The relationship between B vitamin supplementation and pruritus incidence in adults a systematic review and meta-analysis

Abstract

We aim to assess the prevalence of pruritus or itching in adult patients taking Vitamin B supplementation. The method applied in this paper is a systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to 30th October 2023. All statistical analyses were conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result was reported in prevalence and their corresponding 95% confidence interval (CI). Five studies (three randomized controlled trials and two observational studies) were included in our analysis. We analyzed the prevalence of vitamin B3 (niacin) and B12 (cyanocobalamin). There was a statistically significant prevalence of pruritis in participants treated with niacin (