The Relationship Between Blood Monocyte Count and Coronary Artery Ectasia

Abstract

BackgroundThe pathophysiology of coronary artery ectasia (CAE) has not been clearly identified, although multiple abnormalities including arteritis, endothelial dysfunction, and atherothrombosis have been reported. It is known that monocytes play an important role in inflammation, atherosclerosis and cardiovascular disease. We aimed to compare the numbers of monocyte counts of the CAE patients versus controls.MethodThis study included 84 CAE patients (40 male, mean age 55.4 ± 9.7 years) and 30 controls (10 male, mean age 57.86 ± 11.6 years). Concurrent routine biochemical tests and neutrophil, lymphocyte, monocyte count and mean platelet volume (MPV) on whole blood count were performed for these participants. These parameters were compared between groups.ResultsBaseline characteristics of the study groups were comparable. CAE patients had a higher MPV value and monocyte count than controls (8.8 ± 0.2 vs. 6.2 ± 1.6 fL and 732 ± 88 vs. 321 ± 75 cell/μL; both P < 0.001, respectively).ConclusionAs a result, our study revealed a relationship between monocyte count and MPV in patients with CAE.

Comparison of mean platelet volume levels in coronary artery ectasia and healthy people: systematic review and meta-analysis

“…A total of 14 articles met the inclusion and quality control criteria for this study, all of which were published from studies performed in Turkey from 2007 to 2016 (Fig. 1) [1112151617181920212223242526]. A total of 2,323 people were evaluated in the mentioned studies, including 957 healthy individuals [465 females (F) and 492 males (M)] with mean ages of 55±5.25 (for F) and 37±5.25 (for M) years and 1,366 patients [610 females (F) and 748 males (M)] with mean ages for females of 58±4.3 years and 58±4.3 years for males (Table 1).…”

“…Among the 14 studies investigated, the studies by Sen et al (2007) (95% CI, −1.138 to −0.399) and Demir et al (2014) (95% CI, 2.54 to 3.708) showed the lowest and highest values of MPV SMD of −0.769 and 3.124, respectively [2021]. After pooling the results of all articles, a total SMD value of 0.584 (95% CI, 0.219, 0.95) was obtained using the D+L pooled SMD, indicating a significant difference ( P =0.002) between the two groups and higher MPV values in the ectatic patient group in comparison with healthy individuals (Table 2).…”

The relationship between radial artery spasm and adropin levels in patients undergoing transradial coronary angiography

“… 19 , 20 Additionally, increased monocyte count seems to be associated with deterioration in the vascular structure. 21 MHR is also an important inflammatory marker, and it is associated with major cardiovascular adverse events in patients with CAD. 22 , 23 MHR seems to be associated with increased oxidative stress and inflammatory status in patients with CAD, and is a predictor of severe and complex coronary atherosclerosis.…”