of size, molecular constitution, and electrophysiological properties. These parameters have provided criteria for classification that have proved useful to establish and study their functions. In this review, we discuss ways to measure and classify populations of neurons based on their size and action potential firing pattern. We also discuss attempts to relate the different populations to specific sensory modalities.

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The relationship between axonal spike shape and functional modality in cutaneous C-fibres in the pig and rat

Cited by 26 publications

References 29 publications

Electrophysiological differences between nociceptive and non‐nociceptive dorsal root ganglion neurones in the rat in vivo

Electrophysiological differences between nociceptive and non‐nociceptive dorsal root ganglion neurones in the rat in vivo

TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors

Morphological and functional diversity of first-order somatosensory neurons

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