The Relationship Between Blood Pressure Variability and Cardiovascular Remodeling in Hypertension Developed in the Elderly

Кастанаян, А. А.; Железняк, Е. И.; Хагуш, А. К.; Демидова, А. А.; Kartashova, Elena; Жулитов, А. Ю.

doi:10.18705/1607-419x-2016-22-4-389-400

Cited by 4 publications

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“…Имеется множество данных о взаимосвязи повышенной вариабельности АД в течение суток с ПОМ [4,7,8,10,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. В частности известно, что повышенная вариабельность АД в течение суток, в период сна и бодрствования взаимосвязана с ГЛЖ [27][28][29][30][31][32], а также с глобальным продольным систолическим 2D-стрейном левого желудочка (ГПС ЛЖ) [33][34][35], параметром, характеризующим деформационные и упруго-эластические свойства ЛЖ. Следует отметить, что на сегодняшний день [10,44,45].…”

Section: Discussionunclassified

“…Доза бисопролола титруется до достижения ЧСС 58-60 в 1 мин. Стабилизация состояния больного и оптимальный уровень артериального давления (АД) позволяет с осторожностью присоединять И-АПФ [31].…”

Section: прогноз и лечение кардиотоксчностиunclassified

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2018

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Дисфункциональные типы кровообращения у практически здоровых молодых людей: особенности функционального состояния сосудов и центральной гемодинамики Хурса Р.В. Применение розувастатина у больных хронической обструктивной болезнью легких.

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Section: Discussionunclassified

Section: прогноз и лечение кардиотоксчностиunclassified

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2018

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Single Pill Indapamide and Perindopril Arginine Combination: Optimal Coupling of Vascular Protection and Hemodynamic Risk Factors Reduction in Patients with Essential Arterial Hypertension

2019

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Objective: to investigate the impact of indapamide / perindopril single-pill combination (I / P SPC) on arterial stiffness parameters, blood pressure (BP) level and BP variability (BPV) in middle-aged patients with stage II grade 1–2 essential arterial hypertension (EAH). Materials and methods. We retrospectively formed a group of patients with stage II grade 1–2 EAH who had not previously received regular antihypertensive therapy (AHT) (n=52, mean age 52.9±6.0 years). All patients were treated with I / P SPC and all of them achieved target office BP level (less than 140 / 90 mm Hg). After 12 weeks of follow-up (from the time of reaching the target BP) assessment of AHT effectiveness (general clinical data, ambulatory blood pressure monitoring [ABPM], volume sphygmography, echocardiography), and vascular stiffness evaluation were performed.Results. At the end of follow-up office systolic BP (SBP), diastolic BP (DBP), pulse BP, day-time, night-time and 24‑hour SBP and DBP significantly (p<0.001 for all) decreased. According to the ABPM data day-time, nighttime, and 24‑hour systolic BPV significantly decreased (p=0.029, p=0.006 and p<0.001, respectively); day-time and 24‑hour diastolic BPV also significantly decreased (p=0.001 and p<0.001, respectively). Day-night standard deviation (SDdn) significantly decreased too (p=0.002 and p<0.001, respectively). Volumetric sphygmography showed significant decrease of right cardio-ankle vascular index (CAVI) (from 8.20±1.29 to 7.58±1.44, p=0.001) and of left CAVI (from 8.13±1.40 to 7.46±1.43, p<0.001), as well as reduction of the number o f patients with a right- and / or left-CAVI >9.0 (from 32.7 to 11.5 %, p=0.018). According to assessment of arterial stiffness using the Vasotens24 software package, the arterial stiffness index (ASI) significantly (p<0.001) decreased from 153.5±29.9 to 138.3±20.0 (by –9.2±13.1 %). Transthoracic echocardiography data demonstrated significant decrease (p<0.001) in effective arterial elastance (from 1.82±0.43 to 1.58±0.36 mm Hg; by –11.85±16.29 %) and significant (p<0.001) increase in the arterial compliance – from 1.27±0.34 to 1.54±0.38 mm Hg / ml (+26.95±38.06 %).Conclusion. In AHT naive patients 40–65 years old with stage II grade 1–2 EAH therapy with I / P SPC provided effective 24‑hour BP control, reduced BPV and improved arterial stiffness parameters.

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Disadaptive reactions of the cardiovascular system in relation to sleep and coping behavior in students of northern medical institute

2019

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The aim of the study is to assess the relation between hemodynamic parameters and coping behavior and sleep in order to maintain health of students of the northern university. Design and methods. We examined 96 students of the northern medical university (61 females). During academic days, we performed ambulatory monitoring of blood pressure (ABPM) 24 h + 10–120 minutes. We analyzed following parameters: mezors of heart rate (HR), systolic (SBP), diastolic (DBP), and pulse blood pressure (BP), mean BP, Kerdo autonomic index (KI), functional change index (FCI); hypertension time indices of SBP (TI SBP) and DBD (TI DBP) (%), variability of SBP (Var. SBD) and DBD (Var. DBP); night dipping of SBP and DBP (%). We assessed coping behavior. The sleep was assessed using the subjective characteristics of sleep questionnaire and the Epworth sleepiness scale. Statistical analysis was performed using Statistica 10.0 and Excel 2013 software. Results. We found optimal/normal values of mean BP and intersexual differences among students. Female students in all periods showed higher rates of HR and sympathetic influences; males had higher SBD, higher TI SBP during day and night, higher SBP variability at night, and tended to develop isolated systolic hypertension. Parameters and dynamics of the vascular component of BP are in normal ranges. We did not find significant intersexual differences in mechanisms of the vascular regulation. Cardiovascular system regulation in males depended on the sleep and coping, and it was more autonomous from behavior in girls. Conclusions. One of the most effective and affordable ways to prevent cardiovascular diseases during the university education is the consistent training of students in adaptive behavior in a situation of psycho-emotional stress and recommendations on sleep hygiene. Greater efficiency of the learning adaptive coping behavior can be expected in males, and male gender is one of the non-modifiable risk factors for cardiovascular pathology.

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The Relationship Between Blood Pressure Variability and Cardiovascular Remodeling in Hypertension Developed in the Elderly

Cited by 4 publications

References 0 publications

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Single Pill Indapamide and Perindopril Arginine Combination: Optimal Coupling of Vascular Protection and Hemodynamic Risk Factors Reduction in Patients with Essential Arterial Hypertension

Disadaptive reactions of the cardiovascular system in relation to sleep and coping behavior in students of northern medical institute

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